Lacticaseibacillus rhamnosus Probio-M9 extends the lifespan of Caenorhabditis elegans.
Journal
Communications biology
ISSN: 2399-3642
Titre abrégé: Commun Biol
Pays: England
ID NLM: 101719179
Informations de publication
Date de publication:
27 10 2022
27 10 2022
Historique:
received:
22
02
2022
accepted:
23
09
2022
entrez:
27
10
2022
pubmed:
28
10
2022
medline:
1
11
2022
Statut:
epublish
Résumé
Probiotics have been characterized as useful for maintaining the balance of host gut flora and conferring health effects, but few studies have focused on their potential for delaying aging in the host. Here we show that Lacticaseibacillus rhamnosus Probio-M9 (Probio-M9), a healthy breast milk probiotic, enhances the locomotor ability and slows the decline in muscle function of the model organism Caenorhabditis elegans. Live Probio-M9 significantly extends the lifespan of C. elegans in a dietary restriction-independent manner. By screening various aging-related mutants of C. elegans, we find that Probio-M9 extends lifespan via p38 cascade and daf-2 signaling pathways, independent on daf-16 but dependent on skn-1. Probio-M9 protects and repairs damaged mitochondria by activating mitochondrial unfolded protein response. The significant increase of amino acids, sphingolipid, galactose and fatty acids in bacterial metabolites might be involved in extending the lifespan of C. elegans. We reveal that Probio-M9 as a dietary supplementation had the potential to delay aging in C. elegans and also provide new methods and insights for further analyzing probiotics in improving host health and delaying the occurrence of age-related chronic diseases.
Identifiants
pubmed: 36302976
doi: 10.1038/s42003-022-04031-2
pii: 10.1038/s42003-022-04031-2
pmc: PMC9613993
doi:
Substances chimiques
Caenorhabditis elegans Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1139Informations de copyright
© 2022. The Author(s).
Références
Mech Ageing Dev. 2006 May;127(5):473-80
pubmed: 16499950
Cell Metab. 2010 Jun 9;11(6):453-65
pubmed: 20519118
Proc Natl Acad Sci U S A. 2020 Jul 21;117(29):17142-17150
pubmed: 32636256
Cell. 2018 Aug 9;174(4):870-883.e17
pubmed: 30057120
Nat Commun. 2017 Jan 30;8:14332
pubmed: 28134244
Biomed Res Int. 2018 May 8;2018:9478630
pubmed: 29854813
Nature. 2010 Mar 25;464(7288):504-12
pubmed: 20336132
Annu Rev Genomics Hum Genet. 2001;2:435-62
pubmed: 11701657
Nature. 2005 Nov 10;438(7065):179-84
pubmed: 16281027
Nat Rev Immunol. 2010 Jan;10(1):47-58
pubmed: 20029447
Mol Cells. 2009 Sep;28(3):209-13
pubmed: 19756391
Biogerontology. 2013 Feb;14(1):73-87
pubmed: 23291976
Cell. 2014 Jan 30;156(3):408-11
pubmed: 24485451
Biomed Res Int. 2017;2017:5939818
pubmed: 29109959
Biosci Biotechnol Biochem. 2011;75(9):1746-51
pubmed: 21897025
BMB Rep. 2016 Feb;49(2):81-92
pubmed: 26698870
Biochim Biophys Acta. 2013 Feb;1833(2):410-6
pubmed: 22445420
Mech Ageing Dev. 1977 Nov-Dec;6(6):413-29
pubmed: 926867
Mech Ageing Dev. 2014 Nov-Dec;141-142:22-5
pubmed: 25263107
Front Genet. 2017 Sep 21;8:132
pubmed: 28983319
Front Cell Infect Microbiol. 2022 Jan 19;11:819328
pubmed: 35127565
Ageing Res Rev. 2011 Jul;10(3):319-29
pubmed: 21145432
BMC Res Notes. 2019 May 14;12(1):269
pubmed: 31088517
Cell Rep. 2020 Jan 14;30(2):367-380.e7
pubmed: 31940482
Adv Exp Med Biol. 2012;710:19-27
pubmed: 22127882
Appl Environ Microbiol. 2007 Oct;73(20):6404-9
pubmed: 17704266
PLoS Genet. 2010 Apr 01;6(4):e1000892
