A canine model of aortic arch aneurysm created with autologous pericardium.
Animal model
Aortic aneurysm
Aortic arch
Ascending aorta
Pericardium patch
Journal
Journal of interventional medicine
ISSN: 2590-0293
Titre abrégé: J Interv Med
Pays: China
ID NLM: 9918265602006676
Informations de publication
Date de publication:
Aug 2022
Aug 2022
Historique:
received:
12
04
2022
revised:
05
06
2022
accepted:
07
06
2022
entrez:
1
11
2022
pubmed:
2
11
2022
medline:
2
11
2022
Statut:
epublish
Résumé
To establish a canine model of aortic arch aneurysm that is suitable for research on new devices and techniques applied to the aortic arch. Fifteen mongrel dogs underwent surgery. The autologous pericardial patch was sewn on the aortotomy site in the anterior wall of the aortic arch. The animals were followed up for 3 months postoperatively. Computed tomography angiography was used to visualize and measure the aneurysm model. Hematoxylin and eosin staining was used to observe the histological characteristics of the aneurysm model. Changes in aneurysm diameter over time were analyzed using analysis of variance. One dog died of hemorrhage during surgery. Fourteen dogs survived the surgical procedure. Two of them died on the first postoperative day because of ruptures at the suturing margin. The diameter of the aneurysm model was twice as large as that of the aortic arch. There was no significant change in the maximum diameter of the aneurysm model during the follow-up period. We established a controllable and stable aortic arch aneurysm model created with an autologous pericardium patch. The aneurysm model can be used to research endoleaks after thoracic endovascular aortic repair and new endovascular techniques can be applied to the aortic arch.
Sections du résumé
Background
UNASSIGNED
To establish a canine model of aortic arch aneurysm that is suitable for research on new devices and techniques applied to the aortic arch.
Materials and methods
UNASSIGNED
Fifteen mongrel dogs underwent surgery. The autologous pericardial patch was sewn on the aortotomy site in the anterior wall of the aortic arch. The animals were followed up for 3 months postoperatively. Computed tomography angiography was used to visualize and measure the aneurysm model. Hematoxylin and eosin staining was used to observe the histological characteristics of the aneurysm model. Changes in aneurysm diameter over time were analyzed using analysis of variance.
Results
UNASSIGNED
One dog died of hemorrhage during surgery. Fourteen dogs survived the surgical procedure. Two of them died on the first postoperative day because of ruptures at the suturing margin. The diameter of the aneurysm model was twice as large as that of the aortic arch. There was no significant change in the maximum diameter of the aneurysm model during the follow-up period.
Conclusions
UNASSIGNED
We established a controllable and stable aortic arch aneurysm model created with an autologous pericardium patch. The aneurysm model can be used to research endoleaks after thoracic endovascular aortic repair and new endovascular techniques can be applied to the aortic arch.
Identifiants
pubmed: 36317141
doi: 10.1016/j.jimed.2022.06.005
pii: S2096-3602(22)00039-4
pmc: PMC9617150
doi:
Types de publication
Journal Article
Langues
eng
Pagination
133-137Informations de copyright
© 2022 Shanghai Journal of Interventional Radiology Press. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd.
Déclaration de conflit d'intérêts
We declare that we do not have any commercial or associative interest that represents a conflict of interest in connection with the work submitted.
Références
Cardiovasc Pathol. 2011 Mar-Apr;20(2):114-23
pubmed: 20133168
Ann Thorac Cardiovasc Surg. 2013;19(2):131-5
pubmed: 22971721
Interact Cardiovasc Thorac Surg. 2021 Oct 29;33(5):746-754
pubmed: 34056647
Ann Vasc Surg. 2012 Jan;26(1):55-66
pubmed: 22176875
J Endovasc Ther. 2000 Feb;7(1):47-67
pubmed: 10772749
J Vasc Interv Radiol. 2005 Apr;16(4):515-9
pubmed: 15802451
J Vasc Surg. 2019 Sep;70(3):672-682.e1
pubmed: 30871889
J Am Heart Assoc. 2016 May 03;5(5):
pubmed: 27143353
J Endovasc Ther. 2017 Feb;24(1):89-96
pubmed: 27760812
J Vasc Interv Radiol. 2008 Jun;19(6 Suppl):S57-62
pubmed: 18502388
J Vasc Surg. 2008 Nov;48(5):1306-14
pubmed: 18639416
Vasc Endovascular Surg. 2011 Jan;45(1):39-45
pubmed: 20829240
Eur J Vasc Endovasc Surg. 2009 Nov;38(5):603-7
pubmed: 19660967
J Endovasc Ther. 2002 Jun;9 Suppl 2:II32-8
pubmed: 12166839
J Cardiovasc Surg (Torino). 2015 Aug;56(4):503-11
pubmed: 25765852
Mayo Clin Proc. 2004 Feb;79(2):176-80
pubmed: 14959911
J Endovasc Ther. 2020 Apr;27(2):252-257
pubmed: 32186260
Atherosclerosis. 2016 Sep;252:40-49
pubmed: 27497884
Vasc Endovascular Surg. 2014 Jul-Aug;48(5-6):383-7
pubmed: 24951293
Ann Cardiothorac Surg. 2018 May;7(3):406-413
pubmed: 30155420
J Endovasc Ther. 2020 Oct;27(5):792-800
pubmed: 32431247
Kaohsiung J Med Sci. 2013 Apr;29(4):194-9
pubmed: 23541264
J Card Surg. 2021 Nov;36(11):4292-4300
pubmed: 34405439
J Am Coll Cardiol. 2010 Mar 2;55(9):841-57
pubmed: 20185035
J Thorac Cardiovasc Surg. 2016 Apr;151(4):1203-12
pubmed: 26995624
J Surg Res. 2003 Nov;115(1):157-63
pubmed: 14572787
Surgery. 2016 Jun;159(6):1654-1667
pubmed: 26936526