Comparative Effectiveness and Safety Between Apixaban, Dabigatran, Edoxaban, and Rivaroxaban Among Patients With Atrial Fibrillation : A Multinational Population-Based Cohort Study.

BACKGROUND

Current guidelines recommend using direct oral anticoagulants (DOACs) over warfarin in patients with atrial fibrillation (AF), but head-to-head trial data do not exist to guide the choice of DOAC.

OBJECTIVE

To do a large-scale comparison between all DOACs (apixaban, dabigatran, edoxaban, and rivaroxaban) in routine clinical practice.

DESIGN

Multinational population-based cohort study.

SETTING

Five standardized electronic health care databases, which covered 221 million people in France, Germany, the United Kingdom, and the United States.

PARTICIPANTS

Patients who were newly diagnosed with AF from 2010 through 2019 and received a new DOAC prescription.

MEASUREMENTS

Database-specific hazard ratios (HRs) of ischemic stroke or systemic embolism, intracranial hemorrhage (ICH), gastrointestinal bleeding (GIB), and all-cause mortality between DOACs were estimated using a Cox regression model stratified by propensity score and pooled using a random-effects model.

RESULTS

A total of 527 226 new DOAC users met the inclusion criteria (apixaban,

LIMITATION

Residual confounding is possible.

CONCLUSION

Among patients with AF, apixaban use was associated with lower risk for GIB and similar rates of ischemic stroke or systemic embolism, ICH, and all-cause mortality compared with dabigatran, edoxaban, and rivaroxaban. This finding was consistent for patients aged 80 years or older and those with chronic kidney disease, who are often underrepresented in clinical trials.

PRIMARY FUNDING SOURCE

None.