Acceptance and Perception of Artificial Intelligence Usability in Eye Care (APPRAISE) for Ophthalmologists: A Multinational Perspective.

artificial intelligence (AI) implementation ophthalmology regulation translation

Journal

Frontiers in medicine
ISSN: 2296-858X
Titre abrégé: Front Med (Lausanne)
Pays: Switzerland
ID NLM: 101648047

Informations de publication

Date de publication:
2022
Historique:
received: 14 02 2022
accepted: 29 03 2022
entrez: 31 10 2022
pubmed: 1 11 2022
medline: 1 11 2022
Statut: epublish

Résumé

Many artificial intelligence (AI) studies have focused on development of AI models, novel techniques, and reporting guidelines. However, little is understood about clinicians' perspectives of AI applications in medical fields including ophthalmology, particularly in light of recent regulatory guidelines. The aim for this study was to evaluate the perspectives of ophthalmologists regarding AI in 4 major eye conditions: diabetic retinopathy (DR), glaucoma, age-related macular degeneration (AMD) and cataract. This was a multi-national survey of ophthalmologists between March 1st, 2020 to February 29th, 2021 disseminated One thousand one hundred seventy-six ophthalmologists from 70 countries participated with a response rate ranging from 78.8 to 85.8% per question. Ophthalmologists were more willing to use AI as clinical assistive tools (88.1%, Ophthalmologists are receptive to adopting AI as assistive tools for DR, glaucoma, and AMD. Furthermore, ML is a useful method that can be applied to evaluate predictive factors on clinical qualitative questionnaires. This study outlines actionable insights for future research and facilitation interventions to drive adoption and operationalization of AI tools for Ophthalmology.

Sections du résumé

Background UNASSIGNED
Many artificial intelligence (AI) studies have focused on development of AI models, novel techniques, and reporting guidelines. However, little is understood about clinicians' perspectives of AI applications in medical fields including ophthalmology, particularly in light of recent regulatory guidelines. The aim for this study was to evaluate the perspectives of ophthalmologists regarding AI in 4 major eye conditions: diabetic retinopathy (DR), glaucoma, age-related macular degeneration (AMD) and cataract.
Methods UNASSIGNED
This was a multi-national survey of ophthalmologists between March 1st, 2020 to February 29th, 2021 disseminated
Results UNASSIGNED
One thousand one hundred seventy-six ophthalmologists from 70 countries participated with a response rate ranging from 78.8 to 85.8% per question. Ophthalmologists were more willing to use AI as clinical assistive tools (88.1%,
Conclusion UNASSIGNED
Ophthalmologists are receptive to adopting AI as assistive tools for DR, glaucoma, and AMD. Furthermore, ML is a useful method that can be applied to evaluate predictive factors on clinical qualitative questionnaires. This study outlines actionable insights for future research and facilitation interventions to drive adoption and operationalization of AI tools for Ophthalmology.

Identifiants

pubmed: 36314006
doi: 10.3389/fmed.2022.875242
pmc: PMC9612721
doi:

Types de publication

Journal Article

Langues

eng

Pagination

875242

Subventions

Organisme : Medical Research Council
ID : MR/T019050/1
Pays : United Kingdom

Informations de copyright

Copyright © 2022 Gunasekeran, Zheng, Lim, Chong, Zhang, Ng, Keel, Xiang, Park, Park, Chandra, Wu, Campbel, Lee, Keane, Denniston, Lam, Fung, Chan, Sadda, Loewenstein, Grzybowski, Fong, Wu, Bachmann, Zhang, Yam, Cheung, Pongsachareonnont, Ruamviboonsuk, Raman, Sakamoto, Habash, Girard, Milea, Ang, Tan, Schmetterer, Cheng, Lamoureux, Lin, van Wijngaarden, Wong and Ting.

