Association of blood-based biomarkers with radiologic markers and cognitive decline in atrial fibrillation patients.
Atrial fibrillation
Biomarkers
Cognitive decline
Radiological marker
Silent brain injury
Journal
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
ISSN: 1532-8511
Titre abrégé: J Stroke Cerebrovasc Dis
Pays: United States
ID NLM: 9111633
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
received:
16
08
2022
revised:
28
09
2022
accepted:
11
10
2022
pubmed:
30
10
2022
medline:
24
11
2022
entrez:
29
10
2022
Statut:
ppublish
Résumé
Atrial fibrillation (AF) has been associated with an increased risk of silent brain infarcts (SBI) and cognitive impairment, even in patients with low embolic risk. We aimed to test the association between 11 blood-biomarkers representing different AF-related pathways, and SBI, white matter hyperintensities (WMH), and cognitive decline in patients with AF and low embolic risk. The present study followed a cross-sectional design. 70 patients with a history of AF and CHADS 45 patients presented SBI in the MRI, and 25 did not. Ang-2, FGF-23, and BMP-10 were increased in patients with SBI. Ang-2 was elevated only in patients with embolic infarcts, whereas FGF-23 and BMP-10 tended to be elevated in patients with both types of infarcts. Ang-2 (OR = 1.56 [0.94-2.59], p = 0.087), and BMP-10 (OR = 4.83 [0.99-23.60], p = 0.052) were the biomarkers that showed the highest association with SBI when entered in a multivariable logistic regression model corrected by age. No biomarker was found associated with WMH or mild cognitive impairment. BMP-10, and Ang-2 were increased in patients with SBI. Its usefulness to detect SBI in AF patients should be further explored.
Sections du résumé
BACKGROUND
BACKGROUND
Atrial fibrillation (AF) has been associated with an increased risk of silent brain infarcts (SBI) and cognitive impairment, even in patients with low embolic risk. We aimed to test the association between 11 blood-biomarkers representing different AF-related pathways, and SBI, white matter hyperintensities (WMH), and cognitive decline in patients with AF and low embolic risk.
METHODS
METHODS
The present study followed a cross-sectional design. 70 patients with a history of AF and CHADS
RESULTS
RESULTS
45 patients presented SBI in the MRI, and 25 did not. Ang-2, FGF-23, and BMP-10 were increased in patients with SBI. Ang-2 was elevated only in patients with embolic infarcts, whereas FGF-23 and BMP-10 tended to be elevated in patients with both types of infarcts. Ang-2 (OR = 1.56 [0.94-2.59], p = 0.087), and BMP-10 (OR = 4.83 [0.99-23.60], p = 0.052) were the biomarkers that showed the highest association with SBI when entered in a multivariable logistic regression model corrected by age. No biomarker was found associated with WMH or mild cognitive impairment.
CONCLUSIONS
CONCLUSIONS
BMP-10, and Ang-2 were increased in patients with SBI. Its usefulness to detect SBI in AF patients should be further explored.
Identifiants
pubmed: 36309005
pii: S1052-3057(22)00527-4
doi: 10.1016/j.jstrokecerebrovasdis.2022.106833
pii:
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
106833Informations de copyright
Copyright © 2022 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest Neurovascular research laboratory, Vall d'Hebron Institute of Research (VHIR) received institutional research support from Roche Diagnostics that funded part of the present study. JM and AB have participated in scientific advisory boards organized by ROCHE on the topic of “New biomarkers in Atrial Fibrillation”.