Altered mannose metabolism in chronic stress and depression is rapidly reversed by vitamin B12.
depression
glycosylation
mannose
stress
vitamin B12
Journal
Frontiers in nutrition
ISSN: 2296-861X
Titre abrégé: Front Nutr
Pays: Switzerland
ID NLM: 101642264
Informations de publication
Date de publication:
2022
2022
Historique:
received:
29
06
2022
accepted:
15
09
2022
entrez:
31
10
2022
pubmed:
1
11
2022
medline:
1
11
2022
Statut:
epublish
Résumé
GDP-Mannose Pyrophosphorylase B (GMPPB) is a key enzyme for glycosylation. Previous studies suggested a dysregulation of GMPBB and mannose in depression. Evidence, however, was sporadic and interventions to reverse these changes are unknown. Here, we show that GMPPB protein, but not RNA abundance is increased in the postmortem prefrontal cortex (PFC) of depressed patients and the chronic variable stress (CVS) mouse-model. This is accompanied by higher plasma mannose levels. Importantly, a single dose of intraperitoneally administered vitamin B12, which has previously been shown to rapidly reverse behavioral symptoms and molecular signatures of chronic stress in mice, normalized GMPPB plasma mannose levels and elevated GDP-mannose abundance. In summary, these data underline metabolic dysregulation in chronic stress and depression and provide further support for rapid effects of vitamin B12 on chronic stress.
Identifiants
pubmed: 36313076
doi: 10.3389/fnut.2022.981511
pmc: PMC9609420
doi:
Types de publication
Journal Article
Langues
eng
Pagination
981511Informations de copyright
Copyright © 2022 Franzka, Turecki, Cubillos, Kentache, Steiner, Walter, Hübner and Engmann.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Biol Psychiatry. 2017 Dec 1;82(11):794-805
pubmed: 28577753
Front Mol Neurosci. 2018 Jun 04;11:188
pubmed: 29915530
J Inherit Metab Dis. 2016 Sep;39(5):713-723
pubmed: 27287710
Neuropharmacology. 2020 Jul;171:108112
pubmed: 32335151
Open Neurol J. 2013 Nov 15;7:44-8
pubmed: 24339839
J Clin Invest. 2021 May 3;131(9):
pubmed: 33755596
Neuroreport. 2013 Aug 21;24(12):688-91
pubmed: 23820740
Transl Psychiatry. 2021 Feb 2;11(1):90
pubmed: 33531473
J Nutr. 2012 Aug;142(8):1554-60
pubmed: 22739363
Neuropharmacology. 2020 Aug 1;172:108133
pubmed: 32413367
Front Psychiatry. 2022 Mar 15;13:815211
pubmed: 35370823
Eur J Biochem. 2000 Dec;267(23):6866-74
pubmed: 11082198
Curr Biol. 2017 Nov 6;27(21):R1147-R1151
pubmed: 29112863
J Neurochem. 2016 Aug;138(4):546-56
pubmed: 27216994
PLoS One. 2010 Oct 29;5(10):e13743
pubmed: 21060795
J Cell Sci. 2006 Oct 15;119(Pt 20):4276-84
pubmed: 17003106
Biol Psychiatry. 2020 Jul 15;88(2):159-168
pubmed: 32169281
Sci Signal. 2016 Aug 30;9(443):rs9
pubmed: 27577262
Front Mol Biosci. 2021 May 28;8:673044
pubmed: 34124155
Am J Psychiatry. 2000 May;157(5):715-21
pubmed: 10784463
Am J Hum Genet. 2013 Jul 11;93(1):29-41
pubmed: 23768512
Nat Methods. 2014 Jun;11(6):629-32
pubmed: 24776635
Nat Med. 2017 Sep;23(9):1102-1111
pubmed: 28825715
J Biol Chem. 2011 Mar 25;286(12):10193-200
pubmed: 21273394
Biochem Pharmacol. 2004 Nov 1;68(9):1787-96
pubmed: 15450944
Mol Biomed. 2021 May 10;2(1):13
pubmed: 35006422
Nat Struct Mol Biol. 2021 May;28(5):1-12
pubmed: 33986552
Am J Psychiatry. 2002 Dec;159(12):2099-101
pubmed: 12450964
Ann Neurol. 2010 Oct;68(4):503-10
pubmed: 20976769
Nat Neurosci. 2021 Jun;24(6):810-817
pubmed: 33846625
Am J Hum Genet. 2013 Oct 3;93(4):727-34
pubmed: 24035193
Pediatr Clin North Am. 2018 Apr;65(2):375-388
pubmed: 29502919
Biochem Biophys Res Commun. 2014 Oct 17;453(2):220-8
pubmed: 24931670