Integrative epigenomic analyses of small cell lung cancer cells demonstrates the clinical translational relevance of gene body methylation.
Cancer
Cancer systems biology
Epigenetics
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
18 Nov 2022
18 Nov 2022
Historique:
received:
01
04
2022
revised:
15
06
2022
accepted:
10
10
2022
entrez:
3
11
2022
pubmed:
4
11
2022
medline:
4
11
2022
Statut:
epublish
Résumé
DNA methylation is a key regulator of gene expression and a clinical therapeutic predictor. We examined global DNA methylation beyond the generally used promoter areas in human small cell lung cancer (SCLC) and find that gene body methylation is a robust positive predictor of gene expression. Combining promoter and gene body methylation better predicts gene expression than promoter methylation alone including genes involved in the neuroendocrine classification of SCLC and the expression of therapeutically relevant genes including
Identifiants
pubmed: 36325065
doi: 10.1016/j.isci.2022.105338
pii: S2589-0042(22)01610-8
pmc: PMC9619308
doi:
Types de publication
Journal Article
Langues
eng
Pagination
105338Subventions
Organisme : NCI NIH HHS
ID : P30 CA142543
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA070907
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA213338
Pays : United States
Organisme : NCI NIH HHS
ID : U24 CA213274
Pays : United States
Déclaration de conflit d'intérêts
The authors declare no competing interests. JDM receives royalties from the NCI and UT Southwestern Medical Center for the distribution of human tumor cell lines.
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