Déclaration de conflit d'intérêts

DG reports appointment as Physician Leader (Telemedicine) for Raffles Medical Group (SGX:$BSL.SI) and investments in digital health start-ups AskDr, Doctorbell (acquired by MaNaDr), Shyfts, and VISRE. JC reports appointment as a consultant to Boston AI labs. AYL reports grants from Santen, personal fees from Genentech, US FDA, Johnson and Johnson, grants from Carl Zeiss Meditec, personal fees from Topcon, Gyroscope, non-financial support from Microsoft, grants from Regeneron, outside the submitted work; This article does not reflect the views of the US FDA. PK reports having acted as a consultant for DeepMind, Roche, Novartis, Apellis, and BitFount and is an equity owner in Big Picture Medical. He has received speaker fees from Heidelberg Engineering, Topcon, Allergan, and Bayer. AF reports honoraria, advisory board and grant funding from Alcon, Bayer, Novartis, Allergan, Roche, and Syneos Health. AL reports grants from Roche and Novartis, and appointment as a consultant to NotalVision, Allergan, Bayer, WebMD, and Beyeonics. AG reports appointment to provide lectures for Pfizer, Thea, and Polpharma. TS reports appointment as a consultant & advisory board for Bayer Yakuhin, Boehringer-Ingelheim, Novartis, Chugai, Senju, and Santen. DM reports funding support from the Singapore National Medical Research Council (NMRC-CIRG18Nov-0013), and the Duke-NUS Medical School, Singapore (ACP 05/FY2019/P2/06-A60). DM also reports appointment as consultant and Advisory Board Member of Optomed, Finland. TW reports appointment as the deputy group chief executive officer (research and education) of Singapore Health Services, a consultant & advisory board for Allergan, Bayer, Boehringer-Ingelheim, Genentech, Merck, Novartis, Oxurion (formerly ThromboGenics), Roche, and co-founder of Plano. DT reports funding from the following grants for research about AI in healthcare: National Medical Research Council, Singapore (NMRC/HSRG/0087/2018; MOH-000655-00), National Health Innovation Center, Singapore (NHIC-COV19-2005017), SingHealth Fund Limited Foundation (SHF/HSR113/2017), Duke-NUS Medical School, Singapore (Duke-NUS/RSF/2021/0018; 05/FY2020/EX/15-A58), and Agency for Science, Technology and Research (ASTAR), Singapore (A20H4g2141 and A20H4g2141). DT, GL, and TW also report being the co-inventors of a deep learning system for retinal diseases and co-founders of related start-up Eyris; potential conflicts of interests are managed according to institutional policies of the Singapore Health System (SingHealth) and the National University of Singapore (NUS). The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Références

BMJ. 2020 Mar 20;368:l6927
pubmed: 32198138
Nat Med. 2020 Apr;26(4):459-461
pubmed: 32284618
Sci Rep. 2019 Sep 16;9(1):13298
pubmed: 31527630
Asia Pac J Ophthalmol (Phila). 2020 Jul-Aug;9(4):299-307
pubmed: 32694344
Br J Ophthalmol. 2022 Apr;106(4):452-457
pubmed: 33753407
Lancet Digit Health. 2021 Feb;3(2):e124-e134
pubmed: 33509383
Br J Ophthalmol. 2019 Nov;103(11):1537-1538
pubmed: 31481391
Nat Med. 2019 Jan;25(1):30-36
pubmed: 30617336
BMJ. 2020 Mar 12;368:m998
pubmed: 32165352
J Biomed Inform. 2010 Feb;43(1):159-72
pubmed: 19615467
N Engl J Med. 2020 Apr 30;382(18):1687-1695
pubmed: 32286748
JAMA. 2016 Dec 13;316(22):2366-2367
pubmed: 27898977
Ann Intern Med. 1989 Jun 1;110(11):893-900
pubmed: 2655522
Ophthalmology. 2018 Oct;125(10):1608-1622
pubmed: 29776671
Sci Rep. 2021 Mar 4;11(1):5193
pubmed: 33664367
Insights Imaging. 2019 Oct 31;10(1):105
pubmed: 31673823
Lancet. 2019 Apr 20;393(10181):1577-1579
pubmed: 31007185
NPJ Digit Med. 2021 Feb 26;4(1):40
pubmed: 33637833
AMIA Annu Symp Proc. 2018 Dec 05;2018:490-497
pubmed: 30815089
Nat Med. 2018 May;24(5):539-540
pubmed: 29736024
Nat Med. 2021 Feb;27(2):186-187
pubmed: 33526932
BMC Med Inform Decis Mak. 2020 Nov 30;20(1):310
pubmed: 33256715
World J Emerg Med. 2020;11(1):5-11
pubmed: 31892997
Future Healthc J. 2019 Jun;6(2):94-98
pubmed: 31363513
Asia Pac J Ophthalmol (Phila). 2019 Nov-Dec;8(6):424-428
pubmed: 31789642
Front Psychiatry. 2020 Sep 09;11:582007
pubmed: 33033487
Br J Ophthalmol. 2020 Mar;104(3):299-300
pubmed: 31796427
Nat Med. 2020 Jun;26(6):807-808
pubmed: 32514173
Am J Ophthalmol. 2020 Jun;214:134-142
pubmed: 32171769
Lancet Diabetes Endocrinol. 2018 Feb;6(2):91
pubmed: 29413164
Asia Pac J Ophthalmol (Phila). 2020 Mar-Apr;9(2):78-84
pubmed: 32349114
Artif Intell Med. 2020 Jan;102:101780
pubmed: 31980086
Br J Ophthalmol. 2012 Jun;96(6):783-7
pubmed: 22452836
Asia Pac J Ophthalmol (Phila). 2020 Mar-Apr;9(2):61-66
pubmed: 32349112
Lancet Digit Health. 2020 Oct;2(10):e537-e548
pubmed: 33328048
Front Big Data. 2021 Jun 01;4:623794
pubmed: 34142082
Insights Imaging. 2020 Feb 5;11(1):14
pubmed: 32025951
J AAPOS. 2014 Dec;18(6):584-9
pubmed: 25456030
N Engl J Med. 1982 May 27;306(21):1263-8
pubmed: 7070446
BMC Bioinformatics. 2018 Jul 17;19(1):270
pubmed: 30016950
JAMA Ophthalmol. 2019 Sep 01;137(9):987-993
pubmed: 31194246
NPJ Digit Med. 2019 Apr 26;2:28
pubmed: 31304375
Lancet Glob Health. 2021 Feb;9(2):e144-e160
pubmed: 33275949
Lancet Digit Health. 2020 Oct;2(10):e549-e560
pubmed: 33328049
Lancet Digit Health. 2020 May;2(5):e240-e249
pubmed: 33328056
Lancet Glob Health. 2017 Sep;5(9):e888-e897
pubmed: 28779882
Curr Opin Ophthalmol. 2020 Sep;31(5):357-365
pubmed: 32740069
Prog Retin Eye Res. 2021 May;82:100900
pubmed: 32898686

