Drug Repurposing in Chagas Disease: Chloroquine Potentiates Benznidazole Activity against Trypanosoma cruzi

Mice Animals Trypanosoma cruzi Drug Repositioning Chloroquine / pharmacology Chagas Disease / drug therapy Nitroimidazoles / pharmacology Trypanocidal Agents / pharmacology
Chagas disease drug discovery benznidazole chloroquine drug combination drug repurposing

Journal

Antimicrobial agents and chemotherapy
ISSN: 1098-6596
Titre abrégé: Antimicrob Agents Chemother
Pays: United States
ID NLM: 0315061

Informations de publication

Date de publication:
15 11 2022
Historique:
pubmed: 1 11 2022
medline: 18 11 2022
entrez: 31 10 2022
Statut: ppublish

Résumé

Drug combinations and drug repurposing have emerged as promising strategies to develop novel treatments for infectious diseases, including Chagas disease. In this study, we aimed to investigate whether the repurposed drugs chloroquine (CQ) and colchicine (COL), known to inhibit Trypanosoma cruzi infection in host cells, could boost the anti-T. cruzi effect of the trypanocidal drug benznidazole (BZN), increasing its therapeutic efficacy while reducing the dose needed to eradicate the parasite. The combination of BZN and COL exhibited cytotoxicity to infected cells and low antiparasitic activity. Conversely, a combination of BZN and CQ significantly reduced T. cruzi infection

Identifiants

DOI: 10.1128/aac.00284-22 PMID: 36314800 PMC: PMC9664849
pubmed: 36314800
doi: 10.1128/aac.00284-22
pmc: PMC9664849
doi:

Substances chimiques

benzonidazole YC42NRJ1ZD
Chloroquine 886U3H6UFF
Nitroimidazoles 0
Trypanocidal Agents 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e0028422

Références

Comput Struct Biotechnol J. 2016 Dec 14;15:98-103
pubmed: 28066534
Am J Trop Med Hyg. 2017 Nov;97(5):1289-1303
pubmed: 29016289
Am J Physiol. 1998 Apr;274(4):R1058-64
pubmed: 9575969
PLoS One. 2017 Sep 25;12(9):e0184922
pubmed: 28945807
Sci Rep. 2014 Apr 16;4:4703
pubmed: 24736467
Viruses. 2014 Feb 10;6(2):683-708
pubmed: 24517970
Ann Trop Med Parasitol. 2008 Sep;102(6):481-7
pubmed: 18782487
Lancet Infect Dis. 2018 Apr;18(4):419-430
pubmed: 29352704
Antimicrob Agents Chemother. 2011 Aug;55(8):3899-907
pubmed: 21646487
Sci Rep. 2017 Dec 21;7(1):17990
pubmed: 29269773
Curr Opin Infect Dis. 2006 Dec;19(6):583-7
pubmed: 17075335
Expert Rev Clin Pharmacol. 2018 Oct;11(10):943-957
pubmed: 30111183
Antimicrob Agents Chemother. 2016 Jun 20;60(7):4297-309
pubmed: 27161638
Trans R Soc Trop Med Hyg. 1987;81(5):755-9
pubmed: 3130683
Antimicrob Agents Chemother. 2004 Nov;48(11):4097-102
pubmed: 15504827
Semin Arthritis Rheum. 2015 Dec;45(3):341-50
pubmed: 26228647
PLoS Negl Trop Dis. 2018 Jul 12;12(7):e0006612
pubmed: 30001347
Stem Cells Int. 2021 Aug 11;2021:2642807
pubmed: 34434238
Elife. 2018 Mar 26;7:
pubmed: 29578409
Nat Rev Microbiol. 2017 Feb 27;15(4):217-231
pubmed: 28239154
Cell Rep Med. 2021 Oct 19;2(10):100423
pubmed: 34693368
J Antimicrob Chemother. 2003 Jul;52(1):1
pubmed: 12805255
Curr Opin Immunol. 2020 Oct;66:98-107
pubmed: 32823144
Antimicrob Agents Chemother. 2020 Aug 20;64(9):
pubmed: 32571827
Nat Rev Drug Discov. 2018 Jan;17(1):35-56
pubmed: 28935918
J Immunol Methods. 1983 Dec 16;65(1-2):55-63
pubmed: 6606682
Nat Rev Rheumatol. 2020 Mar;16(3):155-166
pubmed: 32034323
Mem Inst Oswaldo Cruz. 2010 Mar;105(2):233-8
pubmed: 20428688
Acta Trop. 2012 Sep;123(3):170-7
pubmed: 22609548
J Immunol. 2011 Apr 15;186(8):4794-804
pubmed: 21398612
Lancet Infect Dis. 2021 Aug;21(8):1129-1140
pubmed: 33836161
Int J Antimicrob Agents. 2004 Jun;23(6):634-6
pubmed: 15194137
N Engl J Med. 2014 May 15;370(20):1899-908
pubmed: 24827034
Mem Inst Oswaldo Cruz. 2003 Oct;98(7):953-8
pubmed: 14762524
Sci STKE. 2005 Jul 19;2005(293):pe36
pubmed: 16030288
Front Public Health. 2019 Jul 02;7:166
pubmed: 31312626
Int J Parasitol Drugs Drug Resist. 2016 Dec;6(3):165-170
pubmed: 27639944
J Cell Biol. 1996 Jul;134(2):349-62
pubmed: 8707821
Acta Trop. 2019 Oct;198:105107
pubmed: 31351074
J Antimicrob Chemother. 2009 Dec;64(6):1139-47
pubmed: 19819909
J Am Coll Cardiol. 2017 Feb 28;69(8):939-947
pubmed: 28231946
Trop Med Infect Dis. 2019 May 17;4(2):
pubmed: 31108888
Int J Parasitol. 2002 Jun 15;32(7):889-96
pubmed: 12062560
Infect Immun. 2011 May;79(5):1855-62
pubmed: 21343357
Reprod Health. 2020 Aug 24;17(1):128
pubmed: 32831069
Trials. 2020 Apr 15;21(1):328
pubmed: 32293523
Rheumatology (Oxford). 2006 Jun;45(6):703-10
pubmed: 16418198
Antimicrob Agents Chemother. 2010 Aug;54(8):3326-34
pubmed: 20547819
Int J Parasitol Drugs Drug Resist. 2018 Dec;8(3):430-439
pubmed: 30293058
J Exp Med. 1990 Feb 1;171(2):401-13
pubmed: 2406362
An Acad Bras Cienc. 2006 Mar;78(1):87-111
pubmed: 16532210
J Infect Dis. 2014 Mar 1;209(5):754-63
pubmed: 24133190
Mem Inst Oswaldo Cruz. 2014 Sep;109(6):828-33
pubmed: 25317712
Antimicrob Agents Chemother. 2018 May 25;62(6):
pubmed: 29555633
ACS Infect Dis. 2018 Feb 9;4(2):88-92
pubmed: 29298032
Antimicrob Agents Chemother. 2005 Apr;49(4):1521-8
pubmed: 15793134
Evid Based Complement Alternat Med. 2016;2016:1523691
pubmed: 26941821
N Engl J Med. 2015 Oct;373(14):1295-306
pubmed: 26323937
Autophagy. 2018;14(8):1435-1455
pubmed: 29940786
Lancet Infect Dis. 2013 Apr;13(4):342-8
pubmed: 23395248
Int J Cell Biol. 2010;2010:
pubmed: 20811486
Arq Bras Cardiol. 2011 Dec;97(6):517-25
pubmed: 22030565

