Investigation Around Cases of Crimean-Congo Hemorrhagic Fever-Mauritania, 2022.
Crimean-Congo hemorrhagic fever
Mauritania
arbovirus
Journal
Open forum infectious diseases
ISSN: 2328-8957
Titre abrégé: Open Forum Infect Dis
Pays: United States
ID NLM: 101637045
Informations de publication
Date de publication:
Oct 2022
Oct 2022
Historique:
received:
02
08
2022
accepted:
10
10
2022
entrez:
2
11
2022
pubmed:
3
11
2022
medline:
3
11
2022
Statut:
epublish
Résumé
Crimean-Congo hemorrhagic fever (CCHF) is a zoonotic arbovirosis. Humans are infected by tick bites or contact with blood of infected animals. CCHF can be responsible for severe outbreaks due to human-to-human transmission. Our aims were to increase awareness and promote the search for risk factors and disease monitoring to prevent CCHF epidemic, capacity building, appropriate measures to treat patients, and information for the local population. During the outbreak of hemorrhagic fever from February to May 2022, blood samples were collected from 88 patients suspected to be infected with the virus. Diagnosis was established by reverse-transcription polymerase chain reaction (RT-PCR) and/or enzyme-linked immunosorbent assay. CCHF was confirmed by RT-PCR in 7 of 88 (8%) patients. Ticks were found in cattle, sheep, or goats in the areas where the subjects resided, with the exception of 1 CCHF-positive patient in close contact with fresh animal meat. Exposure to potential risk factors was found in all patients. The interval between the onset of symptoms and hospital admission was 2-3 days. All 7 patients were admitted to our hospital and treated promptly by blood transfusion. Two patients died. Mortality is high in patients with the hemorrhagic form of CCHF. Disease prevention is necessary by strengthening vector control, avoiding contact and consumption of organic products from diseased animals, and vaccinating animals in areas where the disease is endemic. Furthermore, it is essential to establish management procedures for patients infected with CCHF virus.
Sections du résumé
Background
UNASSIGNED
Crimean-Congo hemorrhagic fever (CCHF) is a zoonotic arbovirosis. Humans are infected by tick bites or contact with blood of infected animals. CCHF can be responsible for severe outbreaks due to human-to-human transmission. Our aims were to increase awareness and promote the search for risk factors and disease monitoring to prevent CCHF epidemic, capacity building, appropriate measures to treat patients, and information for the local population.
Methods
UNASSIGNED
During the outbreak of hemorrhagic fever from February to May 2022, blood samples were collected from 88 patients suspected to be infected with the virus. Diagnosis was established by reverse-transcription polymerase chain reaction (RT-PCR) and/or enzyme-linked immunosorbent assay.
Results
UNASSIGNED
CCHF was confirmed by RT-PCR in 7 of 88 (8%) patients. Ticks were found in cattle, sheep, or goats in the areas where the subjects resided, with the exception of 1 CCHF-positive patient in close contact with fresh animal meat. Exposure to potential risk factors was found in all patients. The interval between the onset of symptoms and hospital admission was 2-3 days. All 7 patients were admitted to our hospital and treated promptly by blood transfusion. Two patients died.
Conclusions
UNASSIGNED
Mortality is high in patients with the hemorrhagic form of CCHF. Disease prevention is necessary by strengthening vector control, avoiding contact and consumption of organic products from diseased animals, and vaccinating animals in areas where the disease is endemic. Furthermore, it is essential to establish management procedures for patients infected with CCHF virus.
Identifiants
pubmed: 36320199
doi: 10.1093/ofid/ofac534
pii: ofac534
pmc: PMC9605700
doi:
Types de publication
Journal Article
Langues
eng
Pagination
ofac534Informations de copyright
© The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America.
Références
Int J Infect Dis. 2017 May;58:58-64
pubmed: 28249811
Sci Rep. 2021 Jun 16;11(1):12639
pubmed: 34135365
Lancet Infect Dis. 2020 Nov;20(11):1324-1338
pubmed: 32593318
PLoS Negl Trop Dis. 2021 Apr 22;15(4):e0009299
pubmed: 33886556
Vector Borne Zoonotic Dis. 2017 Jul;17(7):510-513
pubmed: 28514225
Hum Vaccin Immunother. 2016;12(2):519-27
pubmed: 26309231
Acta Parasitol. 2021 Sep;66(3):1086-1088
pubmed: 33674967
Emerg Infect Dis. 2016 Jul;22(7):1305-6
pubmed: 27315138
Heliyon. 2021 Oct 12;7(10):e08161
pubmed: 34703927
J Hosp Infect. 2020 May;105(1):43-52
pubmed: 31821852
Antiviral Res. 2013 Oct;100(1):159-89
pubmed: 23906741
Emerg Infect Dis. 2004 Dec;10(12):2143-9
pubmed: 15663851
Infect Disord Drug Targets. 2017;17(2):143-145
pubmed: 28124602
Med Mal Infect. 2019 Nov;49(8):574-585
pubmed: 31607406
Front Vet Sci. 2022 Sep 13;9:938601
pubmed: 36176697
Med Sci (Paris). 2021 Feb;37(2):135-140
pubmed: 33591256
F1000Res. 2018 Oct 29;7:
pubmed: 30416710
Vector Borne Zoonotic Dis. 2017 Aug;17(8):582-587
pubmed: 28605299
PLoS Negl Trop Dis. 2021 Apr 12;15(4):e0009228
pubmed: 33844691
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2015 Jul;58(7):714-20
pubmed: 25963644
Parasit Vectors. 2021 Jun 29;14(1):342
pubmed: 34187526
Emerg Infect Dis. 2020 Apr;26(4):817-818
pubmed: 32187505
Int J Infect Dis. 2013 Dec;17(12):e1160-5
pubmed: 24084247
J Clin Microbiol. 2020 Mar 25;58(4):
pubmed: 32024724