Booster dose of mRNA vaccine augments waning T cell and antibody responses against SARS-CoV-2.

Humans SARS-CoV-2 Antibody Formation Viral Vaccines COVID-19 / prevention & control mRNA Vaccines
SARS-CoV-2 T cell response antibodies booster dose mRNA vaccine vector vaccine

Journal

Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960

Informations de publication

Date de publication:
2022
Historique:
received: 05 08 2022
accepted: 26 09 2022
entrez: 31 10 2022
pubmed: 1 11 2022
medline: 2 11 2022
Statut: epublish

Résumé

A gradual decay in humoral and cellular immune responses over time upon SAR1S-CoV-2 vaccination may cause a lack of protective immunity. We conducted a longitudinal analysis of antibodies, T cells, and monocytes in 25 participants vaccinated with mRNA or ChAdOx1-S up to 12 weeks after the 3

Identifiants

DOI: 10.3389/fimmu.2022.1012526 PMID: 36311732 PMC: PMC9597683
pubmed: 36311732
doi: 10.3389/fimmu.2022.1012526
pmc: PMC9597683
doi:

Substances chimiques

Viral Vaccines 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1012526

Informations de copyright

Copyright © 2022 Özbay Kurt, Lepper, Gerhards, Roemer, Lasser, Arkhypov, Bitsch, Bugert, Altevogt, Gouttefangeas, Neumaier, Utikal and Umansky.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Feyza Gül Özbay Kurt (FG)

Skin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karl University of Heidelberg, Mannheim, Germany.
DKFZ-Hector Cancer Institute, University Medical Center Mannheim, Mannheim, Germany.
Mannheim Institute for Innate Immunoscience (MI3), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.

Alisa Lepper (A)

Skin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karl University of Heidelberg, Mannheim, Germany.
DKFZ-Hector Cancer Institute, University Medical Center Mannheim, Mannheim, Germany.
Mannheim Institute for Innate Immunoscience (MI3), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.

Catharina Gerhards (C)

Institute for Clinical Chemistry, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.

Mathis Roemer (M)

Institute for Clinical Chemistry, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.

Samantha Lasser (S)

Skin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karl University of Heidelberg, Mannheim, Germany.
DKFZ-Hector Cancer Institute, University Medical Center Mannheim, Mannheim, Germany.
Mannheim Institute for Innate Immunoscience (MI3), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.

Ihor Arkhypov (I)

Skin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karl University of Heidelberg, Mannheim, Germany.
DKFZ-Hector Cancer Institute, University Medical Center Mannheim, Mannheim, Germany.
Mannheim Institute for Innate Immunoscience (MI3), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.

Rebekka Bitsch (R)

Skin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karl University of Heidelberg, Mannheim, Germany.
DKFZ-Hector Cancer Institute, University Medical Center Mannheim, Mannheim, Germany.
Mannheim Institute for Innate Immunoscience (MI3), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.

Peter Bugert (P)

German Red Cross Blood Service Baden-Württemberg - Hessen, Institute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

Peter Altevogt (P)

Skin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karl University of Heidelberg, Mannheim, Germany.
DKFZ-Hector Cancer Institute, University Medical Center Mannheim, Mannheim, Germany.
Mannheim Institute for Innate Immunoscience (MI3), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.

Cécile Gouttefangeas (C)

Department of Immunology, Institute for Cell Biology, University of Tübingen, Tübingen, Germany.

Michael Neumaier (M)

Institute for Clinical Chemistry, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.

Jochen Utikal (J)

Skin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karl University of Heidelberg, Mannheim, Germany.
DKFZ-Hector Cancer Institute, University Medical Center Mannheim, Mannheim, Germany.
Mannheim Institute for Innate Immunoscience (MI3), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.

Viktor Umansky (V)

Skin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karl University of Heidelberg, Mannheim, Germany.
DKFZ-Hector Cancer Institute, University Medical Center Mannheim, Mannheim, Germany.
Mannheim Institute for Innate Immunoscience (MI3), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.

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