Cefazolin-induced hypoprothrombinemia.
Cefazolin
cephalosporin
coagulopathy
Journal
Proceedings (Baylor University. Medical Center)
ISSN: 0899-8280
Titre abrégé: Proc (Bayl Univ Med Cent)
Pays: United States
ID NLM: 9302033
Informations de publication
Date de publication:
2022
2022
Historique:
entrez:
28
10
2022
pubmed:
29
10
2022
medline:
29
10
2022
Statut:
epublish
Résumé
Long-term antibiotic use can be associated with a myriad of side effects, ranging from relatively benign to life-threatening. The most common side effects of cephalosporins include dermatologic reactions and diarrhea. Here, we present a rarer side effect: a spontaneous retroperitoneal hematoma in the setting of cefazolin administration for vertebral osteomyelitis. Several cephalosporins have been implicated in coagulopathy secondary to hypoprothrombinemia. However, only a few case reports have implicated cefazolin, and all have occurred in the context of acute or chronic renal failure. Our case of cefazolin-induced coagulopathy occurred in a patient with normal renal function.
Identifiants
pubmed: 36304595
doi: 10.1080/08998280.2022.2095859
pii: 2095859
pmc: PMC9586601
doi:
Types de publication
Case Reports
Langues
eng
Pagination
868-870Informations de copyright
Copyright © 2022 Baylor University Medical Center.
Références
Am J Health Syst Pharm. 2008 May 1;65(9):823-6
pubmed: 18436729
J Pharmacol Exp Ther. 1985 Nov;235(2):382-8
pubmed: 2865352
J Clin Pharmacol. 1988 Jan;28(1):88-95
pubmed: 3350995
Antimicrob Agents Chemother. 1987 Feb;31(2):281-5
pubmed: 3471181
Aust N Z J Surg. 1991 Jun;61(6):471-2
pubmed: 2059184
Drug Metab Dispos. 2002 Oct;30(10):1123-8
pubmed: 12228189
Ann Pharmacother. 2014 May 20;48(9):1214-1218
pubmed: 24847158
J Antimicrob Chemother. 1984 Sep;14 Suppl B:325-30
pubmed: 6389475
Ann Clin Res. 1985;17(3):116-9
pubmed: 4051444
Anaesth Crit Care Pain Med. 2018 Apr;37(2):167-170
pubmed: 28870850
Am J Health Syst Pharm. 2021 Dec 9;78(24):2204-2208
pubmed: 34000006