Effect of Schistosoma haematobium infection on the cognitive functions of preschool age children and benefits of treatment from an endemic area in Zimbabwe.
Cognitive functions
Early child development
Pre-school aged children
Schistosomiasis
Journal
BMC infectious diseases
ISSN: 1471-2334
Titre abrégé: BMC Infect Dis
Pays: England
ID NLM: 100968551
Informations de publication
Date de publication:
31 Oct 2022
31 Oct 2022
Historique:
received:
01
06
2022
accepted:
14
10
2022
entrez:
1
11
2022
pubmed:
2
11
2022
medline:
3
11
2022
Statut:
epublish
Résumé
Schistosomiasis is known to affect the cognitive functions of children, however, but there is paucity of information on its impact on early childhood development in developing countries where the disease is endemic. This study aimed at determining the effects of schistosomiasis due to Schistosoma haematobium on early childhood development in children below 5 years old from Murewa District, Zimbabwe, including the benefits of treatment. Preschool age children (PSAC) under the age of 5 years were screened at baseline and at 6 months post-treatment for S. haematobium infections diagnosed using the urine filtration method. Cognitive domains were assessed using the Griffith Mental Developmental Scales III on 136 PSAC. Multivariate logistic regression was used to determine the level of association between S. haematobium infection and performance in the cognitive domains adjusting for confounding factors (i.e. nutrition, hemoglobin levels, gender and age). Median Development Quotient scores of each cognitive domain at baseline and at 6 months post-treatment were compared and quantified. After adjusting for confounding factors, PSAC infected with S. haematobium had greater odds of having lower scores in the Foundation of Learning Domain (OR = 3.9, p = 0.008), Language and Communication Domain (OR = 3.2, p = 0.017), Eye-Hand Coordination Domains (OR = 10.7, p = 0.001), Personal-Social-Emotional Domain (19.3, p = 0.001) and in the Overall General Development Domain (7.2, p = 0.011). Improvement of cognitive performance was observed at 6 months post treatment in the following Domains; Language and Communication Domain (p = 0.003), Eye-Hand Coordination Domain (p = 0.02) and General Development Domain (p = 0.006). The study showed that S. haematobium infection in PSAC is associated with lower cognitive scores in the Foundation of Learning, Language and Communication, Eye-Hand Coordination, Personal-Social-Emotional and in the Overall General Development domains. Our results strengthen the call for inclusion of PSAC in routine deworming programs for the control of urinary schistosomiasis and the need to develop locally validated tools to monitor early child development in endemic areas where resources are limited.
Sections du résumé
BACKGROUND
BACKGROUND
Schistosomiasis is known to affect the cognitive functions of children, however, but there is paucity of information on its impact on early childhood development in developing countries where the disease is endemic. This study aimed at determining the effects of schistosomiasis due to Schistosoma haematobium on early childhood development in children below 5 years old from Murewa District, Zimbabwe, including the benefits of treatment.
METHODS
METHODS
Preschool age children (PSAC) under the age of 5 years were screened at baseline and at 6 months post-treatment for S. haematobium infections diagnosed using the urine filtration method. Cognitive domains were assessed using the Griffith Mental Developmental Scales III on 136 PSAC. Multivariate logistic regression was used to determine the level of association between S. haematobium infection and performance in the cognitive domains adjusting for confounding factors (i.e. nutrition, hemoglobin levels, gender and age). Median Development Quotient scores of each cognitive domain at baseline and at 6 months post-treatment were compared and quantified.
RESULTS
RESULTS
After adjusting for confounding factors, PSAC infected with S. haematobium had greater odds of having lower scores in the Foundation of Learning Domain (OR = 3.9, p = 0.008), Language and Communication Domain (OR = 3.2, p = 0.017), Eye-Hand Coordination Domains (OR = 10.7, p = 0.001), Personal-Social-Emotional Domain (19.3, p = 0.001) and in the Overall General Development Domain (7.2, p = 0.011). Improvement of cognitive performance was observed at 6 months post treatment in the following Domains; Language and Communication Domain (p = 0.003), Eye-Hand Coordination Domain (p = 0.02) and General Development Domain (p = 0.006).
CONCLUSION
CONCLUSIONS
The study showed that S. haematobium infection in PSAC is associated with lower cognitive scores in the Foundation of Learning, Language and Communication, Eye-Hand Coordination, Personal-Social-Emotional and in the Overall General Development domains. Our results strengthen the call for inclusion of PSAC in routine deworming programs for the control of urinary schistosomiasis and the need to develop locally validated tools to monitor early child development in endemic areas where resources are limited.
Identifiants
pubmed: 36316647
doi: 10.1186/s12879-022-07784-7
pii: 10.1186/s12879-022-07784-7
pmc: PMC9620666
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
809Subventions
Organisme : The British Academy (BA) and National Institute of Health Research (NIHR), Global Health Research Programme using UK aid from UK Government
ID : (16/136/33)
Organisme : The British Academy (BA) and National Institute of Health Research (NIHR), Global Health Research Programme using UK aid from UK Government
ID : (16/136/33)
Informations de copyright
© 2022. The Author(s).
