Human amniotic epithelial cells exert anti-cancer effects through secretion of immunomodulatory small extracellular vesicles (sEV).
Cancer
Cytotoxic T lymphocyte
Human amniotic epithelial cell
Metabolomics
Small extracellular vesicles (sEV)
Stem cells
Warburg’s effect
Journal
Cancer cell international
ISSN: 1475-2867
Titre abrégé: Cancer Cell Int
Pays: England
ID NLM: 101139795
Informations de publication
Date de publication:
29 Oct 2022
29 Oct 2022
Historique:
received:
23
02
2022
accepted:
15
10
2022
entrez:
29
10
2022
pubmed:
30
10
2022
medline:
30
10
2022
Statut:
epublish
Résumé
We identified here mechanism by which hAECs exert their anti-cancer effects. We showed that vaccination with live hAEC conferred effective protection against murine colon cancer and melanoma but not against breast cancer in an orthotopic cancer cell inoculation model. hAEC induced strong cross-reactive antibody response to CT26 cells, but not against B16F10 and 4T1 cells. Neither heterotopic injection of tumor cells in AEC-vaccinated mice nor vaccination with hAEC lysate conferred protection against melanoma or colon cancer. Nano-sized AEC-derived small-extracellular vesicles (sEV) (AD-sEV) induced apoptosis in CT26 cells and inhibited their proliferation. Co-administration of AD-sEV with tumor cells substantially inhibited tumor development and increased CTL responses in vaccinated mice. AD-sEV triggered the Warburg's effect leading to Arginine consumption and cancer cell apoptosis. Our results clearly showed that it is AD-sEV but not the cross-reactive immune responses against tumor cells that mediate inhibitory effects of hAEC on cancer development. Our results highlight the potential anti-cancer effects of extracellular vesicles derived from hAEC.
Identifiants
pubmed: 36307848
doi: 10.1186/s12935-022-02755-z
pii: 10.1186/s12935-022-02755-z
pmc: PMC9616706
doi:
Types de publication
Journal Article
Langues
eng
Pagination
329Subventions
Organisme : Iran University of Medical Sciences
ID : IR.IUMS.REC.1395.28042
Organisme : Iran University of Medical Sciences
ID : IR.IUMS.REC.1395.28042
Organisme : Iran University of Medical Sciences
ID : IR.IUMS.REC.1395.28042
Organisme : Iran University of Medical Sciences
ID : IR.IUMS.REC.1395.28042
Organisme : Iran University of Medical Sciences
ID : IR.IUMS.REC.1395.28042
Organisme : Iran University of Medical Sciences
ID : IR.IUMS.REC.1395.28042
Informations de copyright
© 2022. The Author(s).
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