Auteurs

Dinesh V Gunasekeran (DV)

Singapore Eye Research Institute (SERI), Singapore National Eye Center (SNEC), Singapore, Singapore.
School of Medicine, National University of Singapore (NUS), Singapore, Singapore.
Duke-NUS Medical School, Singapore, Singapore.

Feihui Zheng (F)

Singapore Eye Research Institute (SERI), Singapore National Eye Center (SNEC), Singapore, Singapore.

Gilbert Y S Lim (GYS)

Singapore Eye Research Institute (SERI), Singapore National Eye Center (SNEC), Singapore, Singapore.
Duke-NUS Medical School, Singapore, Singapore.

Crystal C Y Chong (CCY)

Singapore Eye Research Institute (SERI), Singapore National Eye Center (SNEC), Singapore, Singapore.

Shihao Zhang (S)

Singapore Eye Research Institute (SERI), Singapore National Eye Center (SNEC), Singapore, Singapore.

Wei Yan Ng (WY)

Singapore Eye Research Institute (SERI), Singapore National Eye Center (SNEC), Singapore, Singapore.

Stuart Keel (S)

Department of Ophthalmology, University of Melbourne, Melbourne, VIC, Australia.

Yifan Xiang (Y)

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center (ZOC), Sun Yat-sen University, Guangzhou, China.

Ki Ho Park (KH)

Department of Ophthalmology, Seoul National University College of Medicine, Seoul, South Korea.

Sang Jun Park (SJ)

Department of Ophthalmology, Seoul National University College of Medicine, Seoul, South Korea.
Department of Ophthalmology, Seoul National University Bundang Hospital, Seongnam-si, South Korea.

Aman Chandra (A)

Department of Ophthalmology, Southend University Hospital, Southend-on-Sea, United Kingdom.

Lihteh Wu (L)

Asociados de Macula, Vitreo y Retina de Costa Rica, San José, Costa Rica.

J Peter Campbel (JP)

Casey Eye Institute, Oregon Health and Science, Portland, OR, United States.

Aaron Y Lee (AY)

Department of Ophthalmology, University of Washington, Seattle, WA, United States.

Pearse A Keane (PA)

Moorfields Eye Hospital, London, United Kingdom.

Alastair Denniston (A)

Department of Ophthalmology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom.
Institute of Ophthalmology, University College London (UCL), London, United Kingdom.

Dennis S C Lam (DSC)

International Eye Research Institute of the Chinese University of Hong Kong (Shenzhen), Shenzhen, China.
C-MER International Eye Research Center of the Chinese University of Hong Kong (Shenzhen), Shenzhen, China.

Adrian T Fung (AT)

Specialty of Clinical Ophthalmology and Eye Health, Faculty of Medicine and Health, Westmead Clinical School, The University of Sydney, Sydney, NSW, Australia.
Department of Ophthalmology, Faculty of Medicine, Health and Human Sciences, Macquarie University Hospital, Sydney, NSW, Australia.

