Multi-ancestry genome-wide association analyses identify novel genetic mechanisms in rheumatoid arthritis.

Humans Genome-Wide Association Study Genetic Predisposition to Disease Polymorphism, Single Nucleotide / genetics Asian People / genetics Arthritis, Rheumatoid / genetics Adaptor Proteins, Signal Transducing / genetics

Journal

Nature genetics
ISSN: 1546-1718
Titre abrégé: Nat Genet
Pays: United States
ID NLM: 9216904

Informations de publication

Date de publication:
11 2022
Historique:
received: 01 12 2021
accepted: 26 09 2022
pubmed: 6 11 2022
medline: 15 11 2022
entrez: 5 11 2022
Statut: ppublish

Résumé

Rheumatoid arthritis (RA) is a highly heritable complex disease with unknown etiology. Multi-ancestry genetic research of RA promises to improve power to detect genetic signals, fine-mapping resolution and performances of polygenic risk scores (PRS). Here, we present a large-scale genome-wide association study (GWAS) of RA, which includes 276,020 samples from five ancestral groups. We conducted a multi-ancestry meta-analysis and identified 124 loci (P < 5 × 10

Identifiants

DOI: 10.1038/s41588-022-01213-w PMID: 36333501 PMC: PMC10165422
pubmed: 36333501
doi: 10.1038/s41588-022-01213-w
pii: 10.1038/s41588-022-01213-w
pmc: PMC10165422
mid: NIHMS1887719
doi:

Substances chimiques

TNIP2 protein, human 0
Adaptor Proteins, Signal Transducing 0

Types de publication

Meta-Analysis Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1640-1651

Subventions

Organisme : NIAMS NIH HHS
ID : R01 AR049880
Pays : United States
Organisme : NIAMS NIH HHS
ID : T32 AR069516
Pays : United States
Organisme : Department of Health
ID : NIHR300826
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : U01 CA176726
Pays : United States
Organisme : NIAMS NIH HHS
ID : UC2 AR081023
Pays : United States
Organisme : NHGRI NIH HHS
ID : T32 HG002295
Pays : United States
Organisme : Versus Arthritis
ID : 21229
Pays : United Kingdom
Organisme : NIAMS NIH HHS
ID : R01 AR063759
Pays : United States
Organisme : Versus Arthritis
ID : 19739
Pays : United Kingdom
Organisme : NHGRI NIH HHS
ID : U01 HG012009
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR003096
Pays : United States
Organisme : NCI NIH HHS
ID : UM1 CA186107
Pays : United States
Organisme : NIAMS NIH HHS
ID : UH2 AR067677
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG009379
Pays : United States
Organisme : Wellcome Trust
ID : 207491/Z/17/Z
Pays : United Kingdom

Informations de copyright

© 2022. The Author(s), under exclusive licence to Springer Nature America, Inc.

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Auteurs

Kazuyoshi Ishigaki (K)

Center for Data Sciences, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Laboratory for Human Immunogenetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
ORCID: 0000-0003-2881-0657

Saori Sakaue (S)

Center for Data Sciences, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.
Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
ORCID: 0000-0003-3618-9717

Chikashi Terao (C)

Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Clinical Research Center, Shizuoka General Hospital, Shizuoka, Japan.
The Department of Applied Genetics, The School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan.
ORCID: 0000-0002-6452-4095

Yang Luo (Y)

Center for Data Sciences, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0001-7385-6166

Kyuto Sonehara (K)

Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.
Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Suita, Japan.

Kensuke Yamaguchi (K)

Department of Genomic Function and Diversity, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.
Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
ORCID: 0000-0001-8288-1240

Tiffany Amariuta (T)

Center for Data Sciences, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Halıcıoğlu Data Science Institute, University of California San Diego, La Jolla, CA, USA.
Department of Medicine, University of California San Diego, La Jolla, CA, USA.
ORCID: 0000-0003-0121-1726

Chun Lai Too (CL)

Immunogenetics Unit, Allergy and Immunology Research Center, Institute for Medical Research, National Institutes of Health Complex, Ministry of Health, Kuala Lumpur, Malaysia.
Department of Medicine, Division of Rheumatology, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.

Vincent A Laufer (VA)

Department of Clinical Immunology and Rheumatology, University of Alabama at Birmingham School of Medicine, Birmingham, AL, USA.
Department of Pathology, Michigan Medicine, Ann Arbor, MI, USA.