Auteurs

Ramendra P Pandey (RP)

Laboratory of Immunology, Heart Institute, School of Medicine, University of São Paulo, São Paulo, Brazil.
School of Medicine, University of São Paulo, São Paulo, Brazil.

Marilda Savoia Nascimento (MS)

School of Medicine, University of São Paulo, São Paulo, Brazil.
Institute of Tropical Medicine of São Paulo, São Paulo, Brazil.

Caio Haddad Franco (CH)

Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.

Karina Bortoluci (K)

Department of Pharmacology, Federal University of São Paulo, São Paulo, Brazil.

Marcelo Nunes Silva (MN)

Department of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, Brazil.

Bianca Zingales (B)

Department of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, Brazil.

Daniel Gibaldi (D)

Institute Oswaldo Cruz-Fiocruz, Rio de Janeiro, Brazil.

Leda Castaño Barrios (L)

Institute Oswaldo Cruz-Fiocruz, Rio de Janeiro, Brazil.

Joseli Lannes-Vieira (J)

Institute Oswaldo Cruz-Fiocruz, Rio de Janeiro, Brazil.

Leonardo Moro Cariste (LM)

Recombinant Vaccines Laboratory, Department of Biosciences, Federal University of São Paulo, São Paulo, Brazil.

Jose Ronnie Vasconcelos (JR)

Recombinant Vaccines Laboratory, Department of Biosciences, Federal University of São Paulo, São Paulo, Brazil.
Department of Microbiology, Immunology, and Parasitology, Federal University of São Paulo (UNIFESP), São Paulo, Brazil.
ORCID: 0000-0003-1126-7563

Carolina Borsoi Moraes (CB)

Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.

Lucio H Freitas-Junior (LH)

Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.

Jorge Kalil (J)

Laboratory of Immunology, Heart Institute, School of Medicine, University of São Paulo, São Paulo, Brazil.
School of Medicine, University of São Paulo, São Paulo, Brazil.

Laura Alcântara (L)

Laboratory of Immunology, Heart Institute, School of Medicine, University of São Paulo, São Paulo, Brazil.
School of Medicine, University of São Paulo, São Paulo, Brazil.
Institute of Tropical Medicine of São Paulo, São Paulo, Brazil.

Edecio Cunha-Neto (E)

Laboratory of Immunology, Heart Institute, School of Medicine, University of São Paulo, São Paulo, Brazil.
School of Medicine, University of São Paulo, São Paulo, Brazil.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Drug Repurposing in Chagas Disease:...
questionsmedicales.fr › Eucaryotes › Animaux › Drug Repurposing in Chagas Disease:...
questionsmedicales.fr › Eucaryotes › Euglénozoaires › Kinetoplastida › Trypanosomatina › Trypanosoma › Trypanosoma cruzi › Drug Repurposing in Chagas Disease:...
questionsmedicales.fr › Techniques d'investigation › Développement de médicament › Repositionnement des médicaments › Drug Repurposing in Chagas Disease:...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Quinoléines › Aminoquinoléines › Chloroquine › Drug Repurposing in Chagas Disease:...
questionsmedicales.fr › Infection › Maladies vectorielles › Maladie de Chagas › Drug Repurposing in Chagas Disease:...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Imidazoles › Nitroimidazoles › Drug Repurposing in Chagas Disease:...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiparasitaires › Antiprotozoaires › Trypanocides › Drug Repurposing in Chagas Disease:...