Varicoceles in Men With Non-obstructive Azoospermia: The Dilemma to Operate or Not.
ICSI
non-obstructive azoospermia
spermatozoa
varicocele
varicocelectomy
Journal
Frontiers in reproductive health
ISSN: 2673-3153
Titre abrégé: Front Reprod Health
Pays: Switzerland
ID NLM: 9918230899006676
Informations de publication
Date de publication:
2022
2022
Historique:
received:
08
11
2021
accepted:
10
03
2022
entrez:
28
10
2022
pubmed:
29
10
2022
medline:
29
10
2022
Statut:
epublish
Résumé
The knowledge on male reproduction is constantly expanding, especially in treating infertility due to non-obstructive azoospermia (NOA). Varicocele is occasionally diagnosed in a subpopulation of males with NOA. Varicocele repair in NOA-men may contribute to the reappearance of spermatozoa in semen. However, spontaneous pregnancies are observed in only a small percentage of NOA-men post-varicocelectomy. Additionally, it has been reported that the repair of varicocele in NOA-men (before the performance of sperm retrieval techniques) may increase the testicular sperm recovery rate. In addition, it increases the pregnancy rate in intracytoplasmic sperm injection (ICSI) programs in NOA-men without spermatozoa in the semen post-varicocelectomy. In addition, to the improvement in Sertoli cellular secretory function, varicocelectomy may increase the secretory function of Leydig cells, which subsequently results in improved androgen production, raising the probability to negate the need for testosterone replacement therapy in cases of late-onset hypogonadism. On the other hand, the benefit of varicocelectomy in patients with NOA is still debatable. The current review study aims to provide a critical and extensive review of varicocele repair in males with NOA. This study additionally focuses on the impact of varicocele repair on sperm retrieval rates and its influence on the ICSI outcomes for those couples who remain negative for spermatozoa in their semen samples post-varicocelectomy.
Identifiants
pubmed: 36303681
doi: 10.3389/frph.2022.811487
pmc: PMC9580802
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
811487Informations de copyright
Copyright © 2022 Kaltsas, Markou, Zachariou, Dimitriadis, Mamoulakis, Andreadakis, Giannakis, Tsounapi, Takenaka and Sofikitis.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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