Brain
Brain involvement
COVID-19
FDG PET
Long COVID
Non-hospitalized
Outpatients
PET
Post-COVID-19 conditions
Journal
European journal of nuclear medicine and molecular imaging
ISSN: 1619-7089
Titre abrégé: Eur J Nucl Med Mol Imaging
Pays: Germany
ID NLM: 101140988
Informations de publication
Date de publication:
03 2023
03 2023
Historique:
received:
01
08
2022
accepted:
16
10
2022
pubmed:
3
11
2022
medline:
18
2
2023
entrez:
2
11
2022
Statut:
ppublish
Résumé
Brain We retrospectively included 28 consecutive outpatients who presented with post-COVID-19 conditions between September 2020 and May 2022 and who satisfied the WHO definition, and had a brain Outpatients with post-COVID-19 conditions exhibited diffuse hypometabolism predominantly involving right frontal and temporal lobes including the orbito-frontal cortex and internal temporal areas. Metabolism in these clusters was inversely correlated with the number of symptoms during the initial infection (r = - 0.44, p = 0.02) and with the duration of symptoms (r = - 0.39, p = 0.04). Asthenia and cardiovascular, digestive, and neurological disorders during the acute phase and asthenia and language disorders during the chronic phase (p ≤ 0.04) were associated with these hypometabolic clusters. Outpatients with post-COVID-19 conditions exhibited extensive hypometabolic right fronto-temporal clusters. Patients with more numerous symptoms during the initial phase and with a longer duration of symptoms were at higher risk of persistent brain involvement.
Sections du résumé
BACKGROUND
Brain
METHODS
We retrospectively included 28 consecutive outpatients who presented with post-COVID-19 conditions between September 2020 and May 2022 and who satisfied the WHO definition, and had a brain
RESULTS
Outpatients with post-COVID-19 conditions exhibited diffuse hypometabolism predominantly involving right frontal and temporal lobes including the orbito-frontal cortex and internal temporal areas. Metabolism in these clusters was inversely correlated with the number of symptoms during the initial infection (r = - 0.44, p = 0.02) and with the duration of symptoms (r = - 0.39, p = 0.04). Asthenia and cardiovascular, digestive, and neurological disorders during the acute phase and asthenia and language disorders during the chronic phase (p ≤ 0.04) were associated with these hypometabolic clusters.
CONCLUSION
Outpatients with post-COVID-19 conditions exhibited extensive hypometabolic right fronto-temporal clusters. Patients with more numerous symptoms during the initial phase and with a longer duration of symptoms were at higher risk of persistent brain involvement.
Identifiants
pubmed: 36322190
doi: 10.1007/s00259-022-06013-2
pii: 10.1007/s00259-022-06013-2
pmc: PMC9628394
doi:
Substances chimiques
Fluorodeoxyglucose F18
0Z5B2CJX4D
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1084-1089Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
Références
Verger A, Kas A, Dudouet P, Goehringer F, Salmon-Ceron D, Guedj E. Visual interpretation of brain hypometabolism related to neurological long COVID: a French multicentric experience. Eur J Nucl Med Mol Imaging. 2022;49:3197–202.
doi: 10.1007/s00259-022-05753-5
pubmed: 35320385
pmcid: 8941296
Verger A, Barthel H, Tolboom N, Fraioli F, Cecchin D, Albert NL, et al. 2-[18F]-FDG PET for imaging brain involvement in patients with long COVID: perspective of the EANM Neuroimaging Committee. Eur J Nucl Med Mol Imaging. 2022;s00259–022–05913–7.
A clinical case definition of post COVID-19 condition by a Delphi consensus. World Health Organisation website. [Internet]. 2021. Available from: https://www.who.int/publications/i/item/WHO-2019-nCoV-Post_COVID-19_condition-Clinical_case_definition-2021 . Accessed 26 Sept 2022.
Guedj E, Campion JY, Dudouet P, Kaphan E, Bregeon F, Tissot-Dupont H, et al. 18F-FDG brain PET hypometabolism in patients with long COVID. Eur J Nucl Med Mol Imaging. 2021;48:2823–33.
doi: 10.1007/s00259-021-05215-4
pubmed: 33501506
pmcid: 7837643
Sollini M, Morbelli S, Ciccarelli M, Cecconi M, Aghemo A, Morelli P, et al. Long COVID hallmarks on [18F]FDG-PET/CT: a case-control study. Eur J Nucl Med Mol Imaging. 2021;48:3187–97.
doi: 10.1007/s00259-021-05294-3
pubmed: 33677642
pmcid: 7937050
Dressing A, Bormann T, Blazhenets G, Schroeter N, Walter LI, Thurow J, et al. Neuropsychological profiles and cerebral glucose metabolism in neurocognitive Long COVID-syndrome. J Nucl Med. 2021;jnumed.121.262677.
Meyer PT, Hellwig S, Blazhenets G, Hosp JA. Molecular imaging findings on acute and long-term effects of COVID-19 on the brain: a systematic review. J Nucl Med. 2022;jnumed.121.263085.
Augustin M, Schommers P, Stecher M, Dewald F, Gieselmann L, Gruell H, et al. Post-COVID syndrome in non-hospitalised patients with COVID-19: a longitudinal prospective cohort study. The Lancet Regional Health - Europe. 2021;6: 100122.
doi: 10.1016/j.lanepe.2021.100122
pubmed: 34027514
pmcid: 8129613
Guedj E, Varrone A, Boellaard R, Albert NL, Barthel H, van Berckel B, et al. EANM procedure guidelines for brain PET imaging using [18F]FDG, version 3. Eur J Nucl Med Mol Imaging. 2022;49:632–51. Accessed 26 Sept 2022.
WHO COVID-19: case definitions. World Health Organisation website. [Internet]. 2020. Available from: https://www.who.int/publications/i/item/WHO-2019-nCoV-Surveillance_Case_Definition-2020.2 . Accessed 26 Sept 2022.
Michelen M, Manoharan L, Elkheir N, Cheng V, Dagens A, Hastie C, et al. Characterising long COVID: a living systematic review. BMJ Glob Health. 2021;6: e005427.
doi: 10.1136/bmjgh-2021-005427
pubmed: 34580069
Heiss W-D. PET in coma and in vegetative state: PET in coma and in vegetative state. Eur J Neurol. 2012;19:207–11.
doi: 10.1111/j.1468-1331.2011.03489.x
pubmed: 21797946
Carota A, Bogousslavsky J. Minor hemisphere major syndromes. In: Bogousslavsky J, editor. Frontiers of Neurology and Neuroscience [Internet]. S. Karger AG; 2018 [cited 2022 Sep 26]. p. 1–13. Available from: https://www.karger.com/Article/FullText/475690
Fond G, Masson M, Lançon C, Richieri R, Guedj E. The neuroinflammatory pathways of post-SARS-CoV-2 psychiatric disorders. L’Encéphale. 2021;47:399–400.
doi: 10.1016/j.encep.2021.08.001
pubmed: 34593237
pmcid: 8403666
Sudre CH, Murray B, Varsavsky T, Graham MS, Penfold RS, Bowyer RC, et al. Attributes and predictors of long COVID. Nat Med. 2021;27:626–31.
doi: 10.1038/s41591-021-01292-y
pubmed: 33692530
pmcid: 7611399
Guedj E, Morbelli S, Kaphan E, Campion J-Y, Dudouet P, Ceccaldi M, et al. From early limbic inflammation to long COVID sequelae. Brain. 2021;144:e65–e65.
doi: 10.1093/brain/awab215
pubmed: 34142116