Dietary Flavonoids and Adult Neurogenesis: Potential Implications for Brain Aging.
Flavonoids
adult neurogenesis
aging
brain
diet
neurodegeneration
Journal
Current neuropharmacology
ISSN: 1875-6190
Titre abrégé: Curr Neuropharmacol
Pays: United Arab Emirates
ID NLM: 101157239
Informations de publication
Date de publication:
2023
2023
Historique:
received:
16
03
2022
revised:
27
07
2022
accepted:
19
08
2022
pubmed:
3
11
2022
medline:
28
3
2023
entrez:
2
11
2022
Statut:
ppublish
Résumé
Adult neurogenesis deficiency has been proposed to be a common hallmark in different age-related neurodegenerative diseases. The administration of flavonoids is currently reported as a potentially beneficial strategy for preventing brain aging alterations, including adult neurogenesis decline. Flavonoids are a class of plant-derived dietary polyphenols that have drawn attention for their neuroprotective and pro-cognitive effects. Although they undergo extensive metabolism and localize in the brain at low concentrations, flavonoids are now believed to improve cerebral vasculature and interact with signal transduction cascades involved in the regulation of adult neurogenesis. Furthermore, many dietary flavonoids have been shown to reduce oxidative stress and neuroinflammation, improving the neuronal microenvironment where adult neurogenesis occurs. The overall goal of this review is to summarize the evidence supporting the role of flavonoids in modulating adult neurogenesis as well as to highlight how these dietary agents may be promising candidates in restoring healthy brain function during physiological and pathological aging.
Identifiants
pubmed: 36321225
pii: CN-EPUB-127284
doi: 10.2174/1570159X21666221031103909
pmc: PMC10207917
doi:
Substances chimiques
Polyphenols
0
Flavonoids
0
Types de publication
Review
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
651-668Informations de copyright
Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
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