What's Old and New in Tuberculosis Vaccines for Children.


Journal

Journal of the Pediatric Infectious Diseases Society
ISSN: 2048-7207
Titre abrégé: J Pediatric Infect Dis Soc
Pays: England
ID NLM: 101586049

Informations de publication

Date de publication:
31 Oct 2022
Historique:
entrez: 31 10 2022
pubmed: 1 11 2022
medline: 2 11 2022
Statut: ppublish

Résumé

Tuberculosis (TB) is a leading cause of global child mortality. Until the turn of the 21st century, Mycobacterium bovis bacille Calmette-Guerin (BCG) was the only vaccine to prevent TB. The pediatric TB vaccine pipeline has advanced in the past decade to include the evaluation of novel whole cell vaccines to replace infant BCG and investigation of subunit and whole cell vaccines to boost TB immunity during adolescence. We describe the history of BCG, current TB vaccine candidates in clinical trials, and the challenges and opportunities for future TB vaccine research in children. Children are a critical target population for TB vaccines, and expansion of the pediatric TB vaccine pipeline is urgently needed to end the TB pandemic.

Identifiants

pubmed: 36314550
pii: 6775666
doi: 10.1093/jpids/piac078
pmc: PMC9620432
doi:

Substances chimiques

Tuberculosis Vaccines 0
BCG Vaccine 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

S110-S116

Subventions

Organisme : NIAID NIH HHS
ID : K23 AI143479
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002378
Pays : United States
Organisme : NIH HHS
ID : K23AI143479
Pays : United States

Informations de copyright

© The Author(s) 2022. Published by Oxford University Press on behalf of The Journal of the Pediatric Infectious Diseases Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

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Auteurs

Lisa M Cranmer (LM)

Department of Pediatrics, Division of Pediatric Infectious Disease, Emory School of Medicine, Atlanta, Georgia, USA.
Department of Epidemiology, Emory Rollins School of Public Health, Atlanta, Georgia, USA.
Children's Healthcare of Atlanta, Atlanta, Georgia, USA.

Mark F Cotton (MF)

Department of Pediatrics and Child Health, Stellenbosch University, Tygerberg, South Africa.

Cheryl L Day (CL)

Department of Microbiology & Immunology, Emory School of Medicine, Atlanta, Georgia, USA.
Emory Vaccine Center, Atlanta, Georgia, USA.

Elisa Nemes (E)

South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine, Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa.

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