Ian C Scott (IC)

Haywood Academic Rheumatology Centre, Haywood Hospital, Midlands Partnership NHS Foundation Trust, Burslem, UK.
Primary Care Centre Versus Arthritis, School of Medicine, Keele University, Keele, UK.
ORCID: 0000-0002-1268-9808

Sebastien Viatte (S)

Centre for Genetics and Genomics Versus Arthritis, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.
NIHR Manchester Biomedical Research Centre, Manchester University Foundation Trust, Manchester, UK.
ORCID: 0000-0001-6471-3358

Meiko Takahashi (M)

Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
ORCID: 0000-0002-8344-5472

Koichiro Ohmura (K)

Department of Rheumatology and Clinical immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Akira Murasawa (A)

Department of Rheumatology, Niigata Rheumatic Center, Niigata, Japan.

Motomu Hashimoto (M)

Department of Advanced Medicine for Rheumatic Diseases, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Department of Clinical Immunology, Graduate School of Medicine, Osaka City University, Osaka, Japan.

Hiromu Ito (H)

Department of Advanced Medicine for Rheumatic Diseases, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Department of Orthopaedic Surgery, Kurashiki Central Hospital, Kurashiki, Japan.
ORCID: 0000-0002-1827-382X

Mohammed Hammoudeh (M)

Rheumatology Division, Department of Internal Medicine, Hamad Medical Corporation, Doha, Qatar.

Samar Al Emadi (SA)

Rheumatology Division, Department of Internal Medicine, Hamad Medical Corporation, Doha, Qatar.

Basel K Masri (BK)

Department of Internal Medicine, Jordan Hospital, Amman, Jordan.

Hussein Halabi (H)

Section of Rheumatology, Department of Internal Medicine, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia.
ORCID: 0000-0002-5174-8292

Humeira Badsha (H)

Dr. Humeira Badsha Medical Center, Emirates Hospital, Dubai, United Arab Emirates.

Imad W Uthman (IW)

Department of Rheumatology, American University of Beirut, Beirut, Lebanon.

Xin Wu (X)

Department of Rheumatology and Immunology, Shanghai Changzeng Hospital, The Second Military Medical University, Shanghai, China.

Li Lin (L)

Department of Rheumatology and Immunology, Shanghai Changzeng Hospital, The Second Military Medical University, Shanghai, China.

Ting Li (T)

Department of Rheumatology and Immunology, Shanghai Changzeng Hospital, The Second Military Medical University, Shanghai, China.

Darren Plant (D)

Centre for Genetics and Genomics Versus Arthritis, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
ORCID: 0000-0003-1395-9344

Anne Barton (A)

Centre for Genetics and Genomics Versus Arthritis, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
NIHR Manchester Biomedical Research Centre, Manchester University Foundation Trust, Manchester, UK.
ORCID: 0000-0003-3316-2527

Gisela Orozco (G)

Centre for Genetics and Genomics Versus Arthritis, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
NIHR Manchester Biomedical Research Centre, Manchester University Foundation Trust, Manchester, UK.
ORCID: 0000-0002-3479-0448

Suzanne M M Verstappen (SMM)

NIHR Manchester Biomedical Research Centre, Manchester University Foundation Trust, Manchester, UK.
Centre for Epidemiology Versus Arthritis, Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, The University of Manchester, Manchester, UK.

John Bowes (J)

Centre for Genetics and Genomics Versus Arthritis, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
NIHR Manchester Biomedical Research Centre, Manchester University Foundation Trust, Manchester, UK.
ORCID: 0000-0003-4659-031X

Alexander J MacGregor (AJ)

Norwich Medical School, University of East Anglia, Norwich, UK.

Suguru Honda (S)

Institute of Rheumatology, Tokyo Women's Medical University Hospital, Tokyo, Japan.
Department of Rheumatology, Tokyo Women's Medical University School of Medicine, Tokyo, Japan.

Masaru Koido (M)

Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
ORCID: 0000-0002-0348-0666

Kohei Tomizuka (K)

Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.

Yoichiro Kamatani (Y)

Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Laboratory of Complex Trait Genomics, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.
ORCID: 0000-0001-8748-5597

Hiroaki Tanaka (H)

The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health Japan, Kitakyushu, Japan.

Eiichi Tanaka (E)

Institute of Rheumatology, Tokyo Women's Medical University Hospital, Tokyo, Japan.
Department of Rheumatology, Tokyo Women's Medical University School of Medicine, Tokyo, Japan.
ORCID: 0000-0003-2850-326X

Akari Suzuki (A)

Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.

Yuichi Maeda (Y)

Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Suita, Japan.
Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Japan.
Department of Immunopathology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita, Japan.

Kenichi Yamamoto (K)

Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.
Laboratory of Statistical Immunology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita, Japan.
Department of Pediatrics, Osaka University Graduate School of Medicine, Suita, Japan.
ORCID: 0000-0001-9594-7050

Satoru Miyawaki (S)

Department of Neurosurgery, Faculty of Medicine, the University of Tokyo, Tokyo, Japan.

Gang Xie (G)

Lunenfeld-Tanenbaum Research Institute, Toronto, Ontario, Canada.

Jinyi Zhang (J)

Lunenfeld-Tanenbaum Research Institute, Toronto, Ontario, Canada.
Department of Medicine, University of Toronto, Toronto, Ontario, Canada.

Christopher I Amos (CI)

Baylor College of Medicine, Houston, TX, USA.
ORCID: 0000-0002-8540-7023

Edward Keystone (E)

The University of Toronto, Toronto, Ontario, Canada.

Gertjan Wolbink (G)

Department of Rheumatology, Amsterdam Rheumatology and Immunology Center (ARC), Reade, Amsterdam, the Netherlands.

Irene van der Horst-Bruinsma (I)

Department of Rheumatology & Clinical Immunology/ARC, Amsterdam Institute for Infection and Immunity, Amsterdam UMC location Vrije Universiteit, Amsterdam, the Netherlands.

Jing Cui (J)

Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

Katherine P Liao (KP)

Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
Massachusetts Veterans Epidemiology Research and Information Center, VA Boston Healthcare System, Boston, MA, USA.
ORCID: 0000-0002-4797-3200

Robert J Carroll (RJ)

Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN, USA.

Hye-Soon Lee (HS)

Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea.
Hanyang University Institute for Rheumatology Research, Seoul, Korea.

So-Young Bang (SY)

Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea.
Hanyang University Institute for Rheumatology Research, Seoul, Korea.

Katherine A Siminovitch (KA)

Lunenfeld-Tanenbaum Research Institute, Toronto, Ontario, Canada.
Departments of Medicine and Immunology, University of Toronto, Toronto, Ontario, Canada.

Niek de Vries (N)

Department of Rheumatology & Clinical Immunology/ARC, Amsterdam Institute for Infection and Immunity, Amsterdam UMC location AMC/University of Amsterdam, Amsterdam, the Netherlands.
ORCID: 0000-0002-6257-8604

Lars Alfredsson (L)

Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
ORCID: 0000-0003-1688-6697

Solbritt Rantapää-Dahlqvist (S)

Department of Public Health and Clinical Medicine, Rheumatology, Umeå University, Umeå, Sweden.
ORCID: 0000-0001-8259-3863

Elizabeth W Karlson (EW)

Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

Sang-Cheol Bae (SC)

Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea.
Hanyang University Institute for Rheumatology Research, Seoul, Korea.
ORCID: 0000-0003-4658-1093

Robert P Kimberly (RP)

Center for Clinical and Translational Science, Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.

Jeffrey C Edberg (JC)

Center for Clinical and Translational Science, Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.

Xavier Mariette (X)

Department of Rheumatology, Université Paris-Saclay, Assistance Pubique - Hôpitaux de Paris, Hôpital Bicêtre, INSERM UMR1184, Le Kremlin Bicêtre, France.
ORCID: 0000-0002-4244-5417

Tom Huizinga (T)

Leiden University Medical Center, Leiden, the Netherlands.
ORCID: 0000-0001-7033-7520

Philippe Dieudé (P)

University of Paris Cité, Inserm, PHERE, F-75018, Paris, France.
Department of Rheumatology, Hôpital Bichat, APHP, Paris, France.
ORCID: 0000-0002-4814-0307

Matthias Schneider (M)

Department of Rheumatology & Hiller Research Unit Rheumatology, UKD, Heinrich-Heine University, Düsseldorf, Germany.

Martin Kerick (M)

Institute of Parasitology and Biomedicine Lopez-Neyra, CSIC, Granada, Spain.
ORCID: 0000-0002-6298-4514

Joshua C Denny (JC)

Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN, USA.
All of Us Research Program, Office of the Director, National Institutes of Health, Bethesda, MD, USA.
Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA.

Koichi Matsuda (K)

Laboratory of Genome Technology, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Laboratory of Clinical Genome Sequencing, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.
ORCID: 0000-0001-7292-2686

Keitaro Matsuo (K)

Division of Cancer Epidemiology and Prevention, Department of Preventive Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan.
Department of Cancer Epidemiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
ORCID: 0000-0003-1761-6314

Tsuneyo Mimori (T)

Department of Rheumatology and Clinical immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Fumihiko Matsuda (F)

Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Keishi Fujio (K)

Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Yoshiya Tanaka (Y)

The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health Japan, Kitakyushu, Japan.
ORCID: 0000-0002-0807-7139

Atsushi Kumanogoh (A)

Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Suita, Japan.
Centre for Genetics and Genomics Versus Arthritis, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Japan.
Department of Immunopathology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita, Japan.
ORCID: 0000-0003-4749-7117

Matthew Traylor (M)

Department of Medical & Molecular Genetics, King's College London, London, UK.
Department of Genetics, Novo Nordisk Research Centre Oxford, Oxford, UK.
Clinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, UK.

Cathryn M Lewis (CM)

Department of Medical & Molecular Genetics, King's College London, London, UK.
Social, Genetic and Developmental Psychiatry Centre, King's College London, London, UK.
ORCID: 0000-0002-8249-8476

Stephen Eyre (S)

Centre for Genetics and Genomics Versus Arthritis, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
NIHR Manchester Biomedical Research Centre, Manchester University Foundation Trust, Manchester, UK.
ORCID: 0000-0002-1251-6974

Huji Xu (H)

Department of Rheumatology and Immunology, Shanghai Changzeng Hospital, The Second Military Medical University, Shanghai, China.
School of Clinical Medicine Tsinghua University, Beijing, China.
Peking-Tsinghua Center for Life Sciences, Tsinghua University, Beijing, China.

Richa Saxena (R)

Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
ORCID: 0000-0003-2233-1065

Thurayya Arayssi (T)

Department of Internal Medicine, Weill Cornell Medicine-Qatar, Education City, Doha, Qatar.

Yuta Kochi (Y)

Department of Genomic Function and Diversity, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.
Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
ORCID: 0000-0002-8012-5078

Katsunori Ikari (K)

Institute of Rheumatology, Tokyo Women's Medical University Hospital, Tokyo, Japan.
Department of Orthopedic Surgery, Tokyo Women's Medical University School of Medicine, Tokyo, Japan.
Division of Multidisciplinary Management of Rheumatic Diseases, Tokyo Women's Medical University, Tokyo, Japan.
ORCID: 0000-0001-9066-2005

Masayoshi Harigai (M)

Institute of Rheumatology, Tokyo Women's Medical University Hospital, Tokyo, Japan.
Division of Rheumatology, Department of Internal Medicine, Tokyo Women's Medical University School of Medicine, Tokyo, Japan.
ORCID: 0000-0002-6418-2603

Peter K Gregersen (PK)

Robert S. Boas Center for Genomics and Human Genetics, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA.

Kazuhiko Yamamoto (K)

Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.

S Louis Bridges (S)

Department of Medicine, Hospital for Special Surgery, New York, NY, USA.
Division of Rheumatology, Weill Cornell Medicine, New York, NY, USA.

Leonid Padyukov (L)

Department of Medicine, Division of Rheumatology, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.
ORCID: 0000-0003-2950-5670

Javier Martin (J)

Institute of Parasitology and Biomedicine Lopez-Neyra, CSIC, Granada, Spain.
ORCID: 0000-0002-2202-0622

Lars Klareskog (L)

Department of Medicine, Division of Rheumatology, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.
ORCID: 0000-0001-9601-6186

Yukinori Okada (Y)

Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan. yokada@sg.med.osaka-u.ac.jp.
Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Suita, Japan. yokada@sg.med.osaka-u.ac.jp.
Laboratory of Statistical Immunology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita, Japan. yokada@sg.med.osaka-u.ac.jp.
Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan. yokada@sg.med.osaka-u.ac.jp.
Center for Infectious Disease Education and Research (CiDER), Osaka University, Suita, Japan. yokada@sg.med.osaka-u.ac.jp.
Department of Genome Informatics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. yokada@sg.med.osaka-u.ac.jp.
ORCID: 0000-0002-0311-8472

Soumya Raychaudhuri (S)

Center for Data Sciences, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. soumya@broadinstitute.org.
Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. soumya@broadinstitute.org.
Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA. soumya@broadinstitute.org.
Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. soumya@broadinstitute.org.
Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA. soumya@broadinstitute.org.
Centre for Genetics and Genomics Versus Arthritis, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK. soumya@broadinstitute.org.
ORCID: 0000-0002-1901-8265

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Multi-ancestry genome-wide association...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › Multi-ancestry genome-wide association...
questionsmedicales.fr › Phénomènes génétiques › Génotype › Prédisposition génétique à une maladie › Multi-ancestry genome-wide association...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Polymorphisme de nucléotide simple › Multi-ancestry genome-wide association...
questionsmedicales.fr › Personnes › Asiatiques › Multi-ancestry genome-wide association...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Polyarthrite rhumatoïde › Multi-ancestry genome-wide association...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines adaptatrices de la transduction du signal › Multi-ancestry genome-wide association...