Mesenchymal stem cells: A novel treatment option for primary sclerosing cholangitis.
biliary stricture
cholangiocytes
hepatocytes
mesenchymal stem cells
organoids
primary sclerosing cholangitis
Journal
Cell biology international
ISSN: 1095-8355
Titre abrégé: Cell Biol Int
Pays: England
ID NLM: 9307129
Informations de publication
Date de publication:
Feb 2023
Feb 2023
Historique:
revised:
06
10
2022
received:
19
04
2022
accepted:
11
10
2022
pubmed:
3
11
2022
medline:
17
1
2023
entrez:
2
11
2022
Statut:
ppublish
Résumé
Primary sclerosing cholangitis (PSC) is a progressive liver disease for which there is no effective therapy. Hepatocytes and cholangiocytes from a PSC patient were cocultured with mesenchymal stem cells (MSCs) to assess in vitro change. A single patient with progressive PSC was treated with 150 million MSCs via direct injection into the common bile duct. Coculture of MSCs with cholangiocytes and hepatocytes showed in vitro improvement. Local delivery of MSCs into a single patient with progressive PSC was safe. Radiographic and endoscopic evaluation showed stable distribution of multifocal structuring in the early postoperative period. MSCs may be effective for the treatment of PSC.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
467-479Informations de copyright
© 2022 The Authors. Cell Biology International published by John Wiley & Sons Ltd on behalf of International Federation of Cell Biology.
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