Genomic Characterization of Prostatic Basal Cell Carcinoma.
Journal
The American journal of pathology
ISSN: 1525-2191
Titre abrégé: Am J Pathol
Pays: United States
ID NLM: 0370502
Informations de publication
Date de publication:
01 2023
01 2023
Historique:
received:
11
08
2022
revised:
13
09
2022
accepted:
30
09
2022
pmc-release:
01
01
2024
pubmed:
30
10
2022
medline:
20
12
2022
entrez:
29
10
2022
Statut:
ppublish
Résumé
Basal cell carcinoma (BCC) of the prostate is a rare tumor. Compared with the more common acinar adenocarcinoma (AAC) of the prostate, BCCs show features of basal cell differentiation and are thought to be biologically distinct from AAC. The spectrum of molecular alterations of BCC has not been comprehensively described, and genomic studies are lacking. Herein, whole genome sequencing was performed on archival formalin-fixed, paraffin-embedded specimens of two cases with BCC. Prostatic BCCs were characterized by an overall low copy number and mutational burden. Recurrent copy number loss of chromosome 16 was observed. In addition, putative driver gene alterations in KIT, DENND3, PTPRU, MGA, and CYLD were identified. Mechanistically, depletion of the CYLD protein resulted in increased proliferation of prostatic basal cells in vitro. Collectively, these studies show that prostatic BCC displays distinct genomic alterations from AAC and highlight a potential role for loss of chromosome 16 in the pathogenesis of this rare tumor type.
Identifiants
pubmed: 36309102
pii: S0002-9440(22)00320-0
doi: 10.1016/j.ajpath.2022.09.010
pmc: PMC9768679
pii:
doi:
Substances chimiques
PTPRU protein, human
EC 3.1.3.48
Receptor-Like Protein Tyrosine Phosphatases, Class 2
EC 3.1.3.48
DENND3 protein, human
0
Guanine Nucleotide Exchange Factors
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4-10Subventions
Organisme : NCI NIH HHS
ID : P50 CA058236
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA006973
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA097186
Pays : United States
Organisme : NIH HHS
ID : S10 OD028685
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA234715
Pays : United States
Organisme : NCI NIH HHS
ID : K22 CA237746
Pays : United States
Organisme : NCI NIH HHS
ID : U54 CA224079
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA163227
Pays : United States
Informations de copyright
Copyright © 2023 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.
Références
Cancer Cell. 2002 Aug;2(2):157-64
pubmed: 12204536
Hum Pathol. 1988 Dec;19(12):1425-33
pubmed: 2461340
Hum Pathol. 2015 Aug;46(8):1204-8
pubmed: 26089205
Nat Genet. 2011 May;43(5):491-8
pubmed: 21478889
Cell. 2018 Jul 12;174(2):433-447.e19
pubmed: 29909985
Trends Cancer. 2018 Nov;4(11):769-783
pubmed: 30352679
Int J Clin Exp Pathol. 2014 Aug 15;7(9):5750-61
pubmed: 25337216
Nat Rev Urol. 2016 Jul;13(7):409-19
pubmed: 27296647
PLoS One. 2013 Jul 08;8(7):e70339
pubmed: 23861985
Am J Surg Pathol. 2007 May;31(5):697-705
pubmed: 17460452
Cell. 2015 May 21;161(5):1215-1228
pubmed: 26000489
Oncogene. 2005 Jun 16;24(26):4271-80
pubmed: 15824741
Neuron. 2011 Oct 20;72(2):257-68
pubmed: 21944779
Bioinformatics. 2009 Jul 15;25(14):1754-60
pubmed: 19451168
Cancer Prev Res (Phila). 2016 Apr;9(4):265-74
pubmed: 26862087
Cancers Head Neck. 2016 Sep 8;1:10
pubmed: 31093340
Carcinogenesis. 2014 Aug;35(8):1901-10
pubmed: 24876153
J Biol Chem. 2004 Dec 31;279(53):55161-7
pubmed: 15496400
Oncogene. 2010 Dec 16;29(50):6522-32
pubmed: 20838385
Mol Cancer Res. 2020 Apr;18(4):574-584
pubmed: 31862696
Virchows Arch. 2005 Mar;446(3):338-41
pubmed: 15726402
Prostate. 2017 Mar;77(4):374-384
pubmed: 27859428
Nat Rev Clin Oncol. 2016 May;13(5):305-18
pubmed: 26620272
Nat Commun. 2017 Nov 6;8(1):1324
pubmed: 29109393
Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):20111-6
pubmed: 24282295
Am J Surg Pathol. 2004 Oct;28(10):1289-98
pubmed: 15371944
Genome Res. 2014 Nov;24(11):1881-93
pubmed: 25060187
BJU Int. 2007 Jun;99(6):1345-9
pubmed: 17419700
J Biol Chem. 2017 Apr 28;292(17):7274-7282
pubmed: 28249939
Mod Pathol. 2019 Nov;32(11):1666-1674
pubmed: 31189999
Nature. 2003 Aug 14;424(6950):801-5
pubmed: 12917691
Nat Genet. 2000 Jun;25(2):160-5
pubmed: 10835629
Science. 2010 Jul 30;329(5991):568-71
pubmed: 20671189
EMBO J. 1999 Dec 15;18(24):7019-28
pubmed: 10601024
Elife. 2021 Jul 08;10:
pubmed: 34236315
J Pathol. 2013 Jun;230(2):174-83
pubmed: 23447416
Prostate. 2020 May;80(6):508-517
pubmed: 32119131
Nucleic Acids Res. 2021 Jan 8;49(D1):D884-D891
pubmed: 33137190
Am J Pathol. 1998 Sep;153(3):911-9
pubmed: 9736039
Cancer Discov. 2012 May;2(5):401-4
pubmed: 22588877
Nat Genet. 2018 May;50(5):682-692
pubmed: 29662167
Lancet Oncol. 2015 Sep;16(9):e460-e469
pubmed: 26370355
Am J Surg Pathol. 2003 Dec;27(12):1523-9
pubmed: 14657711
Int J Urol. 2014 Oct;21(10):1072-3
pubmed: 24862035
Nat Genet. 2018 May;50(5):645-651
pubmed: 29610475
Hum Pathol. 1998 Dec;29(12):1447-50
pubmed: 9865831
Nat Methods. 2018 Aug;15(8):591-594
pubmed: 30013048
Cell. 2015 Nov 5;163(4):1011-25
pubmed: 26544944
Nature. 2003 Aug 14;424(6950):797-801
pubmed: 12917690
Hum Pathol. 2002 May;33(5):484-95
pubmed: 12094373
Nat Rev Cancer. 2011 Nov 17;11(12):865-78
pubmed: 22089421
Cell. 1993 Jan 29;72(2):233-45
pubmed: 8425220
J Craniomaxillofac Surg. 2013 Sep;41(6):516-21
pubmed: 23260808
Sci Signal. 2013 Apr 02;6(269):pl1
pubmed: 23550210
Genome Res. 2018 Apr;28(4):581-591
pubmed: 29535149
PLoS One. 2015 Feb 18;10(2):e0117758
pubmed: 25693195
Mod Pathol. 2003 Jun;16(6):598-606
pubmed: 12808066
Cold Spring Harb Perspect Med. 2017 Oct 3;7(10):
pubmed: 28389514
Nat Genet. 2010 Aug;42(8):668-75
pubmed: 20601956