Fetal Repair of Neural Tube Defects.

Pregnancy Child Female Humans Meningomyelocele / surgery Neural Tube Defects / surgery Fetus / surgery Fetal Therapies Prenatal Care Randomized Controlled Trials as Topic
MOMS trial Myelomeningocele Open neural tube defect Spina bifida

Journal

Clinics in perinatology
ISSN: 1557-9840
Titre abrégé: Clin Perinatol
Pays: United States
ID NLM: 7501306

Informations de publication

Date de publication:
12 2022
Historique:
entrez: 3 11 2022
pubmed: 4 11 2022
medline: 8 11 2022
Statut: ppublish

Résumé

Myelomeningocele is the most common congenital neurologic defect, and the only nonlethal disease addressed by fetal surgery. A randomized control trial has established amelioration of the Arnold-Chiari II malformation, reduced ventriculoperitoneal shunt rate, and improvement in distal neurologic function in patients that receive in utero repair. Long-term follow-up of these school-age children demonstrates the persistence of these effects. The use of stem cells in fetal repair is being investigated to further improve distal motor function.

Identifiants

DOI: 10.1016/j.clp.2022.06.004 PMID: 36328602
pubmed: 36328602
pii: S0095-5108(22)00061-6
doi: 10.1016/j.clp.2022.06.004
pii:
doi:

Types de publication

Journal Article Review Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

835-848

Informations de copyright

Copyright © 2022 Elsevier Inc. All rights reserved.

Auteurs

Su Yeon Lee (SY)

Department of Surgery, Division of Pediatric, Thoracic and Fetal Surgery, University of California Davis Medical Center, 2335 Stockton Boulevard, Room 5107, Sacramento, CA 95817, USA. Electronic address: suyle@ucdavis.edu.

Ramesha Papanna (R)

Department of Obstetrics, Gynecology and Reproductive Sciences, UT Health Science Center at Houston, 6410 Fannin Street, Suite 210, Houston, TX 77030, USA.

Diana Farmer (D)

Department of Surgery, University of California Davis Medical Center, 2335 Stockton Boulevard, Sacramento, CA 95817, USA.

KuoJen Tsao (K)

Department of Pediatric Surgery, UT Health Science Center at Houston, 6410 Fannin Street, Suite 950, Houston, TX 77030, USA.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Fetal Repair of Neural Tube Defects.
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Fetal Repair of Neural Tube Defects.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Fetal Repair of Neural Tube Defects.
questionsmedicales.fr › Malformations et maladies congénitales, héréditaires et néonatales › Malformations › Malformations du système nerveux › Anomalies du tube neural › Myéloméningocèle › Fetal Repair of Neural Tube Defects.
questionsmedicales.fr › Malformations et maladies congénitales, héréditaires et néonatales › Malformations › Malformations du système nerveux › Anomalies du tube neural › Fetal Repair of Neural Tube Defects.
questionsmedicales.fr › Structures de l'embryon › Foetus › Fetal Repair of Neural Tube Defects.
questionsmedicales.fr › Thérapeutique › Thérapies foetales › Fetal Repair of Neural Tube Defects.
questionsmedicales.fr › Établissements, main d'oeuvre et services de soins de santé › Services de santé › Soins aux patients › Prise en charge prénatale › Fetal Repair of Neural Tube Defects.
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études cliniques comme sujet › Essais cliniques comme sujet › Essais cliniques contrôlés comme sujet › Essais contrôlés randomisés comme sujet › Fetal Repair of Neural Tube Defects.