Endoscopic Findings and Treatment of Gastric Neoplasms in Familial Adenomatous Polyposis.
Endoscopic mucosal resections
Endoscopic submucosal dissections
Familial adenomatous polyposis
Gastric neoplasms
Journal
Journal of gastric cancer
ISSN: 2093-582X
Titre abrégé: J Gastric Cancer
Pays: Korea (South)
ID NLM: 101559430
Informations de publication
Date de publication:
Oct 2022
Oct 2022
Historique:
received:
29
05
2022
revised:
09
08
2022
accepted:
23
08
2022
entrez:
31
10
2022
pubmed:
1
11
2022
medline:
1
11
2022
Statut:
ppublish
Résumé
Gastric neoplasia is a common manifestation of familial adenomatous polyposis (FAP). This study aimed to elucidate the clinical characteristics, endoscopic features including fundic gland polyposis (FGPsis), and treatment outcomes of gastric neoplasms (GNs) in patients with FAP. A total of 35 patients diagnosed with FAP, including nine patients from four pedigrees who underwent esophagogastroduodenoscopy (EGD), were investigated regarding patient characteristics, GN morphology, and treatment outcomes. Twenty-one patients (60.0%) had 38 GNs; 33 (86.8%) and 5 (13.2%) were histologically diagnosed with adenocarcinoma and adenoma, respectively. There were no specific patient characteristics related to GNs. Nodule-type GNs were more prevalent in patients with FGP than without (52.2% vs. 0.0%, P=0.002) in the upper body of the stomach. Conversely, depressed-type GNs were fewer in patients with FGPsis than in those without (13.0% vs. 73.3%, P<0.001). Slightly elevated-type GNs were observed in both groups (34.8% vs. 20.0%, P=0.538). Even within pedigrees, the background gastric mucosa and types of GNs varied. In total, 24 GNs were treated with endoscopic submucosal dissection (ESD) and eight with endoscopic mucosal resection (EMR). EMR was selected for GNs with FGPsis because of the technical difficulty of ESD, resulting in a lower en bloc resection rate (62.5% vs. 100%, P=0.014). Our study indicates the necessity of routine EGD surveillance in patients diagnosed with FAP. Notably, the morphology and location of GNs differed between patients with and without FGPsis. Endoscopic treatment and outcomes require more attention in cases of FGPsis.
Identifiants
pubmed: 36316112
pii: 22.381
doi: 10.5230/jgc.2022.22.e30
pmc: PMC9633932
doi:
Types de publication
Journal Article
Langues
eng
Pagination
381-394Subventions
Organisme : Japanese Foundation for Research and Promotion of Endoscopy
Pays : Japan
Informations de copyright
Copyright © 2022. Korean Gastric Cancer Association.
Déclaration de conflit d'intérêts
No potential conflict of interest relevant to this article was reported.
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