Impact of Varicocele Repair on Semen Parameters in Infertile Men: A Systematic Review and Meta-Analysis.
Male infertility
Semen
Varicocele
Journal
The world journal of men's health
ISSN: 2287-4208
Titre abrégé: World J Mens Health
Pays: Korea (South)
ID NLM: 101596899
Informations de publication
Date de publication:
Apr 2023
Apr 2023
Historique:
received:
13
07
2022
accepted:
24
07
2022
pubmed:
4
11
2022
medline:
4
11
2022
entrez:
3
11
2022
Statut:
ppublish
Résumé
Despite the significant role of varicocele in the pathogenesis of male infertility, the impact of varicocele repair (VR) on conventional semen parameters remains controversial. Only a few systematic reviews and meta-analyses (SRMAs) have evaluated the impact of VR on sperm concentration, total motility, and progressive motility, mostly using a before-after analytic approach. No SRMA to date has evaluated the change in conventional semen parameters after VR compared to untreated controls. This study aimed to evaluate the effect of VR on conventional semen parameters in infertile patients with clinical varicocele compared to untreated controls. A literature search was performed using Scopus, PubMed, Embase, and Cochrane databases following the Population Intervention Comparison Outcome (PICOS) model (Population: infertile patients with clinical varicocele; Intervention: VR [any technique]; Comparison: infertile patients with clinical varicocele that were untreated; Outcome: sperm concentration, sperm total count, progressive sperm motility, total sperm motility, sperm morphology, and semen volume; Study type: randomized controlled trials and observational studies). A total of 1,632 abstracts were initially assessed for eligibility. Sixteen studies were finally included with a total of 2,420 infertile men with clinical varicocele (1,424 patients treated with VR This study provides a high level of evidence in favor of a positive effect of VR to improve conventional semen parameters in infertile men with clinical varicocele. To the best of our knowledge, this is the first SRMA to compare changes in conventional semen parameters after VR with changes in parameters of a control group over the same period. This is in contrast to other SRMAs which have compared semen parameters before and after VR, without reference to a control group. Our findings strengthen the available evidence and have a potential to upgrade professional societies' practice recommendations favoring VR to improve conventional semen parameters in infertile men.
Identifiants
pubmed: 36326166
pii: 40.e70
doi: 10.5534/wjmh.220142
pmc: PMC10042659
doi:
Types de publication
Journal Article
Langues
eng
Pagination
289-310Informations de copyright
Copyright © 2023 Korean Society for Sexual Medicine and Andrology.
Déclaration de conflit d'intérêts
The authors have nothing to disclose.
Références
Hum Reprod. 1991 Jul;6(6):811-6
pubmed: 1757519
Int Urol Nephrol. 2013 Apr;45(2):367-72
pubmed: 23392963
Int J Androl. 2007 Dec;30(6):531-6
pubmed: 17376219
BMJ. 2010 Mar 23;340:c332
pubmed: 20332509
Int J Androl. 1985 Dec;8(6):421-6
pubmed: 3835159
J Urol. 2020 Jan;203(1):48-56
pubmed: 31042452
Urology. 2018 Jul;117:70-77
pubmed: 29630953
Eur Urol. 2021 Nov;80(5):603-620
pubmed: 34511305
Fertil Steril. 1992 Jun;57(6):1289-93
pubmed: 1601152
Urology. 1996 Jan;47(1):73-6
pubmed: 8560666
Hum Reprod Update. 2001 Jan-Feb;7(1):70-7
pubmed: 11212078
Basic Clin Androl. 2020 Sep 10;30:15
pubmed: 32944248
Br J Urol. 1979 Dec;51(6):591-6
pubmed: 534846
Eur Urol. 1988;14(4):298-300
pubmed: 3169071
BMJ. 2003 Sep 6;327(7414):557-60
pubmed: 12958120
Asian J Androl. 2011 Nov;13(6):867-71
pubmed: 21785440
Hippokratia. 2007 Jul;11(3):99-104
pubmed: 19582201
Fertil Steril. 2014 Aug;102(2):469-75
pubmed: 24931206
Control Clin Trials. 1996 Feb;17(1):1-12
pubmed: 8721797
Niger J Clin Pract. 2020 Dec;23(12):1744-1747
pubmed: 33355829
BMJ. 2015 Jan 02;350:g7647
pubmed: 25555855
Eur Urol. 2011 Mar;59(3):455-61
pubmed: 21196073
Urol Int. 2008;80(2):172-6
pubmed: 18362488
J Endocrinol Invest. 2003 Nov;26(11):1059-64
pubmed: 15008241
Urology. 2007 Sep;70(3):532-8
pubmed: 17905111
Eur Urol. 2011 Oct;60(4):796-808
pubmed: 21733620
Fertil Steril. 2010 Apr;93(6):1907-10
pubmed: 19249033
Urology. 2015 Feb;85(2):357-62
pubmed: 25623687
Cochrane Database Syst Rev. 2021 Apr 23;4:CD000479
pubmed: 33890288
Int J Endocrinol. 2011;2011:916380
pubmed: 22190930
World J Mens Health. 2023 Jan;41(1):164-197
pubmed: 35791302
BMC Health Serv Res. 2014 Nov 21;14:579
pubmed: 25413154
Psychol Methods. 2006 Jun;11(2):193-206
pubmed: 16784338
Andrology. 2018 Jul;6(4):513-524
pubmed: 30134082
BMJ. 2019 Aug 28;366:l4898
pubmed: 31462531
Fertil Steril. 2007 Sep;88(3):639-48
pubmed: 17434508
World J Mens Health. 2022 Oct;40(4):636-652
pubmed: 35118839
JAMA. 2000 Apr 19;283(15):2008-12
pubmed: 10789670
Urol J. 2012 Spring;9(2):505-13
pubmed: 22641495
Eur Urol. 2016 Dec;70(6):1019-1029
pubmed: 27423503
J Assist Reprod Genet. 2018 Jun;35(6):1079-1082
pubmed: 29589295
Fertil Steril. 2021 Jan;115(1):54-61
pubmed: 33309062
Asian J Androl. 2015 Jan-Feb;17(1):74-80
pubmed: 25248652
J Urol. 2012 May;187(5):1540-7
pubmed: 22425089
Eur Radiol. 2020 Jan;30(1):11-25
pubmed: 31332561
J Clin Psychiatry. 2020 Sep 22;81(5):
pubmed: 32965803
Cochrane Database Syst Rev. 2012 Oct 17;10:CD000479
pubmed: 23076888
BJU Int. 2000 Feb;85(3):305-7
pubmed: 10671887
J Urol. 2021 Jan;205(1):44-51
pubmed: 33295258
Fertil Steril. 1993 Mar;59(3):613-6
pubmed: 8458466