Biological evaluation, docking studies, and

Animals Chlorocebus aethiops Humans ErbB Receptors / metabolism Protein Kinase Inhibitors / metabolism Molecular Docking Simulation Drug Screening Assays, Antitumor Vero Cells Caco-2 Cells Lung Neoplasms / pathology Antineoplastic Agents / pharmacology Cell Line, Tumor Cell Proliferation Structure-Activity Relationship Mutation Pyrimidines / pharmacology Pyridines / pharmacology Molecular Structure
EGFR Pyridine/pyrimidine derivatives in silico in vitro

Journal

Journal of enzyme inhibition and medicinal chemistry
ISSN: 1475-6374
Titre abrégé: J Enzyme Inhib Med Chem
Pays: England
ID NLM: 101150203

Informations de publication

Date de publication:
Dec 2023
Historique:
entrez: 1 11 2022
pubmed: 2 11 2022
medline: 3 11 2022
Statut: ppublish

Résumé

Herein, a set of pyridine and pyrimidine derivatives were assessed for their impact on the cell cycle and apoptosis. Human breast cancer (MCF7), hepatocellular carcinoma (HEPG2), larynx cancer (HEP2), lung cancer (H460), colon cancers (HCT116 and Caco2), and hypopharyngeal cancer (FADU), and normal Vero cell lines were used. Compounds

Identifiants

DOI: 10.1080/14756366.2022.2135512 PMID: 36317648 PMC: PMC9635468
pubmed: 36317648
doi: 10.1080/14756366.2022.2135512
pmc: PMC9635468
doi:

Substances chimiques

ErbB Receptors EC 2.7.10.1
Protein Kinase Inhibitors 0
Antineoplastic Agents 0
Pyrimidines 0
Pyridines 0
EGFR protein, human EC 2.7.10.1

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

176-191

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Auteurs

Tarfah Al-Warhi (T)

Department of Chemistry, College of Science, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.

Ahmed A Al-Karmalawy (AA)

Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ahram Canadian University, Giza, Egypt.
ORCID: 0000-0002-8173-6073

Ayman Abo Elmaaty (AA)

Department of Medicinal Chemistry, Faculty of Pharmacy, Port Said University, Port Said, Egypt.

Maha A Alshubramy (MA)

Department of Chemistry, College of Science, Qassim University, Buraydah, Saudi Arabia.

Marwa Abdel-Motaal (M)

Department of Chemistry, College of Science, Qassim University, Buraydah, Saudi Arabia.
Chemistry Department, Faculty of Science, Mansoura University, Mansoura, Egypt.

Taghreed A Majrashi (TA)

Department of Pharmacognosy, College of Pharmacy, King Khalid University, Abha, Saudi Arabia.

Medhat Asem (M)

College of Engineering and Information Technology, Onaizah Colleges, Al-Qassim, Saudi Arabia.

Ahmed Nabil (A)

Research Center for Functional Materials, National Institute for Materials Science (NIMS), Tsukuba, Japan.
Biotechnology and Life Sciences Department, Faculty of Postgraduate Studies for Advanced Sciences (PSAS), Beni-Suef University, Beni-Suef, Egypt.

Wagdy M Eldehna (WM)

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, Egypt.
School of Biotechnology, Badr University in Cairo, Badr City, Egypt.
ORCID: 0000-0001-6996-4017

Marwa Sharaky (M)

Cancer Biology Department, Pharmacology Unit, National Cancer Institute (NCI), Cairo University, Cairo, Egypt.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Biological evaluation, docking studies, and
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Cercopithecidae › Cercopithecinae › Cercopithecus › Cercopithecus aethiops › Biological evaluation, docking studies, and
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Biological evaluation, docking studies, and
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur facteur croissance › Récepteurs ErbB › Biological evaluation, docking studies, and
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Inhibiteurs de protéines kinases › Biological evaluation, docking studies, and
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Biological evaluation, docking studies, and
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Tests de criblage d'agents antitumoraux › Biological evaluation, docking studies, and
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules Vero › Biological evaluation, docking studies, and
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules Caco-2 › Biological evaluation, docking studies, and
questionsmedicales.fr › Maladies de l'appareil respiratoire › Tumeurs de l'appareil respiratoire › Tumeurs du poumon › Biological evaluation, docking studies, and
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Biological evaluation, docking studies, and
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Biological evaluation, docking studies, and
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questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Biological evaluation, docking studies, and
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Biological evaluation, docking studies, and
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyrimidines › Biological evaluation, docking studies, and
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyridines › Biological evaluation, docking studies, and
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Biological evaluation, docking studies, and