The role of plasminogen activator inhibitor-2 in pneumococcal meningitis.
Plasminogen activator inhibitor-2
Pneumococcal meningitis
SERPINB2
Journal
Acta neuropathologica communications
ISSN: 2051-5960
Titre abrégé: Acta Neuropathol Commun
Pays: England
ID NLM: 101610673
Informations de publication
Date de publication:
29 10 2022
29 10 2022
Historique:
received:
07
09
2022
accepted:
12
10
2022
entrez:
30
10
2022
pubmed:
31
10
2022
medline:
2
11
2022
Statut:
epublish
Résumé
Pneumococcal meningitis is associated with dysregulation of the coagulation cascade. Previously, we detected upregulation of cerebral plasminogen activator inhibitor-2 (PAI-2) mRNA expression during pneumococcal meningitis. Diverse functions have been ascribed to PAI-2, but its role remains unclear. We analyzed the function of SERPINB2 (coding for PAI-2) in patients with bacterial meningitis, in a well-established pneumococcal meningitis mouse model, using Serpinb2 knockout mice, and in vitro in wt and PAI-2-deficient bone marrow-derived macrophages (BMDMs). We measured PAI-2 in cerebrospinal fluid of patients, and performed functional, histopathological, protein and mRNA expression analyses in vivo and in vitro. We found a substantial increase of PAI-2 concentration in CSF of patients with pneumococcal meningitis, and up-regulation and increased release of PAI-2 in mice. PAI-2 deficiency was associated with increased mortality in murine pneumococcal meningitis and cerebral hemorrhages. Serpinb2
Identifiants
pubmed: 36309755
doi: 10.1186/s40478-022-01461-1
pii: 10.1186/s40478-022-01461-1
pmc: PMC9617400
doi:
Substances chimiques
Plasminogen Activator Inhibitor 2
0
Interleukin-10
130068-27-8
RNA, Messenger
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
155Informations de copyright
© 2022. The Author(s).
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