Bile pigments in emergency and critical care medicine.
Antioxidant therapy
Bile pigments
Emergency and critical care medicine
Journal
European journal of medical research
ISSN: 2047-783X
Titre abrégé: Eur J Med Res
Pays: England
ID NLM: 9517857
Informations de publication
Date de publication:
29 Oct 2022
29 Oct 2022
Historique:
received:
24
08
2022
accepted:
20
10
2022
entrez:
30
10
2022
pubmed:
31
10
2022
medline:
2
11
2022
Statut:
epublish
Résumé
Bile pigments, such as bilirubin and biliverdin, are end products of the heme degradation pathway in mammals and are widely known for their cytotoxic effects. However, recent studies have revealed that they exert cytoprotective effects through antioxidative, anti-inflammatory, and immunosuppressive properties. All these mechanisms are indispensable in the treatment of diseases in the field of emergency and critical care medicine, such as coronary ischemia, stroke, encephalomyelitis, acute lung injury/acute respiratory distress syndrome, mesenteric ischemia, and sepsis. While further research is required before the safe application of bile pigments in the clinical setting, their underlying mechanisms shed light on their utilization as therapeutic agents in the field of emergency and critical care medicine. This article aims to summarize the current understanding of bile pigments and re-evaluate their therapeutic potential in the diseases listed above.
Identifiants
pubmed: 36309733
doi: 10.1186/s40001-022-00863-0
pii: 10.1186/s40001-022-00863-0
pmc: PMC9618204
doi:
Substances chimiques
Bile Pigments
0
Biliverdine
O9MIA842K9
Antioxidants
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
224Informations de copyright
© 2022. The Author(s).
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