Macrophage infection, activation, and histopathological findings in ebolavirus infection.
filovirus
histology
human
immunity
liver
macaque
pathology
Journal
Frontiers in cellular and infection microbiology
ISSN: 2235-2988
Titre abrégé: Front Cell Infect Microbiol
Pays: Switzerland
ID NLM: 101585359
Informations de publication
Date de publication:
2022
2022
Historique:
received:
19
08
2022
accepted:
15
09
2022
entrez:
31
10
2022
pubmed:
1
11
2022
medline:
2
11
2022
Statut:
epublish
Résumé
Macrophages contribute to Ebola virus disease through their susceptibility to direct infection, their multi-faceted response to ebolaviruses, and their association with pathological findings in tissues throughout the body. Viral attachment and entry factors, as well as the more recently described influence of cell polarization, shape macrophage susceptibility to direct infection. Moreover, the study of Toll-like receptor 4 and the RIG-I-like receptor pathway in the macrophage response to ebolaviruses highlight important immune signaling pathways contributing to the breadth of macrophage responses. Lastly, the deep histopathological catalogue of macrophage involvement across numerous tissues during infection has been enriched by descriptions of tissues involved in sequelae following acute infection, including: the eye, joints, and the nervous system. Building upon this knowledge base, future opportunities include characterization of macrophage phenotypes beneficial or deleterious to survival, delineation of the specific roles macrophages play in pathological lesion development in affected tissues, and the creation of macrophage-specific therapeutics enhancing the beneficial activities and reducing the deleterious contributions of macrophages to the outcome of Ebola virus disease.
Identifiants
pubmed: 36310868
doi: 10.3389/fcimb.2022.1023557
pmc: PMC9597316
doi:
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1023557Subventions
Organisme : NIAID NIH HHS
ID : K99 AI156012
Pays : United States
Organisme : NCATS NIH HHS
ID : TL1 TR001440
Pays : United States
Informations de copyright
Copyright © 2022 Wanninger, Millian, Saldarriaga, Maruyama, Saito, Reyna, Taniguchi, Arroyave, Connolly, Stevenson and Paessler.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
J Immunol. 2003 Mar 15;170(6):2797-801
pubmed: 12626527
Arthritis Rheumatol. 2018 Oct;70(10):1533-1543
pubmed: 29790291
Clin Exp Immunol. 1988 Jun;72(3):510-5
pubmed: 3048809
Int J Exp Pathol. 1995 Aug;76(4):227-36
pubmed: 7547435
J Infect Dis. 1999 Feb;179 Suppl 1:S199-202
pubmed: 9988185
J Gen Virol. 2001 Jun;82(Pt 6):1365-1373
pubmed: 11369881
J Infect Dis. 2015 Oct 1;212 Suppl 2:S305-15
pubmed: 26038397
J Interferon Cytokine Res. 2014 Feb;34(2):79-89
pubmed: 24102579
PLoS Pathog. 2015 Nov 12;11(11):e1005263
pubmed: 26562011
PLoS One. 2013 Apr 23;8(4):e61904
pubmed: 23626748
Viruses. 2018 Sep 20;10(10):
pubmed: 30241284
J Infect Dis. 2018 Nov 22;218(suppl_5):S409-S417
pubmed: 30085162
Am J Pathol. 2022 Jan;192(1):121-129
pubmed: 34626576
J Virol. 2015 Oct 21;90(1):392-9
pubmed: 26491156
Viruses. 2021 Jul 17;13(7):
pubmed: 34372594
J Infect Dis. 2011 Nov;204 Suppl 3:S1011-20
pubmed: 21987737
Exp Anim. 2002 Oct;51(5):447-55
pubmed: 12451705
J Infect Dis. 2017 Dec 27;217(1):58-63
pubmed: 29087482
Lab Anim Sci. 1992 Apr;42(2):152-7
pubmed: 1318446
Sci Rep. 2018 Jan 19;8(1):1250
pubmed: 29352230
Proc Natl Acad Sci U S A. 2021 Jan 12;118(2):
pubmed: 33443221
J Virol. 2017 May 12;91(11):
pubmed: 28331091
Arch Pathol Lab Med. 1996 Feb;120(2):140-55
pubmed: 8712894
J Infect Dis. 2015 Oct 1;212 Suppl 2:S247-57
pubmed: 25877552
J Infect Dis. 2011 Nov;204 Suppl 3:S986-90
pubmed: 21987780
J Clin Virol. 2015 Mar;64:111-9
pubmed: 25660265
J Virol. 2013 Apr;87(7):3801-14
pubmed: 23345511
Cell Rep. 2020 Mar 24;30(12):4041-4051.e4
pubmed: 32209467
Virology. 2001 May 25;284(1):20-5
pubmed: 11352664
J Infect Dis. 2015 Oct 1;212 Suppl 2:S316-21
pubmed: 26185094
J Leukoc Biol. 2002 Oct;72(4):711-7
pubmed: 12377940
Hepatol Commun. 2019 Apr 22;3(6):730-743
pubmed: 31168508
PLoS Negl Trop Dis. 2011 Oct;5(10):e1359
pubmed: 22028943
Emerg Infect Dis. 2019 Feb;25(2):290-298
pubmed: 30666927
J Virol. 2013 Mar;87(6):3324-34
pubmed: 23302883
J Leukoc Biol. 2002 Mar;71(3):445-57
pubmed: 11867682
Mol Immunol. 2019 Aug;112:291-304
pubmed: 31228661
Clin Infect Dis. 1998 Aug;27(2):404-6
pubmed: 9709901
J Infect Dis. 2016 Oct 15;214(suppl 3):S308-S318
pubmed: 27601621
J Med Microbiol. 2012 Jan;61(Pt 1):8-15
pubmed: 21852521
J Leukoc Biol. 1994 Feb;55(2):259-61
pubmed: 7507970
Vet Pathol. 2013 May;50(3):514-29
pubmed: 23262834
Sci Rep. 2017 Aug 29;7(1):9730
pubmed: 28852031
PLoS Pathog. 2012;8(8):e1002847
pubmed: 22876185
Curr Top Microbiol Immunol. 1999;235:97-116
pubmed: 9893381
J Infect Dis. 2011 Nov;204 Suppl 3:S804-9
pubmed: 21987755
Nat Rev Dis Primers. 2020 Feb 20;6(1):13
pubmed: 32080199
Am J Pathol. 2020 Jul;190(7):1449-1460
pubmed: 32275904
J Infect Dis. 2017 Jan 1;215(1):64-69
pubmed: 27226206
Sci Rep. 2012;2:811
pubmed: 23155478
J Virol. 2016 May 12;90(11):5256-5269
pubmed: 26984723
J Infect Dis. 2015 Oct 1;212 Suppl 2:S282-94
pubmed: 25943199
J Comp Pathol. 2001 Nov;125(4):233-42
pubmed: 11798240
Int Rev Immunol. 2014 Jan;33(1):54-66
pubmed: 24156700
PLoS One. 2017 May 25;12(5):e0178224
pubmed: 28542463
PLoS Pathog. 2019 Oct 24;15(10):e1008068
pubmed: 31648236
J Cell Physiol. 2018 Sep;233(9):6425-6440
pubmed: 29319160
JCI Insight. 2019 Nov 1;4(21):
pubmed: 31550241
J Virol. 2001 Nov;75(22):11025-33
pubmed: 11602743
Bull World Health Organ. 1978;56(2):247-70
pubmed: 307455
J Infect Dis. 2011 Jul 15;204(2):200-8
pubmed: 21571728
Viruses. 2019 Sep 23;11(10):
pubmed: 31547585
J Comp Pathol. 1992 Feb;106(2):137-52
pubmed: 1597531
Cell Rep. 2017 Jan 17;18(3):816-829
pubmed: 28099857
J Infect Dis. 2015 Oct 1;212 Suppl 2:S242-6
pubmed: 25957965
Am J Pathol. 2020 Sep;190(9):1867-1880
pubmed: 32479821
Annu Rev Pathol. 2017 Jan 24;12:387-418
pubmed: 27959626
Nat Microbiol. 2017 Jul 17;2:17113
pubmed: 28715405
J Leukoc Biol. 2018 Oct;104(4):717-727
pubmed: 30095866
Cold Spring Harb Perspect Biol. 2012 Mar 01;4(3):
pubmed: 22296764
Viruses. 2015 Feb 03;7(2):511-21
pubmed: 25654239
J Infect Dis. 1999 Feb;179 Suppl 1:S54-9
pubmed: 9988165
Lancet. 2019 Mar 2;393(10174):936-948
pubmed: 30777297
Arch Pathol Lab Med. 2001 May;125(5):625-30
pubmed: 11300932
Virology. 2003 Jan 5;305(1):115-23
pubmed: 12504546
J Infect Dis. 2020 Oct 13;222(10):1745-1755
pubmed: 32498080
mBio. 2021 Aug 31;12(4):e0151721
pubmed: 34372693
Zoonoses Public Health. 2012 Sep;59 Suppl 2:116-31
pubmed: 22958256
J Infect Dis. 1998 Sep;178(3):651-61
pubmed: 9728532
Vet Pathol. 2015 Jan;52(1):21-5
pubmed: 24829285
Am J Pathol. 2003 Dec;163(6):2347-70
pubmed: 14633608
mBio. 2015 May 26;6(3):e00565-15
pubmed: 26015498
J Infect Dis. 2016 Jan 1;213(1):57-60
pubmed: 26153408
J Pathol. 2015 Jan;235(2):153-74
pubmed: 25297522
PLoS Negl Trop Dis. 2019 Dec 11;13(12):e0007819
pubmed: 31825972
J Infect Dis. 2011 Nov;204 Suppl 3:S973-7
pubmed: 21987778
Blood. 2007 Jun 15;109(12):5337-45
pubmed: 17339424
mBio. 2017 Apr 25;8(2):
pubmed: 28442605
Hepatology. 2009 Jan;49(1):287-96
pubmed: 19111020
Scand J Clin Lab Invest. 2012 Feb;72(1):1-13
pubmed: 22060747
Int J Mol Sci. 2020 Jul 31;21(15):
pubmed: 32752088
J Infect Dis. 2003 Dec 1;188(11):1618-29
pubmed: 14639531
J Infect Dis. 1999 Feb;179 Suppl 1:S203-17
pubmed: 9988186
J Infect Dis. 2016 Oct 15;214(suppl 3):S281-S289
pubmed: 27651412
J Infect Dis. 2016 Oct 15;214(suppl 3):S263-S267
pubmed: 27284090
J Leukoc Biol. 2021 Feb;109(2):309-325
pubmed: 32441445
Arch Virol. 1996;141(5):909-21
pubmed: 8678836