Mosquito host-seeking diel rhythm and chemosensory gene expression is affected by age and Plasmodium stages.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
05 11 2022
05 11 2022
Historique:
received:
01
06
2022
accepted:
01
11
2022
entrez:
6
11
2022
pubmed:
6
11
2022
medline:
9
11
2022
Statut:
epublish
Résumé
Malaria parasites can affect vector-related behaviours, increasing transmission success. Using Anopheles gambiae and Plasmodium falciparum, we consider the effect of interaction between infection stage and vector age on diel locomotion in response to human odour and the expression of antennal chemosensory genes. We identified age-dependent behavioural diel compartmentalisation by uninfected females post-blood meal. Infection disrupts overall and diel activity patterns compared with age-matched controls. In this study, mosquitoes carrying transmissible sporozoites were more active, shifting activity periods which corresponded with human host availability, in response to human odour. Older, uninfected, blood-fed females displayed reduced activity during their peak host-seeking period in response to human odour. Age- and infection stage-specific changes in odour-mediated locomotion coincide with altered transcript abundance of select chemosensory genes suggesting a possible molecular mechanism regulating the behaviour. We hypothesize that vector-related behaviours of female mosquitoes are altered by infection stage and further modulated by the age post-blood meal of the vector. Findings may have important implications for malaria transmission and disease dynamics.
Identifiants
pubmed: 36335172
doi: 10.1038/s41598-022-23529-7
pii: 10.1038/s41598-022-23529-7
pmc: PMC9637142
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
18814Subventions
Organisme : Vetenskapsrådet
ID : VR/2017-01229
Organisme : Vetenskapsrådet
ID : VR/2014-3331
Organisme : Jeanssons Stiftelser
ID : SJ-2018
Informations de copyright
© 2022. Crown.
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