The mystery of massive mitochondrial complexes: the apicomplexan respiratory chain.
Apicomplexa
F(o)-F(1) ATP synthase
Plasmodium
Toxoplasma
mitochondrial electron transport chain
mitochondrion
Journal
Trends in parasitology
ISSN: 1471-5007
Titre abrégé: Trends Parasitol
Pays: England
ID NLM: 100966034
Informations de publication
Date de publication:
12 2022
12 2022
Historique:
received:
06
07
2022
revised:
21
09
2022
accepted:
23
09
2022
pubmed:
28
10
2022
medline:
15
11
2022
entrez:
27
10
2022
Statut:
ppublish
Résumé
The mitochondrial respiratory chain is an essential pathway in most studied eukaryotes due to its roles in respiration and other pathways that depend on mitochondrial membrane potential. Apicomplexans are unicellular eukaryotes whose members have an impact on global health. The respiratory chain is a drug target for some members of this group, notably the malaria-causing Plasmodium spp. This has motivated studies of the respiratory chain in apicomplexan parasites, primarily Toxoplasma gondii and Plasmodium spp. for which experimental tools are most advanced. Studies of the respiratory complexes in these organisms revealed numerous novel features, including expansion of complex size. The divergence of apicomplexan mitochondria from commonly studied models highlights the diversity of mitochondrial form and function across eukaryotic life.
Identifiants
pubmed: 36302692
pii: S1471-4922(22)00219-7
doi: 10.1016/j.pt.2022.09.008
pmc: PMC10434753
mid: NIHMS1921970
pii:
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1041-1052Subventions
Organisme : NIAID NIH HHS
ID : R00 AI137218
Pays : United States
Organisme : Wellcome Trust
ID : 221681/Z/20/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/W002221/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 217173/Z/19/Z
Pays : United Kingdom
Informations de copyright
Copyright © 2022 The Authors. Published by Elsevier Ltd.. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests No interests are declared.
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