A new small molecule DHODH-inhibitor [KIO-100 (PP-001)] targeting activated T cells for intraocular treatment of uveitis - A phase I clinical trial.
clinical phase 1 trial
experimental autoimmune uveitis
humans
intravitreal therapy
macular edema
rat
uveitis
visual acuity
Journal
Frontiers in medicine
ISSN: 2296-858X
Titre abrégé: Front Med (Lausanne)
Pays: Switzerland
ID NLM: 101648047
Informations de publication
Date de publication:
2022
2022
Historique:
received:
19
08
2022
accepted:
26
09
2022
entrez:
3
11
2022
pubmed:
4
11
2022
medline:
4
11
2022
Statut:
epublish
Résumé
Uveitis is a T cell-mediated, intraocular inflammatory disease and one of the main causes of blindness in industrialized countries. There is a high unmet need for new immunomodulatory, steroid-sparing therapies, since only ciclosporin A and a single TNF-α-blocker are approved for non-infectious uveitis. A new small molecule inhibitor of dihydroorotate dehydrogenase (DHODH), an enzyme pivotal for [https://www.clinicaltrials.gov/ct2/show/NCT03634475], identifier [NCT03634475].
Identifiants
pubmed: 36325389
doi: 10.3389/fmed.2022.1023224
pmc: PMC9621317
doi:
Banques de données
ClinicalTrials.gov
['NCT03634475']
Types de publication
Journal Article
Langues
eng
Pagination
1023224Informations de copyright
Copyright © 2022 Thurau, Deuter, Heiligenhaus, Pleyer, Van Calster, Barisani-Asenbauer, Obermayr, Sperl, Seda-Zehetner and Wildner.
Déclaration de conflit d'intérêts
Authors FO, SS, and RS-Z were employed by Kiora Pharmaceuticals Inc. (previously Panoptes Pharma GmbH). The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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