Weight management in young adults with type 1 diabetes: The advancing care for type 1 diabetes and obesity network sequential multiple assignment randomized trial pilot results.
Mediterranean diet
adaptive designs
glycaemia
low carbohydrate diet
obesity
type 1 diabetes
weight management
Journal
Diabetes, obesity & metabolism
ISSN: 1463-1326
Titre abrégé: Diabetes Obes Metab
Pays: England
ID NLM: 100883645
Informations de publication
Date de publication:
03 2023
03 2023
Historique:
revised:
22
10
2022
received:
08
07
2022
accepted:
28
10
2022
pmc-release:
01
03
2024
pubmed:
1
11
2022
medline:
4
2
2023
entrez:
31
10
2022
Statut:
ppublish
Résumé
Co-management of weight and glycaemia is critical yet challenging in type 1 diabetes (T1D). We evaluated the effect of a hypocaloric low carbohydrate, hypocaloric moderate low fat, and Mediterranean diet without calorie restriction on weight and glycaemia in young adults with T1D and overweight or obesity. We implemented a 9-month Sequential, Multiple Assignment, Randomized Trial pilot among adults aged 19-30 years with T1D for ≥1 year and body mass index 27-39.9 kg/m Adjusted weight and HbA1c (n = 38) changed by -2.7 kg (95% CI -3.8, -1.5, P < .0001) and -0.91 percentage points (95% CI -1.5, -0.30, P = .005), respectively, while adjusted body fat percentage remained stable, on average (P = .21). Hypoglycaemia indices remained unchanged following adjustment (n = 28, P > .05). Variability in all outcomes, including weight change, was considerable (57.9% were re-randomized primarily due to loss of <2% body weight). No outcomes varied by diet. Three months of a diet, irrespective of macronutrient distribution or caloric restriction, resulted in weight loss while improving or maintaining HbA1c levels without increasing hypoglycaemia in adults with T1D.
Identifiants
pubmed: 36314293
doi: 10.1111/dom.14911
pmc: PMC9898100
mid: NIHMS1846080
doi:
Substances chimiques
Glycated Hemoglobin
0
Types de publication
Randomized Controlled Trial
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
688-699Subventions
Organisme : NIDDK NIH HHS
ID : DP3 DK113358
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK056350
Pays : United States
Informations de copyright
© 2022 John Wiley & Sons Ltd.
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