Persistence of DNA from canine parvovirus modified-live virus in canine tissues.
Canine parvovirus
Carnivore protoparvovirus 1
Modified-live virus vaccine
Tissue persistence
Journal
Veterinary research communications
ISSN: 1573-7446
Titre abrégé: Vet Res Commun
Pays: Switzerland
ID NLM: 8100520
Informations de publication
Date de publication:
Jun 2023
Jun 2023
Historique:
received:
01
08
2022
accepted:
22
09
2022
medline:
26
5
2023
pubmed:
4
11
2022
entrez:
3
11
2022
Statut:
ppublish
Résumé
Canine parvovirus (CPV-2) modified-live virus vaccine strain can replicate in lymphoid tissues and intestinal mucosa after administration, being shed through canine faeces. Detection of vaccine strains has been reported in the bloodstream and faeces, potentially interfering with molecular diagnostic tests. The persistence of these strains in canine tissues has not yet been described. With this aim, canine tissues were tested during a molecular survey to screen for the presence of canine enteric viruses. Tissue samples from 165 dead dogs were tested by a conventional PCR assay. Positive samples and five commercial vaccines were subjected to sequence analysis. Vaccinal strains were detected and virus load was measured by using a set of real-time PCR assays using minor-groove binder (MGB) probes. Seventy-five dogs (45.4%) tested positive for CPV-2. Strains from 70 dogs were characterised as field variants. The presence of CPV sequences of vaccine origin was observed in the spleen, intestine, and mesenteric lymph nodes of five young dogs. Vaccinal strains were detected from 12 to 24 days after the last vaccine administration. Viral loads comprised between 6.3 × 10
Identifiants
pubmed: 36323836
doi: 10.1007/s11259-022-10008-7
pii: 10.1007/s11259-022-10008-7
pmc: PMC9630067
doi:
Substances chimiques
Viral Vaccines
0
Vaccines, Attenuated
0
DNA, Viral
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
567-574Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Nature B.V.
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