Références
Trop Med Int Health. 2020 Sep;25(9):1110-1121
pubmed: 32502300
BMC Infect Dis. 2019 Dec 19;19(1):1071
pubmed: 31856765
Annu Rev Psychol. 2002;53:371-99
pubmed: 11752490
Lancet. 2013 Aug 3;382(9890):427-451
pubmed: 23746772
Brain Behav Immun. 2017 Jan;59:233-244
pubmed: 27633985
Mol Psychiatry. 2000 Nov;5(6):604-15
pubmed: 11126391
Infect Dis Poverty. 2019 Jun 16;8(1):47
pubmed: 31202273
Brain Behav Immun. 2009 Feb;23(2):149-58
pubmed: 18793712
PLoS Negl Trop Dis. 2018 Jan 12;12(1):e0005524
pubmed: 29329293
Biomed Res Int. 2016;2016:9162631
pubmed: 27631011
Am J Trop Med Hyg. 1999 Apr;60(4):556-65
pubmed: 10348228
Eur J Clin Nutr. 2004 Jul;58(7):1022-9
pubmed: 15220944
PLoS Negl Trop Dis. 2018 Jan 12;12(1):e0005523
pubmed: 29329288
BMJ. 2002 Aug 10;325(7359):305
pubmed: 12169505
SAJCH. 2010 Dec;4(4):106-111
pubmed: 22984637
Trop Med Int Health. 2002 Feb;7(2):104-17
pubmed: 11841700
PLoS Negl Trop Dis. 2018 Feb 8;12(2):e0006144
pubmed: 29420537
Rev Inst Med Trop Sao Paulo. 1972 Nov-Dec;14(6):397-400
pubmed: 4675644
Ann Trop Med Parasitol. 1998 Dec;92(8):851-8
pubmed: 10396345
Ann Clin Microbiol Antimicrob. 2011 Feb 07;10:5
pubmed: 21294922
Am J Trop Med Hyg. 2005 May;72(5):540-548
pubmed: 15891127
Res Dev Disabil. 2014 Jul;35(7):1789-801
pubmed: 24679548
J Nutr. 2006 Jan;136(1):183-8
pubmed: 16365080
Proc Biol Sci. 1992 Feb 22;247(1319):77-81
pubmed: 1349184
Adv Exp Med Biol. 2006;582:23-33
pubmed: 16802616
Food Nutr Bull. 2005 Jun;26(2 Suppl 2):S186-92
pubmed: 16075568
Infect Agent Cancer. 2020 Oct 06;15:59
pubmed: 33042215
Lancet. 2007 Jan 6;369(9555):60-70
pubmed: 17208643
Intelligence. 2015 Jan-Feb;48:30-36
pubmed: 26640306
J Child Psychol Psychiatry. 2013 Apr;54(4):367-77
pubmed: 23240891
Soc Sci Res. 2009 Jun;38(2):412-37
pubmed: 19827182
Front Microbiol. 2020 Jan 31;10:3092
pubmed: 32082267
Neuroscience. 2012 Aug 2;216:133-42
pubmed: 22554776
Lancet Glob Health. 2017 Jul;5(7):e688-e698
pubmed: 28619227
Brain Res Bull. 2005 Sep 30;67(1-2):24-9
pubmed: 16140159
Tropenmed Parasitol. 1982 Dec;33(4):227-8
pubmed: 7164164
Science. 2003 Dec 5;302(5651):1760-5
pubmed: 14615545
Neuropsychiatr Dis Treat. 2009;5:5-14
pubmed: 19557094
World J Gastroenterol. 2004 Jun 15;10(12):1836-7
pubmed: 15188519
J Nutr. 2010 Feb;140(2):348-54
pubmed: 20007336
Am J Trop Med Hyg. 2010 Nov;83(5):1048-55
pubmed: 21036836
Parasitology. 2012 Jun;139(7):835-41
pubmed: 22313588
Nat Rev Immunol. 2002 Jul;2(7):499-511
pubmed: 12094224
Curr Ther Res Clin Exp. 2019 Jun 22;91:5-9
pubmed: 31372189
Am J Trop Med Hyg. 1989 Oct;41(4):445-53
pubmed: 2508502
BMC Public Health. 2008 Jun 06;8:202
pubmed: 18534035
PLoS One. 2017 Jul 26;12(7):e0181975
pubmed: 28746403
Ghana Med J. 2014 Dec;48(4):228-33
pubmed: 25709140
J Trop Med. 2013;2013:283619
pubmed: 23840222
Demography. 2000 Nov;37(4):431-47
pubmed: 11086569
Curr Gastroenterol Rep. 2001 Aug;3(4):293-303
pubmed: 11469998