Differential Interactome Based Drug Repositioning Unraveled Abacavir, Exemestane, Nortriptyline Hydrochloride, and Tolcapone as Potential Therapeutics for Colorectal Cancers.
colorectal cancer
differential interactome
drug repositioning
prognostic markers
systems biomarkers
Journal
Frontiers in bioinformatics
ISSN: 2673-7647
Titre abrégé: Front Bioinform
Pays: Switzerland
ID NLM: 9918227263306676
Informations de publication
Date de publication:
2021
2021
Historique:
received:
16
05
2021
accepted:
01
09
2021
entrez:
28
10
2022
pubmed:
29
10
2022
medline:
29
10
2022
Statut:
epublish
Résumé
There is a critical requirement for alternative strategies to provide the better treatment in colorectal cancer (CRC). Hence, our goal was to propose novel biomarkers as well as drug candidates for its treatment through differential interactome based drug repositioning. Differentially interacting proteins and their modules were identified, and their prognostic power were estimated through survival analyses. Drug repositioning was carried out for significant target proteins, and candidate drugs were analyzed via in silico molecular docking prior to
Identifiants
pubmed: 36303724
doi: 10.3389/fbinf.2021.710591
pii: 710591
pmc: PMC9581026
doi:
Types de publication
Journal Article
Langues
eng
Pagination
710591Informations de copyright
Copyright © 2021 Beklen, Arslan, Gulfidan, Turanli, Ozbek, Karademir Yilmaz and Arga.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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