Regional and National Trends of Adult Living Donor Liver Transplantation in the United States Over the Last Two Decades.
Liver transplantation
Living donor
Organ demand
Survival
UNOS
Journal
Journal of clinical and translational hepatology
ISSN: 2310-8819
Titre abrégé: J Clin Transl Hepatol
Pays: United States
ID NLM: 101649815
Informations de publication
Date de publication:
28 Oct 2022
28 Oct 2022
Historique:
received:
30
11
2021
revised:
26
01
2022
accepted:
15
02
2022
entrez:
28
10
2022
pubmed:
29
10
2022
medline:
29
10
2022
Statut:
ppublish
Résumé
Liver organ shortage remains a major health burden in the US, with more patients being waitlisted than the number of liver transplants (LTs) performed. This study investigated US national and regional trends in living donor LT (LDLT) and identified factors associated with recipient survival. We retrospectively analyzed LDLT recipients and donors from the United Network Organ Sharing/Organ Procurement Transplant Network database from 1998 until 2019 for clinical characteristics, demographic differences, and survival rate. National and regional trends in LDLT, recipient outcomes, and predictors of survival were analyzed. Of the 223,571 candidates listed for an LT, 57.5% received an organ, of which only 4.2% were LDLTs. Annual adult LDLTs first peaked at 412 in 2001 but experienced a significant decline to 168 by 2009. LDLTs then gradually increased to 445 in 2019. Region 2 had the highest LDLT numbers ( Following a substantial decline after a peak in 2001, the number of adult LDLTs steadily increased from 2011 to 2019. However, LDLTs still constitute the minority of the transplant pool in the US. Life-saving policies to increase the use of LDLTs, particularly in regions of high organ demand, should be implemented.
Sections du résumé
Background and Aims
UNASSIGNED
Liver organ shortage remains a major health burden in the US, with more patients being waitlisted than the number of liver transplants (LTs) performed. This study investigated US national and regional trends in living donor LT (LDLT) and identified factors associated with recipient survival.
Methods
UNASSIGNED
We retrospectively analyzed LDLT recipients and donors from the United Network Organ Sharing/Organ Procurement Transplant Network database from 1998 until 2019 for clinical characteristics, demographic differences, and survival rate. National and regional trends in LDLT, recipient outcomes, and predictors of survival were analyzed.
Results
UNASSIGNED
Of the 223,571 candidates listed for an LT, 57.5% received an organ, of which only 4.2% were LDLTs. Annual adult LDLTs first peaked at 412 in 2001 but experienced a significant decline to 168 by 2009. LDLTs then gradually increased to 445 in 2019. Region 2 had the highest LDLT numbers (
Conclusions
UNASSIGNED
Following a substantial decline after a peak in 2001, the number of adult LDLTs steadily increased from 2011 to 2019. However, LDLTs still constitute the minority of the transplant pool in the US. Life-saving policies to increase the use of LDLTs, particularly in regions of high organ demand, should be implemented.
Identifiants
pubmed: 36304492
doi: 10.14218/JCTH.2021.00538
pii: JCTH.2021.00538
pmc: PMC9547266
doi:
Types de publication
Journal Article
Langues
eng
Pagination
814-824Informations de copyright
© 2022 Authors.
Déclaration de conflit d'intérêts
AB declares activities with Scientific Advisory Boards, Intercept, Primary Investigator for trials for Gilead and CARA. BS has been an editorial board member of Journal of Clinical and Translational Hepatology since 2016. All other authors have no conflict of interests related to this publication.
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