Host and immunosuppression-related factors influencing fibrosis occurrence post liver transplantation.
CYP3A5 genotype
TBX21
apoptosis
graft fibrosis
hepatocytes culture
liver tranpslant
mycophenolate mofetil
tacrolimus
Journal
Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923
Informations de publication
Date de publication:
2022
2022
Historique:
received:
12
09
2022
accepted:
27
09
2022
entrez:
4
11
2022
pubmed:
5
11
2022
medline:
5
11
2022
Statut:
epublish
Résumé
Post liver transplantation (LT) fibrosis has a negative impact on graft function. Cytokine production in the host immune response after LT may contribute to the variable CYP3A-dependent immunosuppressive drug disposition, with subsequent impact on liver fibrogenesis, together with host-related factors. We aimed to investigate whether the cytochrome P4503A5*3 (CYP3A5*3) or TBX21 genotypes impact post-LT liver fibrogenesis. Furthermore, the impact of immunosuppressants on cellular apoptosis has been evaluated using human hepatocytes harvested from cirrhotic explanted livers. We have enrolled 98 LT recipients that were followed for occurrence of liver fibrosis for at least 12 months. There was a statistically significant higher trough level of TAC in patients with homozygous CC-TBX21 genotype (7.83 ± 2.84 ng/ml) vs. 5.66 ± 2.16 ng/ml in patients without this genotype (
Identifiants
pubmed: 36330082
doi: 10.3389/fphar.2022.1042664
pii: 1042664
pmc: PMC9622773
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1042664Informations de copyright
Copyright © 2022 Iacob, Iacob, Manea, Uta, Chiosa, Dumbrava, Becheanu, Stoica, Popa, Brasoveanu, Hrehoret, Gheorghe, Gheorghe, Dima and Popescu.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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