Relationship between donated kidney volume determined by ultrasound adjusted for clinical factors and 1-month and 1-year creatinine clearance: A retrospective study.
Journal
Clinical nephrology
ISSN: 0301-0430
Titre abrégé: Clin Nephrol
Pays: Germany
ID NLM: 0364441
Informations de publication
Date de publication:
Jan 2023
Jan 2023
Historique:
accepted:
13
12
2022
pubmed:
5
11
2022
medline:
17
2
2023
entrez:
4
11
2022
Statut:
ppublish
Résumé
Graft volume as a surrogate of nephron numbers correlates with allograft function. The primary aim of this study was to correlate renal volume determined by ultrasound, adjusted to recipient clinical parameters in order to determine post-transplant renal function at the end of the first year. A total of 140 patients were enrolled in this study, including 75 males, with a total mean age of 41.2 ± 13.5 years. Clinical data of all donors and recipients undergoing kidney transplantation at our institution between 2003 and 2019 were reviewed. The volume of transplanted kidney was measured by ultrasonography on the fifth day after the operation and correlated with recipients' clinical parameters and then adjusted with first-month and first-year post-transplantation creatinine clearance. The mean allograft volume measured using ultrasonography was 175.0 ± 37.2 mL. Absolute donor kidney volume had a non-significant correlation with creatinine clearance at 1 month and at 1 year after transplantation. The kidney volume/recipient body weight ratio had a positive, and significant, correlation with creatinine clearance at 1 month and at 1 year after transplantation (r = 0.326, p < 0.001, and r = 0.183, p = 0.038, respectively). Our data demonstrated that 12-month creatinine clearance is influenced by ratio of donated kidney volume/recipient body weight.
Sections du résumé
BACKGROUND
BACKGROUND
Graft volume as a surrogate of nephron numbers correlates with allograft function. The primary aim of this study was to correlate renal volume determined by ultrasound, adjusted to recipient clinical parameters in order to determine post-transplant renal function at the end of the first year.
MATERIALS AND METHODS
METHODS
A total of 140 patients were enrolled in this study, including 75 males, with a total mean age of 41.2 ± 13.5 years. Clinical data of all donors and recipients undergoing kidney transplantation at our institution between 2003 and 2019 were reviewed. The volume of transplanted kidney was measured by ultrasonography on the fifth day after the operation and correlated with recipients' clinical parameters and then adjusted with first-month and first-year post-transplantation creatinine clearance.
RESULTS
RESULTS
The mean allograft volume measured using ultrasonography was 175.0 ± 37.2 mL. Absolute donor kidney volume had a non-significant correlation with creatinine clearance at 1 month and at 1 year after transplantation. The kidney volume/recipient body weight ratio had a positive, and significant, correlation with creatinine clearance at 1 month and at 1 year after transplantation (r = 0.326, p < 0.001, and r = 0.183, p = 0.038, respectively).
CONCLUSION
CONCLUSIONS
Our data demonstrated that 12-month creatinine clearance is influenced by ratio of donated kidney volume/recipient body weight.
Identifiants
pubmed: 36331020
pii: 189824
doi: 10.5414/CN110964
doi:
Substances chimiques
Creatinine
AYI8EX34EU
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM