Inherited human ITK deficiency impairs IFN-γ immunity and underlies tuberculosis.
Journal
The Journal of experimental medicine
ISSN: 1540-9538
Titre abrégé: J Exp Med
Pays: United States
ID NLM: 2985109R
Informations de publication
Date de publication:
02 01 2023
02 01 2023
Historique:
received:
17
03
2022
revised:
14
09
2022
accepted:
04
10
2022
entrez:
3
11
2022
pubmed:
4
11
2022
medline:
8
11
2022
Statut:
ppublish
Résumé
Inborn errors of IFN-γ immunity can underlie tuberculosis (TB). We report three patients from two kindreds without EBV viremia or disease but with severe TB and inherited complete ITK deficiency, a condition associated with severe EBV disease that renders immunological studies challenging. They have CD4+ αβ T lymphocytopenia with a concomitant expansion of CD4-CD8- double-negative (DN) αβ and Vδ2- γδ T lymphocytes, both displaying a unique CD38+CD45RA+T-bet+EOMES- phenotype. Itk-deficient mice recapitulated an expansion of the γδ T and DN αβ T lymphocyte populations in the thymus and spleen, respectively. Moreover, the patients' T lymphocytes secrete small amounts of IFN-γ in response to TCR crosslinking, mitogens, or forced synapse formation with autologous B lymphocytes. Finally, the patients' total lymphocytes secrete small amounts of IFN-γ, and CD4+, CD8+, DN αβ T, Vδ2+ γδ T, and MAIT cells display impaired IFN-γ production in response to BCG. Inherited ITK deficiency undermines the development and function of various IFN-γ-producing T cell subsets, thereby underlying TB.
Identifiants
pubmed: 36326697
pii: 213662
doi: 10.1084/jem.20220484
pmc: PMC9641312
pii:
doi:
Substances chimiques
Interferon-gamma
82115-62-6
Receptors, Antigen, T-Cell, alpha-beta
0
Receptors, Antigen, T-Cell, gamma-delta
0
emt protein-tyrosine kinase
EC 2.7.10.2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Intramural
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAID NIH HHS
ID : R01 AI095983
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001866
Pays : United States
Organisme : NCI NIH HHS
ID : F99 CA274708
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI162568
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI142737
Pays : United States
Organisme : NIDDK NIH HHS
ID : K08 DK128631
Pays : United States
Informations de copyright
© 2022 Ogishi et al.
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