Perivascular epithelioid cell tumor (PEComa) of the cystic duct.
Bile duct
Cystic duct
Melanin
Mesenchymal tumor
TFE3
Journal
Clinical journal of gastroenterology
ISSN: 1865-7265
Titre abrégé: Clin J Gastroenterol
Pays: Japan
ID NLM: 101477246
Informations de publication
Date de publication:
Feb 2023
Feb 2023
Historique:
received:
01
09
2022
accepted:
23
10
2022
pubmed:
31
10
2022
medline:
3
2
2023
entrez:
30
10
2022
Statut:
ppublish
Résumé
Perivascular epithelioid cell tumors, also known as PEComas, are rare mesenchymal tumors composed mainly of epithelioid cells found in perivascular tissue. PEComas occur most frequently in the kidney, uterus, the gastrointestinal tract, liver, and retroperitoneum; those originating in the biliary tree are extremely rare. We report a case of benign PEComa of the cystic duct with positive TFE3 staining on immunohistochemistry.A 66-year-old woman was referred for a 20 mm mass adjacent to the common bile duct discovered incidentally on abdominal ultrasound. Laboratory data including tumor markers were unremarkable. The tumor appeared to arise from the cystic duct, showed early enhancement, and compressed the common bile duct on imaging studies. Endoscopic ultrasound-guided fine-needle aspiration revealed round- and spindle-shaped atypical cells with eosinophilic cytoplasm and brown deposits suggestive of melanin granules. Histological examination of the resected specimen revealed a tumor consisting of epithelioid cells forming an alveolar structure, with melanin pigmentation. Immunohistochemistry was positive for HMB-45 and TFE3, consistent with benign pigmented PEComa of the cystic duct. Melanotic, myogenic, and TFE3 staining are helpful when diagnosing PEComas arising in unusual locations.
Identifiants
pubmed: 36309916
doi: 10.1007/s12328-022-01730-5
pii: 10.1007/s12328-022-01730-5
doi:
Substances chimiques
Melanins
0
Biomarkers, Tumor
0
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
0
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
87-95Informations de copyright
© 2022. Japanese Society of Gastroenterology.
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