Tertiary lymphoid structures associate with improved survival in early oral tongue cancer.

Humans Tongue Neoplasms / pathology Tertiary Lymphoid Structures / pathology Carcinoma, Squamous Cell / pathology Mouth Neoplasms Squamous Cell Carcinoma of Head and Neck Prognosis Head and Neck Neoplasms
Early stage Oral tongue cancer Survival Tertiary lymphoid structures

Journal

BMC cancer
ISSN: 1471-2407
Titre abrégé: BMC Cancer
Pays: England
ID NLM: 100967800

Informations de publication

Date de publication:
30 Oct 2022
Historique:
received: 05 04 2022
accepted: 20 10 2022
entrez: 30 10 2022
pubmed: 31 10 2022
medline: 2 11 2022
Statut: epublish

Résumé

The clinical significance of tertiary lymphoid structures (TLSs) is not well-documented in early oral tongue squamous cell carcinoma (OTSCC). A total of 310 cases of early (cT1-2N0) OTSCC were included in this multicenter study. Assessment of TLSs was conducted on hematoxylin and eosin-stained sections. TLSs were assessed both in the central part of the tumor and at the invasive front area. The presence of TLSs associated with improved survival of early OTSCC as presented by Kaplan-Meier survival analyses for disease-specific survival (P = 0.01) and overall survival (P = 0.006). In multivariable analyses, which included conventional prognostic factors, the absence of TLSs associated with worse disease-specific survival with a hazard ratio (HR) of 1.96 (95% CI 1.09-3.54; P = 0.025) and poor overall survival (HR 1.66, 95% CI 1.11-2.48; P = 0.014). Histological evaluation of TLSs predicts survival in early OTSCC. TLSs showed superior prognostic power independent of routine WHO grading and TNM staging system.

Sections du résumé

BACKGROUND BACKGROUND
The clinical significance of tertiary lymphoid structures (TLSs) is not well-documented in early oral tongue squamous cell carcinoma (OTSCC).
METHODS METHODS
A total of 310 cases of early (cT1-2N0) OTSCC were included in this multicenter study. Assessment of TLSs was conducted on hematoxylin and eosin-stained sections. TLSs were assessed both in the central part of the tumor and at the invasive front area.
RESULTS RESULTS
The presence of TLSs associated with improved survival of early OTSCC as presented by Kaplan-Meier survival analyses for disease-specific survival (P = 0.01) and overall survival (P = 0.006). In multivariable analyses, which included conventional prognostic factors, the absence of TLSs associated with worse disease-specific survival with a hazard ratio (HR) of 1.96 (95% CI 1.09-3.54; P = 0.025) and poor overall survival (HR 1.66, 95% CI 1.11-2.48; P = 0.014).
CONCLUSION CONCLUSIONS
Histological evaluation of TLSs predicts survival in early OTSCC. TLSs showed superior prognostic power independent of routine WHO grading and TNM staging system.

Identifiants

DOI: 10.1186/s12885-022-10208-z PMID: 36309667 PMC: PMC9618224
pubmed: 36309667
doi: 10.1186/s12885-022-10208-z
pii: 10.1186/s12885-022-10208-z
pmc: PMC9618224
doi:

Types de publication

Multicenter Study Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1108

Informations de copyright

© 2022. The Author(s).

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Auteurs

Alhadi Almangush (A)

Department of Pathology, University of Helsinki, Haartmaninkatu 3, P.O. Box 21, Helsinki, N00014, Finland. alhadi.almangush@helsinki.fi.
Faculty of Medicine, Research Program in Systems Oncology, University of Helsinki, Helsinki, Finland. alhadi.almangush@helsinki.fi.
Institute of Biomedicine, Pathology, University of Turku, Turku, Finland. alhadi.almangush@helsinki.fi.
Faculty of Dentistry, Misurata University, Misurata, Libya. alhadi.almangush@helsinki.fi.

Ibrahim O Bello (IO)

Department of Pathology, University of Helsinki, Haartmaninkatu 3, P.O. Box 21, Helsinki, N00014, Finland.
Department of Oral Medicine and Diagnostic Sciences, King Saud University College of Dentistry, Riyadh, Saudi Arabia.

Amr Elseragy (A)

Cancer and Translational Medicine Research Unit, University of Oulu, 90014, Oulu, Finland.
Department of Oral and Maxillofacial Diseases, University of Helsinki, Helsinki, Finland.

Jaana Hagström (J)

Department of Pathology, University of Helsinki, Haartmaninkatu 3, P.O. Box 21, Helsinki, N00014, Finland.
Research Programs Unit, Translational Cancer Medicine, University of Helsinki, Helsinki, Finland.
Department of Oral Pathology and Radiology, University of Turku, Turku, Finland.

Caj Haglund (C)

Research Programs Unit, Translational Cancer Medicine, University of Helsinki, P.O. Box 63, 00014, Helsinki, Finland.
Department of Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Luiz Paulo Kowalski (LP)

Department of Head and Neck Surgery and Otorhinolaryngology, A.C. Camargo Cancer Center, and University of Sao Paulo Medical School, Department of Head and Neck Surgery, São Paulo, SP, 05402-000, Brazil.

Pentti Nieminen (P)

Medical Informatics and Data Analysis Research Group, University of Oulu, Oulu, Finland.

Ricardo D Coletta (RD)

Department of Oral Diagnosis and Graduate Program in Oral Biology, School of Dentistry, University of Campinas, Piracicaba, São Paulo, 13414-018, Brazil.

Antti A Mäkitie (AA)

Faculty of Medicine, Research Program in Systems Oncology, University of Helsinki, Helsinki, Finland.
Department of Otorhinolaryngology - Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, P.O. Box 263, 00029, Helsinki, Finland.
Department of Clinical Sciences, Intervention and Technology, Division of Ear, Nose and Throat Diseases, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.

Tuula Salo (T)

Department of Pathology, University of Helsinki, Haartmaninkatu 3, P.O. Box 21, Helsinki, N00014, Finland.
Department of Oral and Maxillofacial Diseases, University of Helsinki, Helsinki, Finland.

Ilmo Leivo (I)

Institute of Biomedicine, Pathology, University of Turku, 20520, Turku, Finland.
Turku University Central Hospital, Turku, Finland.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Tertiary lymphoid structures associate with...
questionsmedicales.fr › Maladies du système stomatognathique › Maladies de la bouche › Maladies de la langue › Tumeurs de la langue › Tertiary lymphoid structures associate with...
questionsmedicales.fr › États, signes et symptômes pathologiques › États anatomopathologiques › Structures lymphoïdes tertiaires › Tertiary lymphoid structures associate with...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs épithéliales épidermoïdes et glandulaires › Tumeurs épidermoïdes › Carcinome épidermoïde › Tertiary lymphoid structures associate with...
questionsmedicales.fr › Maladies du système stomatognathique › Maladies de la bouche › Tumeurs de la bouche › Tertiary lymphoid structures associate with...
questionsmedicales.fr › Tumeurs › Tumeurs par siège › Tumeurs de la tête et du cou › Carcinome épidermoïde de la tête et du cou › Tertiary lymphoid structures associate with...
questionsmedicales.fr › Diagnostic › Pronostic › Tertiary lymphoid structures associate with...
questionsmedicales.fr › Tumeurs › Tumeurs par siège › Tumeurs de la tête et du cou › Tertiary lymphoid structures associate with...