Pregnancies complicated by gestational diabetes and fetal growth restriction: an analysis of maternal and fetal body composition using magnetic resonance imaging.
Journal
Journal of perinatology : official journal of the California Perinatal Association
ISSN: 1476-5543
Titre abrégé: J Perinatol
Pays: United States
ID NLM: 8501884
Informations de publication
Date de publication:
01 2023
01 2023
Historique:
received:
16
07
2022
accepted:
20
10
2022
revised:
19
10
2022
pubmed:
3
11
2022
medline:
18
1
2023
entrez:
2
11
2022
Statut:
ppublish
Résumé
Maternal body composition may influence fetal body composition. The objective of this pilot study was to investigate the relationship between maternal and fetal body composition. Three pregnant women cohorts were studied: healthy, gestational diabetes (GDM), and fetal growth restriction (FGR). Maternal body composition (visceral adipose tissue volume (VAT), subcutaneous adipose tissue volume (SAT), pancreatic and hepatic proton-density fat fraction (PDFF) and fetal body composition (abdominal SAT and hepatic PDFF) were measured using MRI between 30 to 36 weeks gestation. Compared to healthy and FGR fetuses, GDM fetuses had greater hepatic PDFF (5.2 [4.2, 5.5]% vs. 3.2 [3, 3.3]% vs. 1.9 [1.4, 3.7]%, p = 0.004). Fetal hepatic PDFF was associated with maternal SAT (r = 0.47, p = 0.02), VAT (r = 0.62, p = 0.002), and pancreatic PDFF (r = 0.54, p = 0.008). When controlling for maternal SAT, GDM increased fetal hepatic PDFF by 0.9 ([0.51, 1.3], p = 0.001). In this study, maternal SAT, VAT, and GDM status were positively associated with fetal hepatic PDFF.
Identifiants
pubmed: 36319757
doi: 10.1038/s41372-022-01549-5
pii: 10.1038/s41372-022-01549-5
pmc: PMC9840659
mid: NIHMS1851343
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
44-51Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK124417
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01-124417-01
Pays : United States
Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Nature America, Inc.
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