pubmed: 20369020
Int J Med Microbiol. 2010 Jan;300(1):57-62
pubmed: 19783474
BMC Dev Biol. 2008 Mar 12;8:28
pubmed: 18366811
Sci Rep. 2015 Nov 25;5:17128
pubmed: 26601690
Nature. 1998 Nov 12;396(6707):133-40
pubmed: 9823893
Nature. 2013 May 23;497(7450):451-7
pubmed: 23698443
J Dairy Sci. 2014 Nov;97(11):6828-34
pubmed: 25200770
Nat Immunol. 2004 May;5(5):488-94
pubmed: 15048112
Mech Ageing Dev. 2011 Apr;132(4):210-2
pubmed: 21354440
Nat Cell Biol. 2015 Mar;17(3):196-203
pubmed: 25720959
Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6593-8
pubmed: 15123841
Nat Rev Immunol. 2013 Sep;13(9):679-92
pubmed: 23954936
Sci Rep. 2017 Aug 7;7(1):7408
pubmed: 28785042
Nature. 1993 Dec 2;366(6454):461-4
pubmed: 8247153
BMC Genet. 2015 Feb 03;16:8
pubmed: 25643626
Genetics. 1974 May;77(1):95-104
pubmed: 4858229
Genetics. 2002 Jul;161(3):1101-12
pubmed: 12136014
Cell. 2011 Jan 7;144(1):79-91
pubmed: 21215371
Cell. 2013 Feb 14;152(4):818-30
pubmed: 23415229
Free Radic Biol Med. 2015 Nov;88(Pt B):290-301
pubmed: 26232625
Metab Brain Dis. 2016 Apr;31(2):337-45
pubmed: 26518192
Science. 2002 Dec 20;298(5602):2398-401
pubmed: 12471266
Nutrients. 2021 Mar 30;13(4):
pubmed: 33808480
Exp Gerontol. 1980;15(4):285-9
pubmed: 7409025
Dev Dyn. 2010 May;239(5):1306-14
pubmed: 20151474
Gut Microbes. 2020 Nov 9;12(1):1736974
pubmed: 32200683
Microbiome. 2018 Mar 21;6(1):54
pubmed: 29562943
Sci Rep. 2018 May 10;8(1):7441
pubmed: 29748542
Aging Cell. 2016 Apr;15(2):227-36
pubmed: 26710940
Front Microbiol. 2017 Jun 28;8:1206
pubmed: 28702021
Genetics. 1974 May;77(1):71-94
pubmed: 4366476
Infect Immun. 2012 Jul;80(7):2500-8
pubmed: 22585961
Science. 2002 Jul 26;297(5581):623-6
pubmed: 12142542
Cold Spring Harb Perspect Biol. 2012 Mar 01;4(3):
pubmed: 22296764
PLoS One. 2013 Jul 19;8(7):e70087
pubmed: 23894595
J Dairy Sci. 2020 May;103(5):4013-4025
pubmed: 32113772
Int J Food Microbiol. 2011 Aug 2;148(2):80-6
pubmed: 21652104
Neurobiol Stress. 2021 Jan 12;14:100294
pubmed: 33511258
Mol Cell. 2015 Apr 2;58(1):123-33
pubmed: 25773600
PLoS One. 2012;7(12):e52493
pubmed: 23300685
Cell. 2020 Mar 5;180(5):984-1001.e22
pubmed: 32109414
Cell. 2005 Feb 25;120(4):483-95
pubmed: 15734681
PLoS One. 2013 Nov 07;8(11):e79319
pubmed: 24244480
Nature. 2007 May 31;447(7144):545-9
pubmed: 17538612
Nephrol Dial Transplant. 2002 Mar;17(3):528-9
pubmed: 11865115
BMC Biol. 2012 Jul 31;10:66
pubmed: 22849295
Cell. 2019 Sep 5;178(6):1299-1312.e29
pubmed: 31474368
Science. 2012 Aug 3;337(6094):587-90
pubmed: 22700657
Science. 1997 Aug 15;277(5328):942-6
pubmed: 9252323
Science. 2003 May 16;300(5622):1142-5
pubmed: 12750521
Cell. 2017 Jun 15;169(7):1249-1262.e13
pubmed: 28622510
Gut Microbes. 2020 Jul 3;11(4):930-943
pubmed: 32079472
Curr Opin Biotechnol. 2012 Apr;23(2):192-201
pubmed: 22137452
Dev Cell. 2001 Nov;1(5):633-44
pubmed: 11709184
Cell. 2008 Mar 21;132(6):1025-38
pubmed: 18358814
Nat Rev Gastroenterol Hepatol. 2014 Aug;11(8):506-14
pubmed: 24912386
FASEB J. 2005 May;19(7):860-2
pubmed: 15728664
J Nutr Health Aging. 2012 Apr;16(4):402-10
pubmed: 22499466
Methods. 2014 Aug 1;68(3):476-86
pubmed: 24727065
PLoS One. 2015 Jul 29;10(7):e0134401
pubmed: 26222828
PLoS Pathog. 2011 Dec;7(12):e1002453
pubmed: 22216003
Nutrients. 2018 Dec 05;10(12):
pubmed: 30563064
Immunology. 2007 Apr;120(4):435-46
pubmed: 17313487
Free Radic Biol Med. 2003 Jun 1;34(11):1405-15
pubmed: 12757851
Aging Cell. 2006 Apr;5(2):97-108
pubmed: 16626389