Evidence that complement and coagulation proteins are mediating the clinical response to omega-3 fatty acids: A mass spectrometry-based investigation in subjects at clinical high-risk for psychosis.
Journal
Translational psychiatry
ISSN: 2158-3188
Titre abrégé: Transl Psychiatry
Pays: United States
ID NLM: 101562664
Informations de publication
Date de publication:
28 10 2022
28 10 2022
Historique:
received:
11
03
2022
accepted:
04
10
2022
revised:
21
09
2022
pubmed:
29
10
2022
medline:
2
11
2022
entrez:
28
10
2022
Statut:
epublish
Résumé
Preliminary evidence indicates beneficial effects of omega-3 polyunsaturated fatty acids (PUFAs) in early psychosis. The present study investigates the molecular mechanism of omega-3 PUFA-associated therapeutic effects in clinical high-risk (CHR) participants. Plasma samples of 126 CHR psychosis participants at baseline and 6-months follow-up were included. Plasma protein levels were quantified using mass spectrometry and erythrocyte omega-3 PUFA levels were quantified using gas chromatography. We examined the relationship between change in polyunsaturated PUFAs (between baseline and 6-month follow-up) and follow-up plasma proteins. Using mediation analysis, we investigated whether plasma proteins mediated the relationship between change in omega-3 PUFAs and clinical outcomes. A 6-months change in omega-3 PUFAs was associated with 24 plasma proteins at follow-up. Pathway analysis revealed the complement and coagulation pathway as the main biological pathway to be associated with change in omega-3 PUFAs. Moreover, complement and coagulation pathway proteins significantly mediated the relationship between change in omega-3 PUFAs and clinical outcome at follow-up. The inflammatory protein complement C5 and protein S100A9 negatively mediated the relationship between change in omega-3 PUFAs and positive symptom severity, while C5 positively mediated the relationship between change in omega-3 and functional outcome. The relationship between change in omega-3 PUFAs and cognition was positively mediated through coagulation factor V and complement protein C1QB. Our findings provide evidence for a longitudinal association of omega-3 PUFAs with complement and coagulation protein changes in the blood. Further, the results suggest that an increase in omega-3 PUFAs decreases symptom severity and improves cognition in the CHR state through modulating effects of complement and coagulation proteins.
Identifiants
pubmed: 36307392
doi: 10.1038/s41398-022-02217-0
pii: 10.1038/s41398-022-02217-0
pmc: PMC9616837
doi:
Substances chimiques
Fatty Acids, Omega-3
0
Fatty Acids, Unsaturated
0
Complement System Proteins
9007-36-7
Banques de données
ANZCTR
['12608000475347']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
454Subventions
Organisme : Health Research Board
ID : HRB ILP POR 2019-005
Pays : Ireland
Organisme : Health Research Board
ID : HRB/HRA/PHR/2015-1293
Pays : Ireland
Organisme : Science Foundation Ireland
ID : 16/RC/3948
Pays : Ireland
Organisme : Wellcome Trust
ID : 220438Z/20/Z
Pays : United Kingdom
Informations de copyright
© 2022. The Author(s).
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