Paul R V Chan (PRV)

Department of Ophthalmology, University of Illinois College of Medicine, Chicago, IL, United States.

SriniVas R Sadda (SR)

Department of Ophthalmology, Doheny Eye Institute, Los Angeles, CA, United States.

Anat Loewenstein (A)

Department of Ophthalmology, Tel Aviv Medical Center, Tel Aviv, Israel.

Andrzej Grzybowski (A)

Department of Ophthalmology, University of Warmia and Mazury, Olsztyn, Poland.
Institute for Research in Ophthalmology, Ponzan, Poland.

Kenneth C S Fong (KCS)

OasisEye Specialists, Kuala Lumpur, Malaysia.

Wei-Chi Wu (WC)

Department of Ophthalmology, Chang Gung Memorial Hospital, Taoyuan, Taiwan.

Lucas M Bachmann (LM)

Oculocare Medical AG, Zurich, Switzerland.

Xiulan Zhang (X)

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center (ZOC), Sun Yat-sen University, Guangzhou, China.

Jason C Yam (JC)

Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong (CUHK), Hong Kong, Hong Kong SAR, China.

Carol Y Cheung (CY)

Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong (CUHK), Hong Kong, Hong Kong SAR, China.

Pear Pongsachareonnont (P)

Vitreoretinal Research Unit, Department of Ophthalmology, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Bangkok, Thailand.

Paisan Ruamviboonsuk (P)

Department of Ophthalmology, College of Medicine, Rangsit University, Rajavithi Hospital, Bangkok, Thailand.

Rajiv Raman (R)

Vitreo-Retinal Department, Sankara Nethralaya, Chennai, India.

Taiji Sakamoto (T)

Department of Ophthalmology, Kagoshima University, Kagoshima, Japan.

Ranya Habash (R)

Bascom Palmar Eye Institute, Miami, FL, United States.

Michael Girard (M)

Singapore Eye Research Institute (SERI), Singapore National Eye Center (SNEC), Singapore, Singapore.
Duke-NUS Medical School, Singapore, Singapore.

Dan Milea (D)

Singapore Eye Research Institute (SERI), Singapore National Eye Center (SNEC), Singapore, Singapore.
Copenhagen University Hospital, Copenhagen, Denmark.

Marcus Ang (M)

Singapore Eye Research Institute (SERI), Singapore National Eye Center (SNEC), Singapore, Singapore.
School of Medicine, National University of Singapore (NUS), Singapore, Singapore.
Duke-NUS Medical School, Singapore, Singapore.

Gavin S W Tan (GSW)

Singapore Eye Research Institute (SERI), Singapore National Eye Center (SNEC), Singapore, Singapore.
School of Medicine, National University of Singapore (NUS), Singapore, Singapore.
Duke-NUS Medical School, Singapore, Singapore.

Leopold Schmetterer (L)

Singapore Eye Research Institute (SERI), Singapore National Eye Center (SNEC), Singapore, Singapore.
School of Medicine, National University of Singapore (NUS), Singapore, Singapore.
Duke-NUS Medical School, Singapore, Singapore.

Ching-Yu Cheng (CY)

Singapore Eye Research Institute (SERI), Singapore National Eye Center (SNEC), Singapore, Singapore.
School of Medicine, National University of Singapore (NUS), Singapore, Singapore.
Duke-NUS Medical School, Singapore, Singapore.

Ecosse Lamoureux (E)

Singapore Eye Research Institute (SERI), Singapore National Eye Center (SNEC), Singapore, Singapore.
School of Medicine, National University of Singapore (NUS), Singapore, Singapore.
Duke-NUS Medical School, Singapore, Singapore.

Haotian Lin (H)

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center (ZOC), Sun Yat-sen University, Guangzhou, China.

Peter van Wijngaarden (P)

Department of Ophthalmology, University of Melbourne, Melbourne, VIC, Australia.

Tien Y Wong (TY)

Singapore Eye Research Institute (SERI), Singapore National Eye Center (SNEC), Singapore, Singapore.
School of Medicine, National University of Singapore (NUS), Singapore, Singapore.
Duke-NUS Medical School, Singapore, Singapore.
Tsinghua Medicine, Tsinghua University, Beijing, China.

Daniel S W Ting (DSW)

Singapore Eye Research Institute (SERI), Singapore National Eye Center (SNEC), Singapore, Singapore.
School of Medicine, National University of Singapore (NUS), Singapore, Singapore.
Duke-NUS Medical School, Singapore, Singapore.

Classifications MeSH