Transcriptional atlas of the human immune response to 13 vaccines reveals a common predictor of vaccine-induced antibody responses.
Journal
Nature immunology
ISSN: 1529-2916
Titre abrégé: Nat Immunol
Pays: United States
ID NLM: 100941354
Informations de publication
Date de publication:
12 2022
12 2022
Historique:
received:
19
04
2022
accepted:
12
09
2022
pubmed:
2
11
2022
medline:
16
12
2022
entrez:
1
11
2022
Statut:
ppublish
Résumé
Systems vaccinology has defined molecular signatures and mechanisms of immunity to vaccination. However, comparative analysis of immunity to different vaccines is lacking. We integrated transcriptional data of over 3,000 samples, from 820 adults across 28 studies of 13 vaccines and analyzed vaccination-induced signatures of antibody responses. Most vaccines induced signatures of innate immunity and plasmablasts at days 1 and 7, respectively, after vaccination. However, the yellow fever vaccine induced an early transient signature of T and B cell activation at day 1, followed by delayed antiviral/interferon and plasmablast signatures that peaked at days 7 and 14-21, respectively. Thus, there was no evidence for a 'universal signature' that predicted antibody response to all vaccines. However, accounting for the asynchronous nature of responses, we defined a time-adjusted signature that predicted antibody responses across vaccines. These results provide a transcriptional atlas of immunity to vaccination and define a common, time-adjusted signature of antibody responses.
Identifiants
pubmed: 36316475
doi: 10.1038/s41590-022-01328-6
pii: 10.1038/s41590-022-01328-6
pmc: PMC9869360
mid: NIHMS1862741
doi:
Substances chimiques
Vaccines
0
Antibodies, Viral
0
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1788-1798Subventions
Organisme : NIAID NIH HHS
ID : R37 AI048638
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI128949
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI128913
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI118608
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI057266
Pays : United States
Organisme : NIAID NIH HHS
ID : R56 AI048638
Pays : United States
Organisme : NIDDK NIH HHS
ID : R37 DK057665
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI128910
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI165527
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI128914
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI118626
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI167903
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI048638
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI089992
Pays : United States
Investigateurs
A Deckhut-Augustine
(A)
R Gottardo
(R)
E K Haddad
(EK)
D A Hafler
(DA)
E Harris
(E)
D Farber
(D)
S H Kleinstein
(SH)
O Levy
(O)
J McElrath
(J)
R R Montgomery
(RR)
B Peters
(B)
B Pulendran
(B)
A Rahman
(A)
E F Reed
(EF)
N Rouphael
(N)
M M Sarwal
(MM)
R P Sékaly
(RP)
A Fernandez-Sesma
(A)
A Sette
(A)
K Stuart
(K)
A Togias
(A)
J S Tsang
(JS)
Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2022. Springer Nature America, Inc.
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