AMPK activation is sufficient to increase skeletal muscle glucose uptake and glycogen synthesis but is not required for contraction-mediated increases in glucose metabolism.
AMPK
Metabolism
Pharmacology
Skeletal muscle
Journal
Heliyon
ISSN: 2405-8440
Titre abrégé: Heliyon
Pays: England
ID NLM: 101672560
Informations de publication
Date de publication:
Oct 2022
Oct 2022
Historique:
received:
21
09
2021
revised:
13
12
2021
accepted:
10
10
2022
entrez:
28
10
2022
pubmed:
29
10
2022
medline:
29
10
2022
Statut:
epublish
Résumé
The AMP-activated protein kinase (AMPK) is a cellular sensor of energetics and when activated in skeletal muscle during contraction can impart changes in skeletal muscle metabolism. Therapeutics that selectively activate AMPK have been developed to lower glucose levels through increased glucose disposal rates as an approach to abrogate the hyperglycemic state of diabetes; however, the metabolic fate of glucose following AMPK activation remains unclear. We have used a combination of
Identifiants
pubmed: 36303906
doi: 10.1016/j.heliyon.2022.e11091
pii: S2405-8440(22)02379-9
pmc: PMC9593205
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e11091Informations de copyright
© 2022 The Authors.
Déclaration de conflit d'intérêts
The authors declare the following conflict of interests: Some of the authors on this manuscript were employees of Pfizer Inc. during the studies reported.
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