Prolonged replication of BA.1 and BA.2 Omicron lineages compared to Delta variant in nasopharyngeal samples from COVID-19 patients.
BA.1
BA.2
Kinetic
SARS-CoV-2
Viral load
Journal
Infectious diseases now
ISSN: 2666-9919
Titre abrégé: Infect Dis Now
Pays: France
ID NLM: 101775152
Informations de publication
Date de publication:
Feb 2023
Feb 2023
Historique:
received:
12
07
2022
revised:
18
10
2022
accepted:
24
10
2022
pubmed:
3
11
2022
medline:
15
2
2023
entrez:
2
11
2022
Statut:
ppublish
Résumé
We aimed to characterize and compare the viral loads (VL) of the Omicron BA.1 and BA.2 lineages and the Delta variant in nasopharyngeal samples from newly diagnosed COVID-19 patients and their kinetics over time. The kinetics of the VL were measured on the CT data from 215 SARS-CoV-2 positive patients who presented at least two positive PCRs a day apart and were screened for SARS-CoV-2 viral lineages. We observed no significant difference in median CT value during the first diagnostic test between the Delta variant and the two Omicron lineages. However, the kinetics of CT decreases for the BA.1 and BA.2 lineage were significantly lengthier in time than the kinetics for the Delta variant. The BA.2 lineage presented lower median CT value (-2 CT) (inversely proportional to the VL) than the BA.1 lineage. BA.2 Omicron lineage presented higher VL than BA.1 Omicron lineage at diagnostic. Omicron BA.1 and BA.2 lineages have more prolonged replication than the Delta variant.
Identifiants
pubmed: 36323397
pii: S2666-9919(22)00232-9
doi: 10.1016/j.idnow.2022.10.001
pmc: PMC9618294
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
104629Informations de copyright
Copyright © 2022 Elsevier Masson SAS. All rights reserved.
Références
Immun Inflamm Dis. 2022 Mar;10(3):e580
pubmed: 34904379
Nature. 2021 Dec;600(7888):197-199
pubmed: 34857948
J Infect. 2021 Oct;83(4):e1-e3
pubmed: 34419559
J Infect. 2022 Aug;85(2):174-211
pubmed: 35490739
World J Crit Care Med. 2021 Jul 9;10(4):132-150
pubmed: 34316448
Science. 2022 Feb 18;375(6582):760-764
pubmed: 35050643
Nat Commun. 2023 Mar 22;14(1):1577
pubmed: 36949041
Nat Med. 2022 Jul;28(7):1491-1500
pubmed: 35395151