Disruption of white matter integrity and its relationship with cognitive function in non-severe traumatic brain injury.
diffusion MRI
fractional anisotropy
neuropsychological test
tract-based spatial statistic
traumatic brain injury
Journal
Frontiers in neurology
ISSN: 1664-2295
Titre abrégé: Front Neurol
Pays: Switzerland
ID NLM: 101546899
Informations de publication
Date de publication:
2022
2022
Historique:
received:
04
08
2022
accepted:
23
09
2022
entrez:
28
10
2022
pubmed:
29
10
2022
medline:
29
10
2022
Statut:
epublish
Résumé
Impairment in cognitive function is a recognized outcome of traumatic brain injury (TBI). However, the degree of impairment has variable relationship with TBI severity and time post injury. The underlying pathology is often due to diffuse axonal injury that has been found even in mild TBI. In this study, we examine the state of white matter putative connectivity in patients with non-severe TBI in the subacute phase, i.e., within 10 weeks of injury and determine its relationship with neuropsychological scores. We conducted a case-control prospective study involving 11 male adult patients with non-severe TBI and an age-matched control group of 11 adult male volunteers. Diffusion MRI scanning and neuropsychological tests were administered within 10 weeks post injury. The difference in fractional anisotropy (FA) values between the patient and control groups was examined using tract-based spatial statistics. The FA values that were significantly different between patients and controls were then correlated with neuropsychological tests in the patient group. Several clusters with peak voxels of significant FA reductions ( The non-severe TBI patients had abnormally reduced FA values in multiple regions compared to controls that correlated with several measures of executive function during the sub-acute phase of TBI.
Sections du résumé
Background
UNASSIGNED
Impairment in cognitive function is a recognized outcome of traumatic brain injury (TBI). However, the degree of impairment has variable relationship with TBI severity and time post injury. The underlying pathology is often due to diffuse axonal injury that has been found even in mild TBI. In this study, we examine the state of white matter putative connectivity in patients with non-severe TBI in the subacute phase, i.e., within 10 weeks of injury and determine its relationship with neuropsychological scores.
Methods
UNASSIGNED
We conducted a case-control prospective study involving 11 male adult patients with non-severe TBI and an age-matched control group of 11 adult male volunteers. Diffusion MRI scanning and neuropsychological tests were administered within 10 weeks post injury. The difference in fractional anisotropy (FA) values between the patient and control groups was examined using tract-based spatial statistics. The FA values that were significantly different between patients and controls were then correlated with neuropsychological tests in the patient group.
Results
UNASSIGNED
Several clusters with peak voxels of significant FA reductions (
Conclusion
UNASSIGNED
The non-severe TBI patients had abnormally reduced FA values in multiple regions compared to controls that correlated with several measures of executive function during the sub-acute phase of TBI.
Identifiants
pubmed: 36303559
doi: 10.3389/fneur.2022.1011304
pmc: PMC9592834
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1011304Informations de copyright
Copyright © 2022 Abdullah, Ahmad, Zakaria, Tamam, Abd Hamid, Chai, Omar, Abdul Rahman, Fitzrol, Idris, Ghani, Wan Mohamad, Mustafar, Hanafi, Reza, Umar, Mohd Zulkifly, Ang, Zakaria, Musa, Othman, Embong, Sapiai, Kandasamy, Ibrahim, Abdullah, Amaruchkul, Valdes-Sosa, Bringas Vega, Biswal, Songsiri, Yaacob, Sumari, Noh, Azman, Jamir Singh and Abdullah.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Behav Neurosci. 2010 Jun;124(3):405-13
