Human variation in population-wide gene expression data predicts gene perturbation phenotype.
Clinical genetics
Human genetics
Pathophysiology
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
18 Nov 2022
18 Nov 2022
Historique:
received:
02
03
2022
revised:
13
07
2022
accepted:
07
10
2022
entrez:
31
10
2022
pubmed:
1
11
2022
medline:
1
11
2022
Statut:
epublish
Résumé
Population-scale datasets of healthy individuals capture genetic and environmental factors influencing gene expression. The expression variance of a gene of interest (GOI) can be exploited to set up a quasi loss- or gain-of-function "
Identifiants
pubmed: 36310583
doi: 10.1016/j.isci.2022.105328
pii: S2589-0042(22)01600-5
pmc: PMC9614568
doi:
Types de publication
Journal Article
Langues
eng
Pagination
105328Informations de copyright
© 2022 The Authors.
Déclaration de conflit d'intérêts
The authors declare that they have no competing interests.
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