Polygenic association of glomerular filtration rate decline in world trade center responders.
Chronic kidney disease (CKD)
Estimated glomerular filtration rate (eGFR)
Polygenic risk score (PRS)
Journal
BMC nephrology
ISSN: 1471-2369
Titre abrégé: BMC Nephrol
Pays: England
ID NLM: 100967793
Informations de publication
Date de publication:
28 10 2022
28 10 2022
Historique:
received:
30
04
2022
accepted:
06
10
2022
revised:
26
09
2022
entrez:
29
10
2022
pubmed:
30
10
2022
medline:
2
11
2022
Statut:
epublish
Résumé
The factors associated with estimated glomerular filtrate rate (eGFR) decline in low risk adults remain relatively unknown. We hypothesized that a polygenic risk score (PRS) will be associated with eGFR decline. We analyzed genetic data from 1,601 adult participants with European ancestry in the World Trade Center Health Program (baseline age 49.68 ± 8.79 years, 93% male, 23% hypertensive, 7% diabetic and 1% with cardiovascular disease) with ≥ three serial measures of serum creatinine. PRSs were calculated from an aggregation of single nucleotide polymorphisms (SNPs) from a recent, large-scale genome-wide association study (GWAS) of rapid eGFR decline. Generalized linear models were used to evaluate the association of PRS with renal outcomes: baseline eGFR and CKD stage, rate of change in eGFR, stable versus declining eGFR over a 3-5-year observation period. eGFR decline was defined in separate analyses as "clinical" (> -1.0 ml/min/1.73 m The mean baseline eGFR was ~ 86 ml/min/1.73 m Common genetic variants are associated with eGFR decline in middle-aged adults with relatively low comorbidity burdens.
Sections du résumé
BACKGROUND
The factors associated with estimated glomerular filtrate rate (eGFR) decline in low risk adults remain relatively unknown. We hypothesized that a polygenic risk score (PRS) will be associated with eGFR decline.
METHODS
We analyzed genetic data from 1,601 adult participants with European ancestry in the World Trade Center Health Program (baseline age 49.68 ± 8.79 years, 93% male, 23% hypertensive, 7% diabetic and 1% with cardiovascular disease) with ≥ three serial measures of serum creatinine. PRSs were calculated from an aggregation of single nucleotide polymorphisms (SNPs) from a recent, large-scale genome-wide association study (GWAS) of rapid eGFR decline. Generalized linear models were used to evaluate the association of PRS with renal outcomes: baseline eGFR and CKD stage, rate of change in eGFR, stable versus declining eGFR over a 3-5-year observation period. eGFR decline was defined in separate analyses as "clinical" (> -1.0 ml/min/1.73 m
RESULTS
The mean baseline eGFR was ~ 86 ml/min/1.73 m
CONCLUSION
Common genetic variants are associated with eGFR decline in middle-aged adults with relatively low comorbidity burdens.
Identifiants
pubmed: 36307804
doi: 10.1186/s12882-022-02967-5
pii: 10.1186/s12882-022-02967-5
pmc: PMC9615399
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
347Subventions
Organisme : NIMH NIH HHS
ID : R01 MH123619
Pays : United States
Organisme : NIOSH CDC HHS
ID : R21 OH012237
Pays : United States
Organisme : NIOSH CDC HHS
ID : U01 OH011864
Pays : United States
Informations de copyright
© 2022. The Author(s).
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