Lipoprotein-associated Phospholipase A2 in Coronary Artery Disease.

Biomarker Coronary heart disease Endothelial dysfunction Lipoproteins Lp-PLA2 Mortality. Outcome

Journal

Current topics in medicinal chemistry
ISSN: 1873-4294
Titre abrégé: Curr Top Med Chem
Pays: United Arab Emirates
ID NLM: 101119673

Informations de publication

Date de publication:
2022
Historique:
received: 01 06 2022
revised: 03 10 2022
accepted: 12 10 2022
medline: 29 10 2022
pubmed: 29 10 2022
entrez: 28 10 2022
Statut: ppublish

Résumé

Coronary artery disease (CAD) is the leading cause of morbidity and mortality in western societies. Therefore the identification of novel biomarkers to be used as diagnostic or therapeutic targets is of significant scientific interest. Lipoprotein-associated phospholipase A2 (Lp-PLA2) is one such protein shown to be involved in endothelial dysfunction, vascular inflammation and atherogenesis. Several epidemiological studies have associated high Lp-PLA2 activity with an increased risk for CAD even when other CAD risk factors or inflammation markers were included in the multivariate analysis. These findings were strengthened by the results of relevant meta-analyses. However, randomized trials failed to establish Lp-PLA2 as a therapeutic target. Specifically, pharmaceutical inhibition of Lp-PLA2 when compared to the placebo failed to demonstrate a significant association with improved prognosis of patients with stable CAD or after an acute coronary syndrome (ACS). This review focuses on the available data that have investigated the potential role of Lp- PLA2 as a biomarker for CAD.

Identifiants

pubmed: 36305124
pii: CTMC-EPUB-127246
doi: 10.2174/1568026623666221027145545
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

2344-2354

Informations de copyright

Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.

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Auteurs

Yannis Dimitroglou (Y)

First Cardiology Department, Hippokration General Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece.

Athanasios Sakalidis (A)

First Cardiology Department, Hippokration General Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece.

Andreas Mavroudis (A)

First Cardiology Department, Hippokration General Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece.

Charalambos Kalantzis (C)

First Cardiology Department, Hippokration General Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece.

Angeliki Valatsou (A)

First Cardiology Department, Hippokration General Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece.

Ioannis Andrikou (I)

First Cardiology Department, Hippokration General Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece.

Angela Christofi (A)

First Cardiology Department, Hippokration General Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece.

Emmanouil Mantzouranis (E)

First Cardiology Department, Hippokration General Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece.

Ioannis Kachrimanidis (I)

First Cardiology Department, Hippokration General Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece.

Evellina Bei (E)

First Cardiology Department, Hippokration General Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece.

Emilia Lazarou (E)

First Cardiology Department, Hippokration General Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece.

Costas Tsioufis (C)

First Cardiology Department, Hippokration General Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece.

Dimitris Tousoulis (D)

First Cardiology Department, Hippokration General Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece.

George Lazaros (G)

First Cardiology Department, Hippokration General Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece.

Classifications MeSH