pubmed: 20528085
Medicine (Baltimore). 2019 Jul;98(30):e16360
pubmed: 31348236
Sci Rep. 2017 Feb 08;7:42327
pubmed: 28176877
Proc Natl Acad Sci U S A. 2018 Jan 16;115(3):595-600
pubmed: 29282320
Dev Neuropsychol. 2016 Apr;41(3):176-200
pubmed: 27232263
Hum Brain Mapp. 2002 Nov;17(3):143-55
pubmed: 12391568
Magn Reson Med. 2003 Nov;50(5):1077-88
pubmed: 14587019
PLoS One. 2016 Mar 11;11(3):e0151489
pubmed: 26967320
Epilepsy Behav. 2019 Dec;101(Pt A):106538
pubmed: 31678807
Geroscience. 2021 Aug;43(4):2015-2039
pubmed: 33900530
Cancer Imaging. 2010 Oct 04;10 Spec no A:S163-71
pubmed: 20880787
Neuropsychologia. 2017 Jul 28;102:95-108
pubmed: 28552783
Lancet Neurol. 2019 Oct;18(10):953-961
pubmed: 31451409
AJNR Am J Neuroradiol. 2004 May;25(5):738-45
pubmed: 15140712
Arch Phys Med Rehabil. 2017 Nov;98(11):2308-2319
pubmed: 28433414
Neuropsychol Rev. 2015 Sep;25(3):250-71
pubmed: 26255305
Philos Trans R Soc Lond B Biol Sci. 2005 May 29;360(1457):893-902
pubmed: 16087434
Arch Clin Neuropsychol. 2004 Aug;19(5):703-8
pubmed: 15330000
Front Psychol. 2020 Jul 07;11:1423
pubmed: 32733322
Sci Adv. 2020 Aug 07;6(32):eaaz6892
pubmed: 32821816
Neuroimage. 2017 Feb 1;146:1128-1141
pubmed: 27720819
Front Hum Neurosci. 2021 Jul 20;15:675376
pubmed: 34354575
J Neurotrauma. 2015 Nov 15;32(22):1693-721
pubmed: 26176603
Neuroimage. 2017 May 15;152:371-380
pubmed: 28284801
Front Psychol. 2021 Sep 29;12:691577
pubmed: 34659007
J Head Trauma Rehabil. 2010 Jul-Aug;25(4):241-55
pubmed: 20611043
Brain. 2020 Dec 1;143(12):3685-3698
pubmed: 33099608
Nat Neurosci. 2019 May;22(5):820-827
pubmed: 30962628
Brain Imaging Behav. 2018 Dec;12(6):1607-1621
pubmed: 29383621
Neurosurg Clin N Am. 2016 Oct;27(4):409-39
pubmed: 27637393
Neurosci Biobehav Rev. 2018 Sep;92:93-103
pubmed: 29803527
Radiographics. 2019 Oct;39(6):1571-1595
pubmed: 31589576
J Neurosci. 2017 Jul 5;37(27):6394-6407
pubmed: 28546311
Neuroimage. 2006 Jul 15;31(4):1487-505
pubmed: 16624579
Neuroimage. 2012 Aug 15;62(2):782-90
pubmed: 21979382
Clin Neuropsychol. 2022 Oct;36(7):1637-1652
pubmed: 33356888
J Neurotrauma. 2020 Jan 15;37(2):373-381
pubmed: 31595833
Brain. 2020 Apr 1;143(4):1158-1176
pubmed: 32243506
J Neurotrauma. 2013 Dec 1;30(23):1991-4
pubmed: 23822854
Neuroscientist. 2021 Feb;27(1):88-103
pubmed: 32723129
AJNR Am J Neuroradiol. 2012 Dec;33(11):2117-22
pubmed: 22723057
Brain. 2021 Feb 12;144(1):92-113
pubmed: 33257929
Concussion. 2017 Mar 22;2(2):CNC35
pubmed: 30202576
Exp Neurol. 2016 Jan;275 Pt 3:328-333
pubmed: 25697845
Brain. 2007 Oct;130(Pt 10):2508-19
pubmed: 17872928
Cortex. 2012 Feb;48(2):156-65
pubmed: 21813118
J Neurotrauma. 2021 Oct 1;38(19):2686-2697
pubmed: 33906419
BMC Neurol. 2011 Feb 23;11:24
pubmed: 21345223
Geroscience. 2020 Oct;42(5):1411-1429
pubmed: 32743786
Front Neural Circuits. 2019 May 07;13:28
pubmed: 31133818
Neuroimage Clin. 2015 Feb 12;7:493-505
pubmed: 25737958
J Neurotrauma. 2015 Dec 1;32(23):1834-48
pubmed: 25158206
Biol Psychiatry Cogn Neurosci Neuroimaging. 2021 Nov;6(11):1100-1109
pubmed: 33957321
EXCLI J. 2015 Jul 07;14:801-8
pubmed: 26600750
Neuropsychologia. 1971 Mar;9(1):97-113
pubmed: 5146491
Brain Inj. 2021 Feb 23;35(3):275-284
pubmed: 33507820
Brain Inj. 2008 Feb;22(2):115-22
pubmed: 18240040
NeuroRehabilitation. 2011;28(2):63-74
pubmed: 21447905
Int J Mol Sci. 2020 Apr 14;21(8):
pubmed: 32295258
Brain Imaging Behav. 2012 Jun;6(2):137-92
pubmed: 22438191
Neuroimage Clin. 2016 Nov 17;13:174-180
pubmed: 27981032
Neurobiol Dis. 2019 Mar;123:27-41
pubmed: 30059725
AJNR Am J Neuroradiol. 2013 Nov-Dec;34(11):2064-74
pubmed: 23306011
Front Cell Neurosci. 2019 Nov 27;13:528
pubmed: 31827423
NMR Biomed. 2002 Nov-Dec;15(7-8):435-55
pubmed: 12489094
Appl Neuropsychol Adult. 2020 May-Jun;27(3):219-231
pubmed: 30646771
Front Neurol. 2021 Mar 18;12:664445
pubmed: 33815264