Insights into the evolution of enzymatic specificity and catalysis: From Asgard archaea to human adenylate kinases.


Journal

Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440

Informations de publication

Date de publication:
04 Nov 2022
Historique:
entrez: 4 11 2022
pubmed: 5 11 2022
medline: 9 11 2022
Statut: ppublish

Résumé

Enzymatic catalysis is critically dependent on selectivity, active site architecture, and dynamics. To contribute insights into the interplay of these properties, we established an approach with NMR, crystallography, and MD simulations focused on the ubiquitous phosphotransferase adenylate kinase (AK) isolated from

Identifiants

pubmed: 36332013
doi: 10.1126/sciadv.abm4089
pmc: PMC9635829
doi:

Substances chimiques

Adenylate Kinase EC 2.7.4.3

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

eabm4089

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Auteurs

Apoorv Verma (A)

Department of Chemistry, Umeå University, 901 87 Umeå, Sweden.

Emma Åberg-Zingmark (E)

Department of Chemistry, Umeå University, 901 87 Umeå, Sweden.

Tobias Sparrman (T)

Department of Chemistry, Umeå University, 901 87 Umeå, Sweden.

Ameeq Ul Mushtaq (AU)

Department of Chemistry, Umeå University, 901 87 Umeå, Sweden.

Per Rogne (P)

Department of Chemistry, Umeå University, 901 87 Umeå, Sweden.

Christin Grundström (C)

Department of Chemistry, Umeå University, 901 87 Umeå, Sweden.

Ronnie Berntsson (R)

Department of Medical Biochemistry and Biophysics, Umeå University, 901 87 Umeå, Sweden.
Wallenberg Centre for Molecular Medicine, Umeå University, 901 87 Umeå, Sweden.

Uwe H Sauer (UH)

Department of Chemistry, Umeå University, 901 87 Umeå, Sweden.

Lars Backman (L)

Department of Chemistry, Umeå University, 901 87 Umeå, Sweden.

Kwangho Nam (K)

Department of Chemistry and Biochemistry, University of Texas at Arlington, Arlington, TX 76019, USA.

Elisabeth Sauer-Eriksson (E)

Department of Chemistry, Umeå University, 901 87 Umeå, Sweden.

Magnus Wolf-Watz (M)

Department of Chemistry, Umeå University, 901 87 Umeå, Sweden.

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Classifications MeSH