Targeted conditional collagen XII deletion alters tendon function.
Biomechanics
Col12a1
Collagen XII
Conditional mouse model
Tendon
Transgenic
Journal
Matrix biology plus
ISSN: 2590-0285
Titre abrégé: Matrix Biol Plus
Pays: Netherlands
ID NLM: 101775320
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
received:
15
07
2022
revised:
28
09
2022
accepted:
04
10
2022
entrez:
31
10
2022
pubmed:
1
11
2022
medline:
1
11
2022
Statut:
epublish
Résumé
Collagen XII is a fibril-associated collagen with interrupted triple helices (FACIT). This non-fibrillar collagen is a homotrimer composed of three α1(XII) chains assembled into a collagenous molecule with a C terminal collagenous domain and a large N terminal non-collagenous domain. During tendon development and growth, collagen XII is broadly expressed throughout the extracellular matrix and enriched pericellularly around tenocytes. Tendons in a global
Identifiants
pubmed: 36311462
doi: 10.1016/j.mbplus.2022.100123
pii: S2590-0285(22)00023-0
pmc: PMC9597098
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100123Subventions
Organisme : NIAMS NIH HHS
ID : R01 AR078790
Pays : United States
Informations de copyright
© 2022 Published by Elsevier B.V.
Déclaration de conflit d'intérêts
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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